Vascular-specific growth factors and blood vessel formation

Yancopouloš, George D.; Davis, Samuel; Gale, Nicholas W.; Rudge, John S.; Wiegand, Stanley J.; Holash, Jocelyn

doi:10.1038/35025215

Cited by 3,357 publications

(2,695 citation statements)

References 60 publications

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“…However, transplantation of islets in these aFGF microcapsules in the omental pouch did not result in better transplantation outcomes, c‐peptide levels, and glycemic control was less beneficial than in controls not containing aFGF 36. Their data and ours suggest that establishment of a stable vascular network is complex and might require several angiogenic factors to promote vessel sprouting and remodeling of the vascular network 38. This is supported by clinical studies demonstrating even detrimental effects after injections of a single growth factor 39, 40, 41…”

Section: Discussionmentioning

confidence: 57%

See 1 more Smart Citation

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet‐transplantation enhances immediate post‐transplant islet graft function but not long‐term normoglycemia

Smink

Swart

et al. 2017

J Biomedical Materials Res

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The liver as transplantation site for pancreatic islets is associated with significant loss of islets, which can be prevented by grafting in a prevascularized, subcutaneous scaffold. Supporting vascularization of a scaffold to limit the period of ischemia is challenging and was developed here by applying liposomes for controlled release of angiogenic factors. The angiogenic capacity of platelet‐derived growth factor, vascular endothelial growth factor, acidic fibroblast growth factor (aFGF), and basic FGF were compared in a tube formation assay. Furthermore, the release kinetics of different liposome compositions were tested. aFGF and L‐α‐phosphatidylcholine/cholesterol liposomes were selected to support vascularization. Two dosages of aFGF‐liposomes (0.5 and 1.0 μg aFGF per injection) were administered weekly for a month after which islets were transplanted. We observed enhanced efficacy in the immediate post‐transplant period compared to the untreated scaffolds. However, on the long‐term, glucose levels of the aFGF treated animals started to increase to diabetic levels. These results suggest that injections with aFGF liposomes do improve vascularization and the immediate restoration of blood glucose levels but does not facilitate the long‐term survival of islets. Our data emphasize the need for long‐term studies to evaluate potential beneficial and adverse effects of vascularization protocols of scaffolds. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2533–2542, 2017.

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Section: Discussionmentioning

confidence: 57%

“…Angiopoietin‐1 and ephrin‐B2 are important for further maturation and remodeling of migrating endothelial cells into vessels. Angiopoietin‐1 also maintains quiescence and stability after maturation of the vessels 38, 50. We believe that both pathways are important for a stable vascular network within our scaffold.…”

Section: Discussionmentioning

confidence: 92%

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet‐transplantation enhances immediate post‐transplant islet graft function but not long‐term normoglycemia

Smink

Swart

et al. 2017

J Biomedical Materials Res

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“…In the adult, the process of angiogenesis is predominantly mediated by VEGF stimulation from the initiation of vascular permeability, followed by endothelial cell proliferation and migration. 45 Finally, formation of new vascular network through proper maturation and remodeling. 45 In adults, angiogenesis is normally quiescent, unless, stimulated by appropriate angiogenic factors, this process can occur during embryogenesis, 45 menstruation, 45 and wound healing.…”

Section: The Role Of Epo In the Eyementioning

confidence: 99%

Revisiting the role of erythropoietin for treatment of ocular disorders

Ding

Leow

Munisvaradass

et al. 2016

Eye

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Erythropoietin (EPO) is a glycoprotein hormone conventionally thought to be responsible only in producing red blood cells in our body. However, with the discovery of the presence of EPO and EPO receptors in the retinal layers, the EPO seems to have physiological roles in the eye. In this review, we revisit the role of EPO in the eye. We look into the biological role of EPO in the development of the eye and the physiologic roles that it has. Apart from that, we seek to understand the mechanisms and pathways of EPO that contributes to the therapeutic and pathological conditions of the various ocular disorders such as diabetic retinopathy, retinopathy of prematurity, glaucoma, age-related macular degeneration, optic neuritis, and retinal detachment. With these understandings, we discuss the clinical applications of EPO for treatment of ocular disorders, modes of administration, EPO formulations, current clinical trials, and its future directions.

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“…Endothelial cells express cell-type-specific tyrosine kinase receptors, including vascular endothelial growth factor, Tie, and Eph receptors [41,42], while alveolar epithelial cells also express specific molecules [43]. A549 cells are type 2 alveolar cells and synthesize surfactant proteins [44].…”

Section: Discussionmentioning

confidence: 99%

Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis

et al. 2018

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Streptococcus pneumoniae is a major pathogen that causes pneumonia, sepsis, and meningitis. The candidate combox site 4 (ccs4) gene has been reported to be a pneumococcal competence-induced gene. Such genes are involved in development of S. pneumoniae competence and virulence, though the functions of ccs4 remain unknown. In the present study, the role of Ccs4 in the pathogenesis of pneumococcal meningitis was examined. We initially constructed a ccs4 deletion mutant and complement strains, then examined their association with and invasion into human brain microvascular endothelial cells. Wild-type and Ccs4-complemented strains exhibited significantly higher rates of association and invasion as compared to the ccs4 mutant strain. Deletion of ccs4 did not change bacterial growth activity or expression of NanA and CbpA, known brain endothelial pneumococcal adhesins. Next, mice were infected either intravenously or intranasally with pneumococcal strains. In the intranasal infection model, survival rates were comparable between wild-type strain-infected and ccs4 mutant strain-infected mice, while the ccs4 mutant strain exhibited a lower level of virulence in the intravenous infection model. In addition, at 24 hours after intravenous infection, the bacterial burden in blood was comparable between the wild-type and ccs4 mutant strain-infected mice, whereas the wild-type strain-infected mice showed a significantly higher bacterial burden in the brain. These results suggest that Ccs4 contributes to pneumococcal invasion of host brain tissues and functions as a virulence factor.

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Vascular-specific growth factors and blood vessel formation

Cited by 3,357 publications

References 60 publications

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet‐transplantation enhances immediate post‐transplant islet graft function but not long‐term normoglycemia

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet‐transplantation enhances immediate post‐transplant islet graft function but not long‐term normoglycemia

Revisiting the role of erythropoietin for treatment of ocular disorders

Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis

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