Vascular Smooth Muscle Cells Derived from Atherosclerotic Human Arteries Exhibit Greater Adhesion, Migration, and Proliferation Than Venous Cells

The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls

“…Insulin is a highly potent cell growth factor, which can promote vascular smooth muscle cell proliferation, thus playing an important role in the development of atherosclerosis 28 . Since RBP4 is related to IR, it has been suggested to be involved in the occurrence and development of atherosclerosis and CVD 11 .…”

Ginsenoside Rg1 inhibits proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-α1

“…Thus inhibition of VSMC hyperpro-liferation is one of the key pharmacological strategies for prevention of atherosclerosis. TNF-α, a cytokine that is secreted by VSMC in the atherosclerotic neointima, can promote cell growth and movement, both of which are critical for the initiation and progression of vascular lesions [6] . An investigation of ginsenoside Rg1-induced alterations in protein expression in TNF-α-activated VSMC will aid in understanding the molecular mechanism of ginsenoside Rg1.…”

Alisol A 24-Acetate, a Triterpenoid Derived from <b><i>Alisma orientale</i></b>, Inhibits Ox-LDL-Induced Phenotypic Transformation and Migration of Rat Vascular Smooth Muscle Cells through Suppressing ERK1/2 Signaling

“…Following vascular damage caused by inflammation and oxidative stress, however, VSMCs migrate from the media to the intima and re-enter the cell cycle [4], which is characterized by G1- to S-phase cell cycle transition and transformation from a contractile to a synthetic phenotype [5]. Synthetic VSMCs are found to synthesize and secrete a large number of cytokines, ECM and matrix metalloproteinases (MMPs) [6]. Such a transformation has a great impact on VSMC adhesion and migration, and leads to vascular wall remodeling.…”