Vascular risk factors in Alzheimer's disease — Preliminary report

Stefanova, Elka; Pavlovic, Aleksandra; Jovanović, Ž.; Veselinović, N.; Despotovic, Ida; Stojković, Tanja; Šternić, Nadežda; Kostić, Vladimir

doi:10.1016/j.jns.2012.07.065

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…A logistic regression model was established, and the results indicated that each unit increase in the sRAGE level was associated with a 54% reduction in disease risk (OR 0.46[95% CI 0.22–0.96], p = 0.04), whereas each unit increase in the serum AGE-P level was associated with a 72% increase in MCI risk (OR 1.72[95% CI 1.31–2.28], p< 0.01) after adjusting for additional risk factors such as the presence of carotid plaques, coronary heart disease or diabetic nephropathy [ 31 – 33 ], which showed significance differences between the two groups and exerted an impact on cognition in type 2 diabetes mellitus patients.…”

Section: Resultsmentioning

confidence: 99%

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

Wang

Huang

et al. 2016

PLoS ONE

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ObjectiveReceptor for advanced glycation end products (AGEs; RAGE) binds to both AGEs and amyloid-beta peptides. RAGE is involved in chronic complications of type 2 diabetes and Alzheimer’s disease. We aimed to investigate the roles of RAGE, AGEs and the Gly82Ser polymorphism of RAGE in mild cognitive impairment (MCI) among type 2 diabetes patients.MethodsOf the 167 hospitalized type 2 diabetes patients recruited, 82 satisfied the diagnostic criteria for MCI, and 85 matched control individuals were classified as non-MCI. Demographic data were collected, and the soluble RAGE (sRAGE) concentrations, serum AGE-peptide (AGE-P) levels, RAGE Gly82Ser genotype and neuropsychological test results were examined.ResultsThe MCI group exhibited a decreased sRAGE level (0.87±0.35 vs. 1.05±0.52 ng/ml, p<0.01) and an increased serum AGE-P level (3.54±1.27 vs. 2.71±1.18 U/ml, p<0.01) compared with the control group. Logistic regression analysis indicated that each unit reduction in the sRAGE concentration increased the MCI risk by 54% (OR 0.46[95% CI 0.22–0.96], p = 0.04) and that each unit increase in the AGE-P level increased the MCI risk by 72% in the type 2 diabetes patients (OR 1.72[95% CI 1.31–2.28], p<0.01). The serum sRAGE level was negatively correlated with the score on the trail making test-B (TMT-B) (r = -0.344, p = 0.002), which indicates early cognitive deficits related to diabetes. Moreover, the AGE-P level was positively correlated with multiple cognitive domains (all p<0.05). No significant differences in the neuropsychological test results or serum RAGE concentrations between the different RAGE genotypes or in the RAGE genotype frequencies between the MCI and control groups were identified (all p>0.05).ConclusionsThe RAGE pathway partially mediates AGE-induced MCI in diabetic patients. The serum AGE-P level may serve as a serum biomarker of MCI in these individuals, and sRAGE represents a predictor and even a potential intervention target of early cognitive decline in type 2 diabetes patients.Trial registrationAdvanced Glycation End Products Induced Cognitive Impairment in Diabetes: BDNF Signal Meditated Hippocampal Neurogenesis ChiCTR-OCC-15006060

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Section: Resultsmentioning

confidence: 99%

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

Wang

Huang

et al. 2016

PLoS ONE

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“…In previous studies, it was shown that AD was associated with vascular risk factors and cardiovascular disease process 5,20–23. Hypertension, diabetes, stroke, and atherosclerosis have been shown to increase AD risk 7,24,25.…”

Section: Discussionmentioning

confidence: 98%

Altered diastolic function and aortic stiffness in Alzheimer’s disease

Çalık¹,

Özcan²,

Yüksel³

et al. 2014

CIA

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Background: Alzheimer's disease (AD) is closely linked to cardiovascular risk factors. Methods: Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with normal cognitive function. Results: The peak mitral flow velocity of the early rapid filling wave (E) was lower, and the peak velocity of the late filling wave caused by atrial contraction (A), deceleration time of peak E velocity, and isovolumetric relaxation time were higher in the AD group. The early myocardial peak (E a ) velocity was significantly lower in AD patients, whereas the late diastolic (A a ) velocity and E/E a ratio were similar between the two groups. In Alzheimer patients, stiffness index and pressure-strain elastic modulus were higher, and distensibility was significantly lower in the AD group compared to the control. Interatrial electromechanical delay was significantly longer in the AD group. Conclusion: Our findings suggest that patients with AD are more likely to have diastolic dysfunction, higher atrial conduction times, and increased arterial stiffness compared to the controls of same sex and similar age.

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“…The frequency of white matter lesions in women with AD varies [ 32 , 36 ]. Although the etiology of AD is still not completely elucidated, it is now known that the presence of cerebral white matter lesions, vascular risk factors and endothelial dysfunction contribute to its development [ 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

Abheiden

Doornik

Aukes

et al. 2015

Dement Geriatr Cogn Disord Extra

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Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD). Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD. Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed. Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD. Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.

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Vascular risk factors in Alzheimer's disease — Preliminary report

Cited by 21 publications

References 39 publications

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

Altered diastolic function and aortic stiffness in Alzheimer’s disease

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

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Vascular risk factors in Alzheimer's disease — Preliminary report

Cited by 21 publications

References 39 publications

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

Altered diastolic function and aortic stiffness in Alzheimer&rsquo;s disease

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

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Altered diastolic function and aortic stiffness in Alzheimer’s disease