Vascular retinal findings after COVID-19 vaccination in 11 cases: a coincidence or consequence?

Silva, Letícia S. C. da; Finamor, Luciana Peixoto; Andrade, Gabriel Costa Ferreira; Lima, Luiz H.; Zett, Cláudio; Muccioli, Cristina; Sarraff, Eduardo Pantaleão; Marinho, Paula; Peruchi, Julia; Oliveira, Raíza Dantas de Lira; Giralt, Lena; Charcan, Ivonne; Fonollosa, Alex; Diaz, Jose Daniel; Davis, Janet L.; Nascimento, Heloísa; Belfort, Rubens

doi:10.5935/0004-2749.20220071

Cited by 26 publications

(22 citation statements)

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“…Landa et al presented one middle-aged male developing into suspected SS 10 days after smallpox vaccination [ 9 ]. Recently, Silva et al reported several vascular retinal disorders after COVID-19 vaccines, which included two cases with a highly possible diagnosis of SS 14–15 days after CoronaVac (Sinovac) [ 10 ]. In our present case, the SS was diagnosed based on clinical symptoms and imaging evidence, which showed highly suspicious SS that may have been induced by the ChAdOx1 vaccine (AstraZeneca).…”

Section: Discussionmentioning

confidence: 99%

Susac Syndrome Following COVID-19 Vaccination: A Case Report

et al. 2022

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Due to the COVID-19 pandemic, numerous vaccines have been developed for the disease. However, with large-scale vaccination has come the gradual emergence of immunological phenomena caused by these new vaccines. Herein, we report a 48-year-old female with a sudden onset of inferior visual field defects in the left eye following her first dose of the ChAdOx1 vaccine. Dilated fundus examination combined with optical coherence tomography and fluorescein angiography confirmed the diagnosis of branch retinal artery occlusion. Within 4 weeks following vaccination, symptoms associated with hearing impairment developed, and magnetic resonance imaging revealed leptomeningeal enhancement. The diagnosis of Susac syndrome (SS) was confirmed. The development of SS may be caused by endotheliopathy resulting from the molecular mimicry of the ChAdOx1 vaccine. Clinicians should be aware of the symptoms of SS, which may develop after COVID-19 vaccination. Further experimental surveillance and case–control studies are required to confirm this relationship.

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Section: Discussionmentioning

confidence: 99%

Susac Syndrome Following COVID-19 Vaccination: A Case Report

et al. 2022

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“…Four patients experienced branch retinal artery occlusion 22.8 days on the average after the last vaccine dose application 9 . In a study of 11 patients with visual complaints after SARS-CoV-2 vaccinations, 5 had retinal artery occlusion and four had retinal vein occlusion 10 . Retinal arteriovenous occlusion was reported one day after the first dose of the AZV in a 77yo male 11 .…”

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confidence: 99%

Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations

Finsterer¹

2022

Journal of Stroke and Cerebrovascular Diseases

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“…However, it cannot be ruled out that late-onset side effects may also occur after vaccination. While several case series suggested a causal mechanism between RVOD and COVID-19 vaccination [ 3 , 4 , 20 , 21 , 22 ], the mechanisms behind it are not understood and highly speculative. Our data, however, failed to indicate any relationship between COVID-19 vaccination and RVOD incidence.…”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

Feltgen¹,

Ach

Ziemssen

et al. 2022

JCM

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Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June–31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case–control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted. Results: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case–control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60–1.45, p = 0.75) in connection with a vaccination within a 4-week window. Conclusions: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.

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Vascular retinal findings after COVID-19 vaccination in 11 cases: a coincidence or consequence?

Cited by 26 publications

References 0 publications

Susac Syndrome Following COVID-19 Vaccination: A Case Report

Susac Syndrome Following COVID-19 Vaccination: A Case Report

Retinal artery/vein occlusion complicating SARS-CoV-2 vaccinations

Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

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