Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

McLay, Kaitlin M.; Fontana, Federico Y.; Nederveen, Joshua P.; Guida, Federico F.; Paterson, Donald H.; Pogliaghi, Silvia; Murias, Juan M.

doi:10.1113/ep085406

Cited by 93 publications

(154 citation statements)

References 37 publications

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Section: Testing Procedures and Instrumentationmentioning

confidence: 99%

“…NIRS measurements have been shown to be valid and highly reproducible. 22,23,25 were averaged per testing period (ie, baseline, occlusion, exercise, and recovery) and analyzed using 2-way ANOVA with repeated measures, followed by Tukey post hoc (Statistica 7.0; StatSoft). A regression line (y=a+bx; b=slope and a=intercept) was applied to the occlusion/reperfusion data.…”

Section: Testing Procedures and Instrumentationmentioning

confidence: 99%

“…Using the arterial occlusion/reoxygenation maneuver, the NIRS technology provides information on skeletal muscle's oxidative capacity, microvascular function, and muscle oxygenation at rest and during exercise. [22][23][24][25] Our aims were to examine in vivo skeletal muscle oxygenation and microvascular function (as assessed by muscle microvascular reactivity), at rest and during submaximal handgrip exercise, and their associations with (1) arterial stiffness and other macrovascular function indices and (2) BP responses during handgrip exercise, in newly diagnosed, never-treated patients with hypertension (HYP) and age-, sex-, and BMI-matched normotensive individuals (NORMO). We hypothesized that (1) untreated individuals with hypertension will present compromised muscle oxygenation and impaired microvascular function versus normotensives and (2) these alterations could limit oxygen delivery to exercising muscles in hypertensive patients versus normotensives and contribute to further amplifications in BP responses during exercise in the former group.…”

mentioning

confidence: 99%

“…25,32 The TSI reperfusion slope and magnitude were used as indices of the vessels' ability to accommodate the blood flow increase (microvascular reactivity). 22,23 The peak hyperemic response was calculated as the difference between peak TSI during reperfusion and baseline TSI.24,31 During exercise, peak and average TSI responses were used as indices of muscle oxygen extraction. 33 The BP response during the first minute of exercise (ΔBP=BP exercise −BP baseline ) was divided by the average TSI response during exercise and was used as an index of exercise BP rise per unit of muscle oxygenation (ie, ΔBP/ΔTSI).…”

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confidence: 99%

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Impaired Muscle Oxygenation and Elevated Exercise Blood Pressure in Hypertensive Patients

et al. 2017

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E ssential hypertension is characterized by sustained elevations of blood pressure (BP) that can lead to target organ damage and an increased risk for cardiovascular disease. 1Potential life-threatening outcomes of hypertension, such as stroke, renal insufficiency, and cardiac hypertrophy, had been initially perceived as a result of macrovascular alterations. These macrovascular events, however, do not occur independently of microvascular derangement. [2][3][4] Studies have shown that alterations in microvascular structure (rarefaction), vasomotor tonus (enhanced vasoconstriction or blunted vasodilation), and endothelial dysfunction are principal processes in the pathogenesis of hypertension and are evident in several organs/tissue types. [5][6][7][8] In the skeletal muscle, microvascularization is important for oxygen and nutrient supply and for effective metabolite clearance. Studies in hypertension have shown structural or functional impairments in the microvasculature within skeletal muscles, 8 implying a reduced capacity for oxygen delivery and exchange. Furthermore, animal studies using experimental models of hypertension suggested that mitochondrial dysfunction (ie, decreased expression of mitochondrial components and defects in respiratory complexes) and increased oxidative stress result in impaired oxidative capacity and reduced mitochondrial ATP production.9,10 Importantly, in these animals, the mitochondrial dysfunction and the reduced oxidative capacity were present before the development of hypertension, suggesting a possible role of these processes to the pathogenesis of hypertension.11 However, information on skeletal muscle microvascular alterations and oxidative Abstract-This study examined in vivo (1) skeletal muscle oxygenation and microvascular function, at rest and during handgrip exercise, and (2) their association with macrovascular function and exercise blood pressure (BP), in newly diagnosed, never-treated patients with hypertension and normotensive individuals. Ninety-one individuals (51 hypertensives and 40 normotensives) underwent office and 24-hour ambulatory BP, arterial stiffness, and central aortic BP assessment, followed by a 5-minute arterial occlusion and a 3-minute submaximal handgrip exercise. Changes in muscle oxygenated and deoxygenated hemoglobin and tissue oxygen saturation were continuously monitored by nearinfrared spectroscopy and beat-by-beat BP by Finapres. Hypertensives had higher (P<0.001) central aortic BP and pulse wave velocity versus normotensives and exhibited (1) a blunted tissue oxygen saturation response during occlusion, with slower (P=0.006) deoxygenation rate, suggesting reduced muscle oxidative capacity, and (2) a slower reoxygenation rate and blunted hyperemic response (P<0.05), showing reduced microvascular reactivity. Muscle oxygenation responses were correlated with aortic systolic and pulse pressure and augmentation index (P<0.05; age and body mass index (BMI) adjusted). When exercising at the same submaximal intensity, hypertensives required a sig...

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Section: Testing Procedures and Instrumentationmentioning

confidence: 99%

Section: Testing Procedures and Instrumentationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Impaired Muscle Oxygenation and Elevated Exercise Blood Pressure in Hypertensive Patients

et al. 2017

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“…In this study oxygenation kinetics is discussed with respect to the time to half recovery (T½ recovery) of the tissue saturation index (TSI). TSI is determined by O2Hb/(O2Hb+HHb) and is presented as a percentage and as such it is considered to be a reflection of muscle perfusion, oxygen delivery and oxygen consumption 8 . Assessments of TSI have been used to separate ability groups in rock climbing during sustained 4 and intermittent 2 contractions as well as during recovery post exhaustive handgrip exercise 9 .…”

Section: Methodsmentioning

confidence: 99%

Differences in Oxygenation Kinetics Between the Dominant and Nondominant Flexor Digitorum Profundus in Rock Climbers

Giles¹,

Garrido²,

De-la-O³

et al. 2017

International Journal of Sports Physiology and Performance

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Purpose:To examine differences in oxygenation kinetics in the nondominant and dominant flexor digitorum profundus (FDP) of rock climbers.Methods:Participants were 28 sport climbers with a range of on-site abilities (6a+ to 8a French Sport). Using near-infrared spectroscopy, oxygenation kinetics of the FDP was assessed by calculating the time to half recovery (t1/2 recovery) of the tissue-saturation index (TSI) after 3–5 min of ischemia.Results:A 2-way mixed-model ANOVA found a nonsignificant interaction (P = .112) for TSI by sex. However, there was a significant main effect (P = .027) of handedness (dominant vs nondominant FDP). The dominant forearm recovered 13.6% faster (t1/2 recovery mean difference = 1.12 s, 95% CI 0.13–2.10 s) than the nondominant FDP. This was not affected by 6-mo on-site climbing ability or sex (P = .839, P = .683).Conclusions:Significant intraindividual differences in oxygenation kinetics of the FDP were found. Improvements in oxygenation kinetics in the FDP are likely due to the abilities of the muscle to deliver, perfuse, and consume oxygen. These enhancements may be due to structural adaptations in the microvasculature, such as an increase in capillary density and enhanced improvement in capillary filtration.

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Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors

et al. 2016

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Aims/hypothesis Gestational diabetes mellitus (GDM) is a risk factor for the development of endothelial dysfunction and cardiovascular disease. However, in vivo microvascular endothelial function in GDM has not been investigated. This study aimed to examine, using near-infrared spectroscopy (NIRS), whether: (1) there are differences in microvascular reactivity and skeletal muscle oxygen consumption (mVat rest and during exercise between GDM and uncomplicated pregnancies; and (2) ) and blunted hyperaemia (ΔTSI 6.8 ± 2.9 vs 9.5 ± 3.4) compared with controls (p < 0.01). Despite similar handgrip strength in the GDM and control groups (29.1 ± 8.1 vs 26.2 ± 10.4 kg, respectively), during repeated forearm contractions, women with GDM presented a blunted TSI response (6.5 ± 3.9 vs 19.2 ± 10.9; p < 0.01) and a reduced capacity to maintain the predetermined handgrip (23.4 ± 2.9 vs 27.4 ± 3.8%, p < 0.05). NIRS indices correlated with PWV, 24 h BP and blood glucose concentration earlier in pregnancy (r = 0.40-0.60; p < 0.05). Conclusions/interpretation Women with GDM exhibited a characteristic blunted TSI curve, showing alterations in muscle oxygenation and microvascular responsiveness compared with women with uncomplicated pregnancies. These alterations were manifested during exercise and possibly contribute to the reduced exercise tolerance in GDM. NIRS indices correlated with macrovascular indices (arterial stiffness) and 24 h BP.

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Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation

Cited by 93 publications

References 37 publications

Impaired Muscle Oxygenation and Elevated Exercise Blood Pressure in Hypertensive Patients

Impaired Muscle Oxygenation and Elevated Exercise Blood Pressure in Hypertensive Patients

Differences in Oxygenation Kinetics Between the Dominant and Nondominant Flexor Digitorum Profundus in Rock Climbers

Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors

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