Vascular Response Occurring at 3 Months After Everolimus-Eluting Cobalt–Chromium Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction vs. Stable Coronary Artery Disease

Abstract

occurs within 3 months after DES implantation in AMI patients and that delayed vessel healing at the thrombotic lesion is observed within 30 days after DES implantation. 1,3-6 Thus, rapid progression of vascular healing during the early phase, together with thromboresistance, is the desired outcome of DES for AMI patients.Cobalt-chromium everolimus-eluting stent (CoCr-EES), Stent thrombosis (ST) rarely occurs in patients undergoing 2nd-generation drug-eluting stent (DES) implantation for coronary artery disease (CAD), although it remains a critical complication. 1 Patients with acute myocardial infarction (AMI) especially have a relatively high incidence of ST as compared with stable CAD patients. 2 It has also been demonstrated that ST mainly

Comparison of MECHANISM of early and late vascular responses following treatment of ST-elevation acute myocardial infarction with two different everolimus-eluting stents: a randomized controlled trial of biodegradable versus durable polymer stents

“…Moreover, the incidence of late and very late stent thrombosis has been remarkably reduced by newer-generation DES, with > 70% of stent thrombosis events occurring in the early post-procedural phase. In addition, we previously reported that arterial healing after DP-EES and BP-sirolimus-eluting stent implantation was significantly delayed, especially in the early phase in STEMI patients than in those with stable coronary artery disease [12,13]. These findings increase the clinical importance of investigating early-phase vascular healing after stenting, particularly in the STEMI setting [1,14].…”

A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of acute myocardial infarction and stable coronary artery disease patients: results of the MECHANISM-ULTIMASTER study

“…The final uncovered rate was excellent, approaching zero at 12 months. We previously conducted the MECHANISM-AMI study using CoCr-EES [ 9 ]. Although not uniformly comparable, the uncovered strut rate after 3 months of BP-SES implantation was approximately 10%, higher than that of CoCr-EES at 5.5%.…”

“…OFDI analysis was performed by two independent core laboratories (ULTIMASTER AMI: Kobe Cardiovascular Core Laboratory (KCCL), Kobe University Graduate School of Medicine, Kobe, Japan, MECHANISM-ULTIMASTER Elective: ICAL, Iwate Medical University, Yahaba, Japan) using OFDI software (Terumo, Japan) and according to the standard operating procedure of the MECHANISM-ULTIMASTER study and published methods (Fig. 2) [7][8][9]. Inter-and intra-observer reproducibility were demonstrated in supplemental file.…”