Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone

Souza, Marco Aurélio Martins de; Souza, Bruno Martins de; Geber, Selmo

doi:10.1097/gme.0b013e3182290b26

Cited by 4 publications

(2 citation statements)

References 28 publications

(26 reference statements)

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“…Ultrasonography of the ophthalmic artery is a well‐established imaging modality and has been utilized for studying a variety of non‐obstetric pathologies, including glaucoma, heart failure, systemic atherosclerosis and multiple sclerosis. In the gynecological context, it has been demonstrated that use of tibolone by healthy postmenopausal women does not alter the Doppler indices of this vessel. Ophthalmic Doppler sonography is well tolerated by patients and does not take long to perform.…”

Section: Introductionmentioning

confidence: 99%

Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of women with pre‐eclampsia

Kane

Brennecke

Costa

2016

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of women with pre‐eclampsia

Kane

Brennecke

Costa

2016

Ultrasound in Obstet & Gyne

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“…18 In an RCT with placebo in a group of 100 healthy postmenopausal women younger than 65 years, tibolone did not affect the resistance of small-caliber cerebral arteries. 27 Finally, in other cohort studies or in RCTs in which the objective was not the consideration of cardiovascular events, no more myocardial infarction or stroke was observed with tibolone, perhaps because the age of the women studied was closer to the age at natural menopause. 28 …”

Section: Cardiovascular Effectsmentioning

confidence: 97%

Spanish Menopause Society position statement

et al. 2013

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Tibolone is a drug with complex tissue-specific action that exhibits a combination of estrogenic, progestogenic, and slight androgenic activity. Its variable profile explains its clinical effects, depending on the target tissue where it is metabolized, its metabolites' affinity for and potency in hormone receptors, and probable enzymatic activity modulation.In recent reviews and clinical trials, the effectiveness of tibolone in alleviating different hot flush menopause symptoms, mainly in mood and sexuality disorders, has been noted. In Spain, tibolone is the most prescribed hormonal treatment, and one of the most common complaints among postmenopausal women is change in sexual drive. For such reason, a panel of experts from the Spanish Menopause Society met to develop usage recommendations based on the best evidence available.

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Can uterine artery Doppler parameters predict copper intrauterine device-induced side effects?

Mutlu

Demir

Mutlu

2013

The European Journal of Contraception & Reproductive Health

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OBJECTIVES To evaluate the predictive value of uterine artery Doppler characteristics in predicting copper intrauterine device (IUD)-induced side effects such as dysmenorrhoea and menorrhagia, and worsening of dyspareunia. METHODS One hundred and twenty regularly menstruating women were enrolled in the study. All underwent transvaginal uterine artery Doppler analysis in the early follicular phase, on two occasions: before insertion of the IUD, and six months after insertion. Pre- and post-insertion resistance (RI) and pulsatility (PI) indices of the uterine arteries were measured. Doppler parameters were compared between subjects experiencing an increase in IUD-mediated side effects and those reporting no change. RESULTs RI and PI of all participants before and after IUD insertion were not significantly different (0.75 ± 0.06 vs. 0.74 ± 0.09, p = 0.49; 1.81 ± 0.55 vs. 1.83 ± 0.70, p = 0.7, respectively). No significant difference was found in the comparison of pre- and post-insertion PI and RI values of women who had increased- and those who experienced no change in dysmenorrhoea, dyspareunia and duration/amount of menstruation. CONCLUSIONS No major changes in uterine blood flow were observed in women experiencing increased menstrual bleeding, dyspareunia or dysmenorrhoea after insertion of a copper IUD. The occurrence of these effects cannot be predicted by prior Doppler flow analysis.

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Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone

Abstract: Our study demonstrates that tibolone administration to healthy postmenopausal women does not affect the resistance of small-caliber cerebral arteries.

Cited by 4 publications

References 28 publications

Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of women with pre‐eclampsia

Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of women with pre‐eclampsia

Spanish Menopause Society position statement

Can uterine artery Doppler parameters predict copper intrauterine device-induced side effects?

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