Vascular Reactivity During Migraine Attacks: A Transcranial Doppler Study

Zwetsloot, CP; Caekebeke, J.F.V.; Odink, J.; Ferrari, Michael

doi:10.1111/j.1526-4610.1991.hed3109593.x

Cited by 21 publications

(23 citation statements)

References 5 publications

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“…It is known that ischemic cerebral infarction preferentially affects the posterior cerebral artery distribution in migraine patients (5). Zwetsloot et al (17) did not find any difference in vasomotor reactivity in MCA and the basilar artery in MwoA compared to healthy subjects. Hyperreactivity, hyporeactivity, and no difference in reactivity were observed.…”

Section: Discussionmentioning

confidence: 83%

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Perko¹,

Oblak²,

Šabovič

et al. 2011

Acta Neurologica Scandinavica

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OBJECTIVE - Cerebral infarction preferentially affects the posterior cerebral artery distribution in migraine patients. The results obtained from the few known studies that have compared the anterior and posterior cerebral endothelial function are contradictory. To the best of our knowledge, cerebrovascular reactivity to L-arginine (CVR), measured by transcranial Doppler sonography (TCD), has not been previously used to determine the posterior cerebral endothelial function in migraine patients with (MwA) and without aura (MwoA). MATERIALS AND METHODS - Forty migraine patients without comorbidities (20 MwA, 20 MwoA) and 20 healthy subjects were included. By employing strict inclusion criteria, we avoided the possible vascular risk factors. Mean arterial velocity in the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) was measured by TCD before and after infusion of L-arginine, and CVR to L-arginine was then calculated. RESULTS - All migraine patients had lower CVR to L-arginine in PCA (P = 0.002) and similar in MCA (P = 0.29) compared to healthy subjects. This difference was also present in MwA and MwoA compared to healthy subjects (P = 0.003). CONCLUSIONS - Lower CVR to L-arginine in PCA in migraine patients could associate migraine and cerebral infarcts that are more common in the posterior cerebral artery distribution.

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Section: Discussionmentioning

confidence: 83%

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Perko¹,

Oblak²,

Šabovič

et al. 2011

Acta Neurologica Scandinavica

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“…Compared to headache-free persons, interictal migraineurs showed increased cerebral vasoreactivity to CO 2 stimuli in some studies (17)(18)(19)(20)(21), but not in others (8,22,23). In response to cardiovascular autonomic tests such as head-up tilt, cold pressure or Valsalva manoeuver, the results were again conflicting (24,25).…”

Section: Discussionmentioning

confidence: 99%

Cerebrovascular Response to Repetitive Visual Stimulation in Interictal Migraine with Aura

Nedeltchev

Arnold²,

Schwerzmann

et al. 2004

Cephalalgia

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Cortical hypersensitivity and absent habituation to different stimuli have been observed in migraine patients. These features might also be transmitted to the cerebral vasoreactivity, but results are conflicting so far. Transcranial Doppler ultrasound (TCD) was used to assess cerebral blood flow velocity (CBFV) changes in the middle (MCA) and posterior cerebral arteries (PCA) in relation to repetitive checkerboard visual stimulation. Stimulation consisted of 10 consecutive cycles, each comprising 10 s stimulation and 10 s rest. TCD recordings were analysed using stimulus-related averaging algorithm. Data of 19 interictal migraineurs with aura were compared to those of 19 headache-free healthy volunteers. The CBFV increase in PCA and in MCA during visual stimulation was significantly larger and steeper in migraineurs than in controls (P = 0.017 and P = 0.005). The response in PCA remained stable over the 10 stimulation cycles, both in migraineurs and in controls. The response in MCA was stable only in migraineurs. In controls it decreased over the last 5 stimulation cycles compared with the first 5 cycles (P = 0.04). Migraineurs with aura exhibit a larger cerebrovascular response to repetitive visual stimulation compared to headache-free subjects. A reduced adaptation to environmental stimuli in migraine is suggested, since there was no habituation in migraineurs in contrast to healthy controls.

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“…In two relatively large studies with 31 [20] and 51 [21] patients, respectively, no decrease in blood flow velocity was found with TCD during migraine attacks. Furthermore, a recent magnetic resonance angiography (MRA) study found no MCA or extracranial part of the middle meningeal artery (MMA) dilatation during nitroglycerin-induced migraine ( n = 20) [22].…”

Section: Results and Commentsmentioning

confidence: 99%

Verisimilitude (or “truthlikeness”) as an alternative to pro and cons: migraine and cluster headache mechanisms

Tfelt‐Hansen

2010

J Headache Pain

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Calculating verisimilitude (or “truthlikeness”) ad modum Popper is a quantitative alternative to the usual pros and cons in migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine; CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine; rCBF in migraine without aura; NO and pathophysiology of migraine; neurogenic inflammation and migraine; aura in cluster headache; and hypothalamic activation in cluster headache. It is concluded that verisimilitude calculations can be helpful when judging pathophysiological problems in migraine and cluster headache.

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Vascular Reactivity During Migraine Attacks: A Transcranial Doppler Study

Cited by 21 publications

References 5 publications

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients

Cerebrovascular Response to Repetitive Visual Stimulation in Interictal Migraine with Aura

Verisimilitude (or “truthlikeness”) as an alternative to pro and cons: migraine and cluster headache mechanisms

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