Vascular prosthetic Graft Infection: Epidemiology, Bacteriology, Pathogenesis and Treatment

Chiesa, Roberto; Astore, D.; Frigerio, Silla; Garriboli, Luca; Piccolo, Gaetano; Castellano, Renata; Scalamogna, M.; Odero, Attilio; Pirrelli, Stefano; Biasi, G; Mingazzini, P; Biglioli, Paolo; Polvani, Gianluca; Guarino, Anna; Agrifoglio, G; Tori, Antonio; Spina, G. P.

doi:10.1080/00015458.2002.11679305

Cited by 129 publications

(105 citation statements)

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“…Erken dönem enfeksiyonlarda en sık karşılaşılan etkenler Pseudomonas, Proteus, E. coli ve Salmonella'dır. 13 Yaptığımız mikrobiolojik analizde ise en sık izole ettiğimiz bakteri E.coli oldu. Bu durum bizde greftin kontaminasyonu, postoperatif yetersiz yara bakımı, abdominal kavite komplikasyonları konularında soru işaretleri oluşmasını sağladı.…”

Section: Discussionunclassified

Treatment Procedures in Vascular Prosthetic Graft Infections

Ünal¹,

Şen²,

Erkanlı³

et al. 2015

Turkiye Klinikleri J Cardiovasc Sci

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Section: Discussionunclassified

Treatment Procedures in Vascular Prosthetic Graft Infections

Ünal¹,

Şen²,

Erkanlı³

et al. 2015

Turkiye Klinikleri J Cardiovasc Sci

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“…In cases of AGI, antibiotics play a very important role. At the beginning of AGI diagnosis, broad-spectrum antibiotics are used while culture-specifi c antibiotics are used in the later period of treatment (82). The duration of antimicrobial treatment in patients with AGI after the removal of infected graft is controversial.…”

Section: Treatment Optionsmentioning

confidence: 99%

Management of aortic graft infections – the present strategy and future perspectives

Treska¹,

Certík²,

Moláček³

2016

BLL

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Aortic graft infections (AGI) are serious complications of open and endovascular types of surgery with an incidence rate of 0.6-3 %. AGI are associated with 30-60 % perioperative mortality and 40-60 % morbidity rate with limb amputation rates between 10 % and 40 %. The economic cost of AGI is substantial. At the time of aortic reconstruction, almost 90 % of patients have one or more predisposing factors for AGI. The diagnosis is based on clinical symptomatology, laboratory markers, microbial cultures, and imaging modalities. The general principle of surgical treatment lies in the removal of infected graft, debridement of infected periprosthetic tissues, and vascular reconstruction by in situ or extra-anatomic bypass with long-term antibiotic therapy. The conservative treatment is used only for selected patients with endograft infection. This review summarizes the current knowledge about the incidence, predisposing factors, etiology, diagnosis, treatment options, and prevention of aortic vascular graft and endograft infections. With the growing number of endovascular procedures we can expect more cases of infected aortic endografts in patients with severe comorbidities in the near future, where the recent radical surgical approach (graft excision, debridement, and new revascularization) cannot be used. Therefore the less invasive, sophisticated and individualized treatment strategies will have to be used in search of the best therapeutic approach to each specifi c patient (Fig. 4, Ref. 82). Text in PDF www.elis.sk.

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“…However, this approach bears the risk of early graft failure due to infection (Chiesa et al, 2002;Zetrenne et al, 2007;Herscu and Wilson, 2009) or thrombotic occlusion (Kraiss and Johansen, 1995;Bonhomme et al, 2010). A major prerequisite for the prevention of these serious complications is a rapid and adequate vascularisation of the vascular prostheses during the early healing process.…”

Section: Prosthetic Vascular Graftsmentioning

confidence: 99%

The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue

Laschke

Vollmar²,

Menger³

2011

eCM

144

128

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The implantation of biomaterials into the human body has become an indispensable part of almost all fi elds of modern medicine. Accordingly, there is an increasing need for appropriate approaches, which can be used to evaluate the suitability of different biomaterials for distinct clinical indications. The dorsal skinfold chamber is a sophisticated experimental model, which has been proven to be extremely valuable for the systematic in vivo analysis of the dynamic interaction of small biomaterial implants with the surrounding host tissue in rats, hamsters and mice. By means of intravital fl uorescence microscopy, this chronic model allows for repeated analyses of various cellular, molecular and microvascular mechanisms, which are involved in the early infl ammatory and angiogenic host tissue response to biomaterials during the initial 2-3 weeks after implantation. Therefore, the dorsal skinfold chamber has been broadly used during the last two decades to assess the in vivo performance of prosthetic vascular grafts, metallic implants, surgical meshes, bone substitutes, scaffolds for tissue engineering, as well as for locally or systemically applied drug delivery systems. These studies have contributed to identify basic material properties determining the biocompatibility of the implants and vascular ingrowth into their surface or internal structures. Thus, the dorsal skinfold chamber model does not only provide deep insights into the complex interactions of biomaterials with the surrounding soft tissues of the host but also represents an important tool for the future development of novel biomaterials aiming at an optimisation of their biofunctionality in clinical practice.

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Vascular prosthetic Graft Infection: Epidemiology, Bacteriology, Pathogenesis and Treatment

Abstract: No significant difference in terms of clinical outcome was observed when using fresh, rather than cryopreserved homografts. The only factor that significantly influenced the survival rate appeared to be the aorto-enteric fistula.

Cited by 129 publications

References 0 publications

Treatment Procedures in Vascular Prosthetic Graft Infections

Treatment Procedures in Vascular Prosthetic Graft Infections

Management of aortic graft infections – the present strategy and future perspectives

The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue

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