Vascular Permeability in Experimental Brain Tumors

Rl, Wright

doi:10.1177/000331976701800201

Cited by 9 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microvascular abnormalities with fenestration and discontinuation of endothelium apparently responsible for the breakdown of the BBB have been described in viral induced glioma in a number of mammalian species (11), in human primary brain tumors (18), and in metastatic brain tumors (19). Numerous investigators (20,21,22,23,24) have shown that large solid tumors metastatic to the brain contain abnormal microvasculature quite permeable to blood-born solutes, including compounds not usually thought to cross the BBB.…”

Section: Discussionmentioning

confidence: 99%

Management of brain metastases from breast cancer by combination chemotherapy

et al. 1983

View full text Add to dashboard Cite

Since most patients with brain metastases from breast cancer have disseminated disease elsewhere and a dismal prognosis when treated by whole brain irradiation alone, we investigated the use of systemic chemotherapy in 66 such patients. Fifty-two percent (34 of 66 patients) demonstrated an objective response to this therapy which was similar to the results obtained in patients treated for extracranial metastases. Eighteen patients who subsequently had recurrence of brain metastases were successfully retreated with secondary chemotherapy. The median duration of remission in 34 responders was ten months. The median survival, from the time of chemotherapy for brain metastases, was 13.1 months in 34 responders (range 5-74+) vs. 3.0 months in 32 non-responders (P less than 0.001). These findings suggest that systemic chemotherapy is effective in the treatment of patients with brain metastases from breast cancer by inducing remission and prolonging survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Management of brain metastases from breast cancer by combination chemotherapy

et al. 1983

View full text Add to dashboard Cite

show abstract

“…Recent, more reliable data point toward relatively poor nutritional supply of tumors. The pattern of vascular development in an induced ependymoblastoma of C3H mice has been described by Wright (1963Wright ( , 1967. The findings of these and other anatomical studies suggest that factors exist which would severely limit the supply of nutrients to neoplastic cells, even if there were no change in blood flow to a neoplasm during growth.…”

Section: Discussionmentioning

confidence: 80%

“…The findings of these and other anatomical studies suggest that factors exist which would severely limit the supply of nutrients to neoplastic cells, even if there were no change in blood flow to a neoplasm during growth. Among these are the failure of vessels to penetrate deeply (Goldacre & Sylven, 1959, the formation of sinusoids and other aberrant vessels resulting in a relative decline in vascular surface available for exchange (Wright, 1967). and the development of arteriovenous shunting vessels bypassing large areas of the tumor capillary network (Wright, 1963;Kliegerman & Henel, 1961).…”

Section: Discussionmentioning

confidence: 99%

“…This includes the decreases of blood flow and oxygen saturation seen in some tumors after drugs have increased blood flow to surrounding tissues (Kruuv et al, 1967), flow reversals under observation (Kliegerman & Henel, 1961 ) , and higher than normal oxygen levels in the venous blood draining some tumors (Bierman et al, 1952). Vascular damage during growth is also indicated by the increased permeability of tumor vessels (Wright, 1967;Tator & Olszewski, 1966).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Circulatory Factors in the Carbohydrate Metabolism of an Experimental Glial Neoplasm*

Maker

Lehrer

Silides

et al. 1969

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

“…The tumors simulated various histological features seen in human brain tumors and are generally considered good models for human neuro-oncology (Crafts and Wilson 1977;Rubinstein 1977;Wright 1967;Zimmerman 1969;Zimmerman and Arnold 1941).The tumors developed from 125 to 400 days following the surgical implantation of small crystalline carcinogenic pellets (about 1mm diameter ϫ 1.5mm in length) into the adult mouse brain. An inflammatory reactive gliosis, involving macrophages and virus-like particles in reactive cells, was associated with pellets that formed tumors (Zimmerman 1969).…”

Section: Experimental Brain Tumor Models In Adult Micementioning

confidence: 99%

Perspectives on Brain Tumor Formation Involving Macrophages, Glia, and Neural Stem

Seyfried¹

2001

pbm

View full text Add to dashboard Cite

The incidence of brain tumors is rising in children and the elderly, but little is known about the mechanisms underlying brain tumor initiation and progression. In the 1940s, Zimmerman and coworkers exploited the tumor-promoting potential of polycyclic hydrocarbons to produce brain tumor models in adult mice that simulated the neuropathology of human brain tumors. Based on these early findings and on recent neurobiological studies of stem cells, I propose that crystalline carcinogenic pellets surgically implanted in the central nervous system establish over time a microenvironment that fosters proliferation and genetic damage in neural stem cells and their progenitors. Moreover, activated glia (microglia and astrocytes) and recruited macrophages mediate these processes. Gradually local tissue fields, which normally restrict stem cell proliferation, become disorganized, leading to further stem cell proliferation, genetic damage, and eventual neoplasia. Depending on age, location, and the state of glial/macrophage activation, the resulting brain tumor may resemble transformed neural progenitors aborted in more or less differentiated states. This hypothesis integrates the general mechanisms by which neural stem cells, glia, and macrophages orchestrate the initiation and progression of brain cancer. Also discussed are implications of these concepts for the diagnosis and therapy of human brain tumors.

show abstract

Vascular Permeability in Experimental Brain Tumors

Cited by 9 publications

References 6 publications

Management of brain metastases from breast cancer by combination chemotherapy

Management of brain metastases from breast cancer by combination chemotherapy

Circulatory Factors in the Carbohydrate Metabolism of an Experimental Glial Neoplasm*

Perspectives on Brain Tumor Formation Involving Macrophages, Glia, and Neural Stem

Contact Info

Product

Resources

About