Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives

Incel, P.; Gürel, Mehmet Salih; Erdemir, Aslı Vefa

doi:10.1111/srt.12197

Cited by 18 publications

(14 citation statements)

References 24 publications

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“…In the present study, the sensitivity and specificity of the RCM features on the dorsal tongue were lower compared with other sites, such as lips and buccal mucosa, due to the disturbance of the tongue papillae and taste buds. Hyperkeratosis and acanthosis also interfere with the display resolution of RCM (27). The features of RCM are difficult to identify in the deeper layer of the sections due to fact the upper tissue layer interferes with image formation (28).…”

Section: Discussionmentioning

confidence: 99%

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

et al. 2020

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Reflectance confocal microscopy (RCM) is a non-invasive tool that provides real-time microscopic images and relatively high-resolution tissue images. This technique provides a link between clinical examination and histopathology. RCM has been used to detect skin diseases and has also recently been applied to diseases of the oral mucosa. The present study aimed to explore the features of oral lichen planus (OLP) using RCM. A total of 47 patients with OLP exhibiting a reticular pattern, were included in the present study. The lesion sites and healthy adjacent sites were examined using in vivo RCM, with the lesion being histopathologically confirmed after RCM examination. The confocal images were reviewed, and the features were described. Sensitivity and specificity analysis of the RCM features was also performed. RCM examination presented parakeratosis, acanthosis and connective tissue papillae disappearance, with the presence of large melanocytes and roundish inflammatory cell infiltration, as well as dilated vessels in the lesion tissue. The sensitivity and specificity of OLP for dorsal tongue lesions were not as satisfactory as those on other sites. The results implied that RCM may be a promising technique to detect OLP non-invasively in vivo.

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Section: Discussionmentioning

confidence: 99%

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

et al. 2020

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“…The vascular structure was described in numerous studies (34). Therefore, the vascular morphology was defined as 6 types of vessels: straight linear, curved linear, tubular/canalicular round and polymorph and branching vessels.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive imaging techniques for the in�vivo diagnosis of Bowen's disease: Three case reports

et al. 2019

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Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. There are no very specific dermoscopic criteria for the diagnosis of this disease, but some dermoscopic features (scaly surface, vascular structures and pigmentation) can be found more frequent and can be helpful for the diagnosis. RCM of BD shows an acanthotic epidermis with two types of targetoid cells: the first, a large cell with bright center and dark peripheral halo, the second, a cell with dark center and a bright rim surrounded by a dark hallo, related with dyskeratotic cells on histological examination. BD management could be improved by using non-invasive, in vivo imaging techniques that allow a fast and easy diagnosis and can be used as follow-up tools. However, larger studies are necessary for the validation of our observations.

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“…RCM is a non-invasive real-time technique that has been useful in the diagnosis of skin cancer and inflammatory skin diseases. Recently, multiple hypopigmented lesions have been described by means of RCM (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) trying to help clinicians to decide confidently whether a pink lesion should be biopsied. Thus, techniques such as RCM may avoid unnecessary biopsies and allow monitoring of the response to non-invasive treatments, such as photodynamic therapy, topical imiquimod, ingenol mebutate gel, topical diclofenac or topical 5-fluorouracil (29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation

Gómez‐Martín¹,

Moreno²,

Duran³

et al. 2018

Acta Derm Venerol

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Pink flat skin lesions on the legs in elderly people represent a diagnostic challenge due to the paucity of clinical and dermoscopic evidence. A prospective study of 114 pink flat lesions on the legs of 85 elderly patients was performed to describe the utility of reflectance confocal microscopy in this clinical context. Evaluation of clinical, dermoscopic and confocal parameters and calculation of diagnostic accuracy/sensitivity/specificity for non-melanoma skin cancer diagnosis of each technique were carried out. Thirty-four benign and 80 malignant neoplasms were analysed. A correct clinical diagnosis was established in 49.1% of cases (sensitivity 68.7%, specificity 73.5%). Dermoscopy achieved 59.6% correct diagnosis (sensitivity 85%, specificity 67.6%) and confocal microscopy evaluation after clinical and dermoscopic evaluation rendered a correct diagnosis in 85.1% of cases (sensitivity 97.5%, specificity 88.2%). Confocal microscopy may improve diagnostic accuracy, sensitivity and specificity as a secondary evaluation after dermoscopy. A diagnostic confocal algorithm for pink flat lesions on the legs is proposed.

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Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives

Abstract: Vascular properties can be evaluated in the diagnosis of nonpigmented tumoral skin lesions via RCM.

Cited by 18 publications

References 24 publications

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

Non-invasive imaging techniques for the in�vivo diagnosis of Bowen's disease: Three case reports

Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation

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Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives

Abstract: Vascular properties can be evaluated in the diagnosis of nonpigmented tumoral skin lesions via RCM.

Cited by 18 publications

References 24 publications

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47&nbsp;cases in a Chinese cohort

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47&nbsp;cases in a Chinese cohort

Non-invasive imaging techniques for the in�vivo diagnosis of Bowen's disease: Three case reports

Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation

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Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort

Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort