Vascular mechanics of the coronary artery

Veress, Alexander I.; Vince, D. G.; Anderson, Peter M.; Cornhill, J. Fredrick; Herderick, Edward E.; Klingensmith, Jon D.; Kuban, Barry D.; Greenberg, Neil L.; Thomas, James D.

doi:10.1007/s003920070106

Cited by 55 publications

(46 citation statements)

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“…In particular responses to hypertension have been studied extensively [2], [4], [5], [6], [7], [8], [9]). These changes in wall properties occur both locally and globally.…”

mentioning

confidence: 99%

Viscoelastic Mapping of the Arterial Ovine System using a Kelvin Model

Valdez‐Jasso¹,

Haider²,

Banks³

et al. 2007

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The mechanics of the arterial wall is complex, due to its material structure and load conditions, which influence the hemodynamic properties as well as the growth and remodeling process of the cardiovascular system. Arterial remodeling can be found both locally and globally. Local remodeling is typically a result of disease, while global remodeling can be found even for healthy arteries. In this study we have analyzed how elastic and viscoelastic properties differ across 7 locations along the large ovine arteries in 11 sheep. We combined the Kelvin model with experimental measurements of vessel diameter and pressure obtained in-vitro at conditions mimicking the in-vivo dynamics. Elastic and viscoelastic wallproperties were assessed by analyzing values of four model parameters across the 7 locations. To do so we solved an inverse problem, resulting in computed estimates for each of the four parameter values that minimize the residual between the data and the model. We used sensitivity analysis to compute standard errors, and confidence intervals for all model parameters. Results showed that while elastic properties including Young's modulus and the vessel wall thickness varied across locations (smaller arteries were stiffer than larger arteries) viscoelastic relaxation parameters did not differ significantly across locations. We also showed that for all locations, the inclusion of viscoelastic behavior, e.g., using the Kelvin model, is important to capture pressure-area dynamics.

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“…In particular responses to hypertension have been studied extensively [2], [4], [5], [6], [7], [8], [9]). These changes in wall properties occur both locally and globally.…”

mentioning

confidence: 99%

Viscoelastic Mapping of the Arterial Ovine System using a Kelvin Model

Valdez‐Jasso¹,

Haider²,

Banks³

et al. 2007

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“…IVUS can be used to find mechanical and morphological information about plaques. Previously the IVUS was used in the first portion of a study by Veress et al (2000) to find the creep and quasistatic stress/strain responses of porcine coronary arteries. The FEA was done using Sepran software.…”

Section: Demand and Complexities In Standardizing Vulnerable Plaque Riskmentioning

confidence: 99%

“…Many researchers have included calcium in their FEM (Lee 2000, Huang et al 2001, Tang et al 2005, Veress et al 2000and Li et al 2005, 2007b. The following articles can be examined to find a clearer picture of the effect of calcium on rupture stresses.…”

Section: Calcification and Feamentioning

confidence: 99%

“…P in = 150 mm Hg are shown. Veress et al (2000) used FEA to find changes in plaque stress "as a function of lesion development, and changes in the material properties of lipid pool and plaque cap." While making a linear comparison between age and atherosclerotic plaque state is near impossible, the findings of the study are useful.…”

Section: Calcification and Feamentioning

confidence: 99%

“…The following values were used for the elastic modulus: (2000) hypothesized that calcium near the surface of the plaque would increase the shoulder stress and cause higher stress on the cap itself. Veress et al (2000) concluded that calcium might play a part in plaque rupture.…”

Section: Calcification and Feamentioning

confidence: 99%

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The Effect of Calcified Plaque on Stress within a Fibrous Thin Cap Atheroma in an Atherosclerotic Coronary Artery Using Finite Element Analysis (FEA)

Nagy¹

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By varying the percentage of calcium and lipid within a defined region, the stress on the cap was estimated using an idealized finite element arterial model. Also the thickness of the fibrous cap was varied to determine whether the stress was solely a function of lipid percentage or a combination. Plaque, arterial wall, lipid, and calcium were modeled using linear elastic, isotropic, and incompressible material properties. The first test varied the thin cap thickness from 65 to 500 microns and tested the calcified lipid model at varying lipid/calcium percentages. The lipid/Calcium pool increased/decreased 10% each test. As the cap thickness becomes thinner than 100 microns, the stress level increases rapidly. The second test compared a model with lipid pool and calcium behind the lipid with a thin cap of 65 microns to a model with lipid pool of the same size and thin cap of 65 microns but only fibrous tissue surrounding (no calcium). The lipid pool increased from 10 to 90% lipid. The result of this test found that at higher lipid percentages, the calcium increased the stress on the cap. By understanding the material properties of plaque and the structure of the lesion, future developments may be able to evaluate rupture risk. This idealized study illustrates the ability of computation models to provide insight into clinical situations.

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Pulse Wave for Arterial Diagnostics

2022

Pressure Oscillation in Biomedical Diagnostics and Therapy

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Vascular mechanics of the coronary artery

Abstract: Studying the solid mechanics of the arterial wall and the atheroma provide important insights into the mechanisms involved in plaque rupture.

Cited by 55 publications

References 0 publications

Viscoelastic Mapping of the Arterial Ovine System using a Kelvin Model

Viscoelastic Mapping of the Arterial Ovine System using a Kelvin Model

The Effect of Calcified Plaque on Stress within a Fibrous Thin Cap Atheroma in an Atherosclerotic Coronary Artery Using Finite Element Analysis (FEA)

Pulse Wave for Arterial Diagnostics

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