Vascular-Leukocyte Interactions

Hazan, Aleah; Smith, Samantha D.; Jones, Rebecca L.; Whittle, Wendy; Lye, Stephen J.; Dunk, Caroline

doi:10.2353/ajpath.2010.091105

Cited by 138 publications

(69 citation statements)

References 42 publications

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“…It must be noted that we did not formally establish that decidual macrophages have the capacity to migrate within our cultures; however, others have observed decidual macrophage migration in similar first-trimester organ cocultures of decidua and placental villi (48). Furthermore, the impairments in macrophage migration within decidual tissue are in line with previous work by Redline and colleagues, who demonstrated that macrophages do not localize near infectious foci in the deciduas of artificially decidualized and pregnant mice (6,23,28).…”

Section: Discussionmentioning

confidence: 99%

Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis

et al. 2017

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The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to the placenta and fetus. Host-pathogen interactions in the decidua during this early stage of infection remain poorly understood. Here, we assessed the dynamics of L. monocytogenes infection in primary human decidual organ cultures and in the murine decidua in vivo. A high inoculum was necessary to infect both human and mouse deciduas, and the data support the existence of a barrier to initial colonization of the murine decidua. If successful, however, colonization in both species was followed by significant bacterial expansion associated with an inability of the decidua to mount appropriate innate cellular immune responses. The innate immune deficits included the failure of bacterial foci to attract macrophages and NK cells, cell types known to be important for early defenses against L. monocytogenes in the spleen, as well as a decrease in the tissue density of inflammatory Ly6C hi monocytes in vivo. These results suggest that the infectivity of the decidua is not the result of an enhanced recruitment of L. monocytogenes to the gestational uterus but rather is due to compromised local innate cellular immune responses.KEYWORDS Listeria monocytogenes, decidua, placenta T he pregnant uterus is a dynamic organ that supports fetoplacental growth, with many trophic functions provided by the decidua, the specialized endometrial tissue that encases the conceptus (1). The decidua also provides a unique immunological environment that blocks the maternal immune system from recognizing the conceptus as a foreign tissue and rejecting it as if it were a solid-organ transplant (2). As a consequence, this environment would be expected to provide opportunities for pathogens to infect the maternal-fetal interface. Indeed, infection of the decidua is now considered to be a critical first step in the hematogenous transmission of a variety of pathogens from mother to fetus (3-7). One such organism is the facultative, intracellular, Gram-positive bacterium Listeria monocytogenes, a clinically relevant foodborne pathogen that can cause severe disease in pregnant women. Once L. monocytogenes reaches the placenta, there are increased risks of severe maternal disease and pregnancy complications, including preterm labor and devastating fetal/neonatal morbidity and mortality (8, 9).Because of its experimental tractability, L. monocytogenes is an excellent model

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Section: Discussionmentioning

confidence: 99%

Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis

et al. 2017

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“…Macrophages and dNK cells can also produce many MMPs, such as MMP7 and -9 (Smith et al 2009), which along with pro-and anti-angiogenic factors such as VEGF, PGF and angiopoietins could influence vessel stability. Recent studies using placentaldecidual co-culture model have implicated MMP2 and -9 in the remodelling events initiated by leukocytes (Hazan et al 2010). Studies have indicated that dNK cells begin to disperse after spiral artery remodelling is complete, and are found in much reduced numbers at term (Williams et al 2009b).…”

Section: Factors Involved In Spiral Artery Remodellingmentioning

confidence: 99%

Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

Cartwright¹,

Fraser²,

Leslie³

et al. 2010

Reproduction

238

144

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In human pregnancy, successful placentation and remodelling of the uterine vasculature require the integration of a number of stages, which are crucial for a healthy pregnancy. As the demands of the developing fetus for nutrients and oxygen increase, the capacity of the maternal blood vessels to supply this must be altered radically, with deficiencies in this process implicated in a number of dangerous pregnancy complications. The complex signalling networks that regulate these tightly co-ordinated events are becoming clearer as more studies of early pregnancy are performed. It is the aim of this review to draw together our knowledge of events that occur to facilitate a successful pregnancy ranging from the preparation for implantation, through the invasion and differentiation of the trophoblast and the regulation of these processes by other cells within the decidual environment, to the active role that the trophoblast and maternal immune cells play in facilitating the remodelling of the uterine spiral arteries. The events involved in a healthy pregnancy will then be compared to aberrant placentation and remodelling, which are characteristics of many pregnancy disorders, and recent advances in detection of abnormal placental development will also be discussed.

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“…In humans, loss of vascular smooth muscle cells is accompanied by the influx of EVTs to envelope the arteries. These vessel-associated EVTs deposit extracellular matrix called fibrinoid that stabilizes the dilated, R94 M T Rätsep and others venous-like vessels (Smith et al 2009, Hazan et al 2010, Cerdeira & Karumanchi 2012, Robson et al 2012, Wallace et al 2012. The dogma currently held is that modified SAs are no longer under maternal vasomotor control.…”

Section: Roles Of Nk Cells In Physiological Changes To Maternal Samentioning

confidence: 99%

Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis

et al. 2015

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Mammalian pregnancy involves tremendous de novo maternal vascular construction to adequately support conceptus development. In early mouse decidua basalis (DB), maternal uterine natural killer (uNK) cells oversee this process directing various aspects during the formation of supportive vascular networks. The uNK cells recruited to early implantation site DB secrete numerous factors that act in the construction of early decidual vessels (neoangiogenesis) as well as in the alteration of the structural components of newly developing and existing vessels (pruning and remodeling). Although decidual and placental development sufficient to support live births occur in the absence of normally functioning uNK cells, development and structure of implantation site are optimized through the presence of normally activated uNK cells. Human NK cells are also recruited to early decidua. Gestational complications including recurrent spontaneous abortion, fetal growth restriction, preeclampsia, and preterm labor are linked with the absence of human NK cell activation via paternally inherited conceptus transplantation antigens. This review summarizes the roles that mouse uNK cells normally play in decidual neoangiogenesis and spiral artery remodeling in mouse pregnancy and briefly discusses changes in early developmental angiogenesis due to placental growth factor deficiency.Reproduction (2015) 149 R91-R102

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Vascular-Leukocyte Interactions

Cited by 138 publications

References 42 publications

Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis

Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis

Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis

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