Vascular Lesions due to Obstruction of the Vasa Vasorum

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

“…Furthermore, in different animal models either occlusion or removal of adventitial vasa vasorum has been shown to cause intimal hyperplasia. This finding is probably related to hypoxia of the arterial wall (6,22,23) which regresses with generation of a new adventitial layer (24). A reduction of coronary artery vasa vasorum during regression of atherosclerosis has been demonstrated (4).…”

“…Volume-rendered transmission displays, maximum intensity projection, and voxel gradient shading were displayed at various angles and threshold values of voxels. Average voxel size was [21][22][23][24][25][26][27][28] m, and images of up to 800 slices were rendered for each arterial specimen (each with a matrix of 10-20 m cubic voxels ϫ 16 bits of gray scale).…”

150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein.

“…Chronic and intermittent hypoperfusion in arterial wall, resulting in insufficient delivery of nutrients to vascular cells, is believed to contribute to the pathogenesis of atherosclerotic lesions (27)(28)(29)(30). One important facet of this ischemic milieu is oxygen deprivation in the vascular microenvironment (31).…”

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

“…[18][19][20] Adventitial irritation results in focal intimal thickening, and markers applied to the adventitia can be visualized in intima. It is hypothesized that cells originating from the adventitial layer migrate and contribute to neointimal formation.…”