Vascular involvement in Behçet’s disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin

Espinosa, Gerard; Font, Josep; Tàssies, Dolors; Vidaller, Antonio; Deulofeu, R.; López‐Soto, Alfons; Cervera, Ricard; Ordinas, A; Ingelmo, M; Reverter, Joan Carles

doi:10.1016/s0002-9343(01)01048-8

Cited by 157 publications

(110 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus far no consistent primary coagulation or fibrinolytic system abnormalities have been identified in BD [38,39]. Because venous inflammation is probably the cause of deep vein thrombosis in patients with BD [40], an immunosuppressive approach to management seems reasonable, although no large randomized controlled trials have directly addressed this issue.…”

Section: Discussionmentioning

confidence: 99%

Behçet's disease in Budd-Chiari Syndrome

et al. 2013

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Behçet's disease in Budd-Chiari Syndrome

et al. 2013

View full text Add to dashboard Cite

“…Previously, abnormalities in the coagulation cascade, such as significantly higher levels of tissue plasminogen activator in patients with BD compared with healthy age-matched controls, have been reported. [44][45][46] Moreover, high levels of serum concentration of von Willebrand factor (vWF, an endothelial product that is shown in yellow in Figure 4), plasminogen activator inhibitor-1, and thrombomoduline were found in patients with BD. 47,48 Along this line, Demirer et al, 46 Ozoran et al, 47 and Beyan et al 49 showed that the level of vWF was significantly higher in patients with BD, supporting endothelial destruction because of vasculitis related with BD.…”

Section: Focal Adhesionmentioning

confidence: 99%

Identification of possible pathogenic pathways in Behçet’s disease using genome-wide association study data from two different populations

et al. 2014

View full text Add to dashboard Cite

Behc¸et's disease (BD) is a multi-system inflammatory disorder of unknown etiology. Two recent genome-wide association studies (GWASs) of BD confirmed a strong association with the MHC class I region and identified two non-HLA common genetic variations. In complex diseases, multiple factors may target different sets of genes in the same pathway and thus may cause the same disease phenotype. We therefore hypothesized that identification of disease-associated pathways is critical to elucidate mechanisms underlying BD, and those pathways may be conserved within and across populations. To identify the disease-associated pathways, we developed a novel methodology that combines nominally significant evidence of genetic association with current knowledge of biochemical pathways, protein-protein interaction networks, and functional information of selected SNPs. Using this methodology, we searched for the disease-related pathways in two BD GWASs in Turkish and Japanese case-control groups. We found that 6 of the top 10 identified pathways in both populations were overlapping, even though there were few significantly conserved SNPs/genes within and between populations. The probability of random occurrence of such an event was 2.24E À39. These shared pathways were focal adhesion, MAPK signaling, TGF-b signaling, ECM-receptor interaction, complement and coagulation cascades, and proteasome pathways. Even though each individual has a unique combination of factors involved in their disease development, the targeted pathways are expected to be mostly the same. Hence, the identification of shared pathways between the Turkish and the Japanese patients using GWAS data may help further elucidate the inflammatory mechanisms in BD pathogenesis.

show abstract

“…Behçet's disease associated with the presence of vascular lesions as accessory symptoms is known as vascular Behçet's disease and is said to account for 10%-25% of the total case of Behçet's disease. 4) It is thought to affect arteries and veins of all sizes. In most cases, aneurysms are saccular and form punch-out pseudoaneurysms; therefore, once they form, they often rapidly increase in size and then rupture.…”

Section: Discussionmentioning

confidence: 99%

Single-Stage Endovascular Treatment Performed on Multiple Aortic Aneurysms in a Patient with Behçet’s Disease—Report of a Case

Saiki

Nakamura

Fujiwara

et al. 2013

Annals of Vascular Diseases

View full text Add to dashboard Cite

A 50-year-old male diagnosed with Behçet's disease was referred to our department for stent graft treatment because of thoracic, abdominal, and right common iliac artery (CIA) aneurysms. He had a superior mesenteric artery aneurysm in 2005 that was treated with resection and bypass surgery through the radial artery. He later underwent four abdominal surgical procedures for conditions such as intestinal perforation and ileus. Stent graft treatment was performed. The postoperative course was uneventful; postoperative computed tomography (CT) showed no apparent endoleak, while that performed at 3 years post-discharge showed that the aneurysms had decreased in size.

show abstract

Vascular involvement in Behçet’s disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin

Cited by 157 publications

References 43 publications

Behçet's disease in Budd-Chiari Syndrome

Behçet's disease in Budd-Chiari Syndrome

Identification of possible pathogenic pathways in Behçet’s disease using genome-wide association study data from two different populations

Single-Stage Endovascular Treatment Performed on Multiple Aortic Aneurysms in a Patient with Behçet’s Disease—Report of a Case

Contact Info

Product

Resources

About