Vascular Invasion and Tumor Stage Are Independent Prognosticators of Lymph Node (Ln) Metastasis in Squamous Penile Cancer (Spc)

Morgenstern, Nora; Slaton, Joel W.; Levy, David A.; Ayala, Alberto G.; Santos, Misael Wanderley; Pettaway, Curtis A.

doi:10.1097/00005392-199904010-00636

Cited by 4 publications

(1 citation statement)

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“…The incidence of occult lymph‐node metastases in clinically node‐negative cases is 10–15%[3]. The depth of invasion, tumour grade, vascular and lymphatic involvement are the most important risk factors related to the occurrence of nodal metastases in penile carcinoma [4–8]. Inguinal lymphadenectomy is associated with a high morbidity rate of 30–68%[1,9,10].…”

Section: Introductionmentioning

confidence: 99%

Expression of Ki‐67 in squamous cell carcinoma of the penis

Berdjis¹,

Meye²,

Nippgen³

et al. 2005

BJU International

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OBJECTIVE To investigate the Ki‐67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis. PATIENTS AND METHODS We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow‐up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin‐biotin method. The mean Ki‐67 LI was defined as the percentage of total tumour cells that were Ki‐67‐positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression. RESULTS The mean (range) Ki‐67 LI was 40.5 (6.4–93.0)%; a high mean Ki‐67 LI was significantly inversely correlated with tumour differentiation (P < 0.005) and there was a tendency for a high Ki‐67 LI to be associated with advanced local tumour stage, nodal metastasis and clinical disease progression, but these correlations were not statistically significant (P = 0.07, 0.07 and 0.06, respectively). CONCLUSIONS The Ki‐67 LI is correlated with tumour grade in penile cancer, and may indicate a greater risk of nodal metastasis.

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Section: Introductionmentioning

confidence: 99%