Vascular intramural strain imaging using arterial pressure equalization

Renal Advances in Ultrasound Elasticity Imaging: Measuring the Compliance of Arteries and Kidneys in End-Stage Renal Disease

“…To understand how surrounding tissue can infl uence elastic modulus reconstruction, a simple model has been used [21] in which surrounding tissue is viewed as a continuous medium with a fi xed elastic modulus (E 2 ) and the artery wall is considered homogeneous with a different elastic modulus (E 1 ) while generating intramural strain ( ⌬ ) due to pulse pressure ( ⌬ p): a is the lumen radius, b is the outer radius of the artery, and r is the strain measurement point. Both in vivo measurements presented in this study, as well as a large body of previous literature [4,16,19,31] , suggest that the nonlinear change in arterial elastic modulus with changing transmural pressures can be modeled as an exponential function.…”

“…In previous reports on arterial elasticity over a wide range of intraluminal pressures [18,19] , the compliance was inferred from geometric changes such as artery diameter and lumen cross-section based on a numerical model [20] . However, the precision of speckle tracking offers the possibility of being able to detect subtle underlying structural changes within the vascular wall and measure the corresponding intramural changes in elastic properties with unprecedented resolution, precision and accuracy [21] .…”

Robustness of reconstructing the Young’s modulus distribution of vulnerable atherosclerotic plaques using a parametric plaque model

“…Therefore, any imaging modality capable of measuring strain elastograms can be used. Our reconstruction method may potentially also be applied in other clinically relevant situations where circular-like objects (e.g., plaques or tumors) are present in an approximately homogeneous medium that is strained (e.g., superficial atherosclerotic arteries, such as the carotid or femoral, Kim et al 2004;or even breast tumors, Liu et al 2003;Wellman and Howe 1999), both after appropriately modifying the PFEM inner and/or outer boundary.…”

Young’s modulus reconstruction of vulnerable atherosclerotic plaque components using deformable curves

“…Consequently, any imaging modality that allows the processing of strain elastograms can be used (Plewes et al 2000;Rogowska et al 2004). Finally, our reconstruction method may potentially also be applied in other clinically relevant situations where relatively softer/stiffer objects, such as plaques or tumors, are present in an approximately homogeneous medium that is deformed (e.g., superficial arteries, such as the carotid or femoral) (Kim et al 2004), or breast tumors (Liu et al 2003, Wellman andHowe 1999).…”