Vascular hemichorea/hemiballism and topiramate

Gatto, Emilia; Roca, Claudia Uribe; Raina, Gabriela; Gorja, Marcelo; Folgar, Silvia; Micheli, Federico

doi:10.1002/mds.20086

Cited by 27 publications

(9 citation statements)

References 15 publications

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“…inhibition of calcium release from intraneuronal stores, modulation of GABA- and glycin-gated currents) and have been reported to be useful in the management of patients with hemichorea/hemiballism [45], vascular hemichorea/hemiballism [46,47] and vascular generalized chorea [48]. …”

Section: Hemichorea-hemiballism Dystoniamentioning

confidence: 99%

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Siniscalchi¹,

Gallelli²,

Labate³

et al. 2012

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Involuntary abnormal movements have been reported after ischaemic and haemorrhagic stroke. Post stroke movement disorders can appear as acute or delayed sequel. At the moment, for many of these disorders the knowledge of pharmacological treatment is still inadequate. Dopaminergic and GABAergic systems may be mainly involved in post-stroke movement disorders. This article provides a review on drugs commonly used in post-stroke movement disorders, given that some post-stroke movement disorders have shown a partial benefit with pharmacological approach.

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Section: Hemichorea-hemiballism Dystoniamentioning

confidence: 99%

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Siniscalchi¹,

Gallelli²,

Labate³

et al. 2012

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“…Its advantage over other neuroleptics is the lack of EPS in spite of longterm use 8. Only few case reports have described partial effect of topiramate on control of hemichorea 9,10. We report a case of intractable hemichorea which was controlled with anti-convulsant, topiramate.…”

Section: Discussionmentioning

confidence: 95%

A Case of Vascular Hemichorea Responding to Topiramate

Kim

Jung²,

Kim³

et al. 2009

JMD

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Although vascular chorea often comes into remission spontaneously, a few patients may remain with persistent movement disorder. Most movements respond well to neuroleptics as well as other antidopaminergic drugs, but some patients show poor responses to those neuroleptics. Topiramate is a widely used of broad-spectrum anticonvulsant possessing a complex mechanism of action. It has been proven to enhance gamma-aminobutyrate acid activity and to be effective in the control of other movement disorders. We describe a 63-year-old woman with intractable vascular hemichorea which was controlled with anti-convulsant, topiramate.

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“…Carbamazepine can also reduce the choreiform movements in some patients through the stabilization of inactivated state of voltage-gated sodium channels [74, 75, 77]. The newer AEDs, may represent an alternative in the treatment of paroxysmal kinesiogenic choreoathetosis; in fact, gabapentin and levetiracetam have been reported to be useful in the management of patient with hemichorea/hemiballism [78, 79], while topiramate is reported to improve both vascular hemichorea/hemiballism [80, 81] and vascular generalized chorea [55]. Moreover, recently Vlas and co-workers [50] described the efficacy of levetiracetam (start dose of 2.5mg⁄kg⁄day, titrated to a final dose of 10mg⁄kg⁄day) to reduce choreoathetosis in two patients with dyskinetic cerebral palsy, without the development of side effects.…”

Section: Drugs Treatment Of Hyperkinetic Movement Disordersmentioning

confidence: 99%

Use of Antiepileptic Drugs for Hyperkinetic Movement Disorders

Siniscalchi

Gallelli²,

Sarro³

2010

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Many studies investigated the use of antiepileptic drugs (AEDs) in several neurological diseases other than epilepsy. These neurological disorders, usually, involve neuronal excitability through the modulating of ion channels, receptors and intracellular signaling pathways, and are the targets of the AEDs. This article provides a review of the clinical efficacy of both conventional and newer AEDs in hyperkinetic movement disorders. Some of these indications for AEDs have been established, while others are under investigation. The modulation of GABAergic transmission may explain the neuronal hyper-excitability that underlies some forms of hyperkinetic movement disorders. So, AEDs able to increase GABAergic neurotransmission may play a role in hyperkinetic movement disorders treatment. Therefore, AEDs could represent a useful therapeutic option in the management of hyperkinetic movement disorders where the available treatments are ineffective.

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Vascular hemichorea/hemiballism and topiramate

Cited by 27 publications

References 15 publications

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

A Case of Vascular Hemichorea Responding to Topiramate

Use of Antiepileptic Drugs for Hyperkinetic Movement Disorders

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