Vascular hamartomas in childhood

Willshaw, H E; Deady, J P

doi:10.1016/s0022-3468(87)80348-2

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Not until 1979 did Kushner first describe in detail the use of IS in periocular hemangiomas 12 . Since then, many reports of periorbital hemangiomas treated with IS have appeared in the ophthalmologic, surgical, and pediatric literature 13–24 …”

Section: Discussionmentioning

confidence: 99%

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Intralesional Steroids in Cutaneous Hemangioma

Reyes

Vázquez-Botet

Capó

1989

The Journal of Dermatologic Surgery and Oncology

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Cutaneous hemangiomas are present in 2.6% of all newborn children. Conservative management is the preferred method of treatment, and only cases with a high risk of complications should be treated. Periocular cutaneous hemangiomas have been associated with ophthalmic complications in 41%-100% of such cases. Intralesional steroids are frequently used by ophthalmologists for treatment of periocular hemangiomas. We present a case of cutaneous hemangioma treated with this modality. No previous cases have been reported in the dermatologic literature. A review, description, and complications of the use of intralesional steroids in hemangiomas are included.

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Section: Discussionmentioning

confidence: 99%

“…Transient complications without permanent sequelae may also occur. Swelling frequently occurs immediately after injection, but disappears in the first 12–24 hours 18,24 . At times, whitish corticosteroid subcutaneous deposits are noted, but disappear within 2 months after injection 18 .…”

Section: Discussionmentioning

confidence: 99%

Intralesional Steroids in Cutaneous Hemangioma

Reyes

Vázquez-Botet

Capó

1989

The Journal of Dermatologic Surgery and Oncology

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“…Willshaw and Deady published a study in 1987 with 13 periorbital capillary haemangioma patients treated with intralesional steroids, but without specifying intraorbital versus extraorbital involvement. 36 Deady and Willshaw published a study in 1986 of 24 patients with periorbital haemangiomas, of whom nine were treated with intralesional steroids. 37 Refractive error for a subset of patients was measured before treatment, but no objective end points were measured after treatment.…”

Section: Resultsmentioning

confidence: 99%

Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence

Ranchod

Frieden

Fredrick

2005

British Journal of Ophthalmology

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Aim: To systematically review the literature for corticosteroid treatment of periorbital haemangioma of infancy (HOI) and determine the relative efficacy and safety of oral, topical and intralesional corticosteroids. Methods: PubMed and the Cochrane Library were queried using keywords, and further articles were obtained by reviewing bibliographies. Inclusion and exclusion criteria were applied to create a subset of literature for analysis. Results: Systematic review revealed 81 original reports of periorbital HOI cases treated with steroids. Most studies and case series failed to document refractive error or visual acuity before and after treatment. Of cases meeting inclusion criteria, five patients received topical steroids and 25 patients received intralesional steroids. Patients receiving intralesional injections tended to demonstrate reduced astigmatism at follow up after treatment (21 of 28). The lack of studies with relevant objective ophthalmological end points prevented statistical meta-analysis. Conclusion: Intralesional injections may reduce refractive error, while the efficacy of topical steroids is unclear. Studies measuring objective ophthalmic data before and after treatment are sparse, and more studies are needed to determine the relative efficacy of different steroids. There are insufficient data to estimate the incidence of steroid side effects in patients treated with steroids for periorbital HOI or complications of intralesional injections in particular.

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“…The natural course of an infantile cutaneous hemangioma consists of rapid growth during the first year of life, followed by a slow involution that may last 5-7 years [3,9,25]. The study of the natural course of a subglottic hemangioma is impeded by the need for intervention, but most authors agree that it shows a similarly rapid growth until 6 -12 months of age [12,15], followed by involution after 18 or more months [6,15,19].…”

Section: Discussionmentioning

confidence: 99%

Management of infantile subglottic hemangioma: laser vaporization, submucous resection, intubation, or intralesional steroids?

Hoeve

Küppers

Verwoerd

1997

International Journal of Pediatric Otorhinolaryngology

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The infantile subglottic hemangioma can be treated in various ways. The results of the treatment used in the Sophia Children's Hospital, intralesional steroids and intubation (IS + I), are discussed and compared with the results of other current treatment methods: CO2 laser vaporization, submucous resection and intubation alone. A total of 18 infants were treated for subglottic hemangioma in our hospital: ten with IS + I alone, five were first treated with systemic therapy and later with IS + I alone and three with various therapies. IS + I was effective in 14 of the 15 patients, one patient was lost from follow up. The remaining three infants were treated with (combinations of) various therapies, because IS + I failed or was not tried. Two patients were finally cured, one still has a tracheotomy. Of other current therapies, CO2 laser vaporization is reported to be effective. In all 30% of the infants treated in Boston Children's Hospital with CO2 laser needed a tracheotomy. Moreover subglottic stenosis is a serious complication. Submucous resection is often successful. It may be complicated by subglottic stenosis and in some cases, depending on the localization of the hemangioma, it may be contraindicated. Intubation alone is less effective than intubation combined with intralesional steroids. Management of subglottic hemangioma in Sophia Children's Hospital is primarily intralesional steroids and intubation and secondarily submucous resection or tracheotomy. CO2 laser vaporization is seldom applied because of the risk of subglottic stenosis.

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Vascular hamartomas in childhood

Cited by 10 publications

References 7 publications

Intralesional Steroids in Cutaneous Hemangioma

Intralesional Steroids in Cutaneous Hemangioma

Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence

Management of infantile subglottic hemangioma: laser vaporization, submucous resection, intubation, or intralesional steroids?

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