Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension

Abstract

Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelial growth factor (VEGF), which contributes to the progress of angiogenesis, is reported to be inversely associated with the minor allele of polymorphism rs3025039, the minor allele of rs3025039 could be inversely associated with atherosclerosis among individuals with hypertension. A cross-sectional study of 1793 older Japanese adults aged 60–89 years with hypertension who participated in general health check-ups was conducted. Atherosclerosis was defined as carotid intima-media thickness (CIMT) ≥ 1.1 mm. The minor allele of polymorphism rs3025020 was positively associated with VEGF. Therefore, in addition to known cardiovascular risk factors, rs3025020 genotype acted as a confounding factor in the present study. Independent of known confounding factors, the minor allele of rs3025039 was inversely associated with atherosclerosis among older Japanese adults with hypertension. The fully adjusted odds ratio (OR) and 95% confidence interval (CI) for atherosclerosis with the minor allele of rs3025039 was 0.78 (0.64, 0.96). The angiogenesis-related polymorphism rs3025039 was associated with the development of atherosclerosis among older Japanese individuals. This study indicates that the development of atherosclerosis among older individuals might partly indicate a capacity for angiogenesis.

Tissue Factor and Vascular Endothelial Growth Factor in Detecting Thromboembolic Complications in Diabetic Atherosclerotic Patients

“… 14 VEGF, which has been shown to have multipotent effects in experimental studies, may be a determining factor in atherosclerosis as well as a clinically helpful factor in staging. 26 – 28 …”

VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study

“…Serum concentration of VEGF was reported to be inversely associated with the (T) allele of the VEGF polymorphism rs3025039 and positively associated with the (T) allele of the VEGF polymorphism rs3025020 [ 14 ]. Moreover, rs3025020 is inversely associated with hypertension [ 19 ] and rs3025039 is inversely associated with structural atherosclerosis as evaluated by CIMT among older individuals with hypertension [ 15 ].…”

“…HTLV-1 infected cells might not have increased levels of VEGF in individuals in the early stages of HTLV-1 infection. Serum VEGF concentration is reported to be inversely associated with the (T) allele of the VEGF polymorphism rs3025039 [ 14 ], which is inversely associated with structural atherosclerosis among older individuals with hypertension [ 15 ]. Because serum VEGF concentration has been reported to be positively associated with the (T) allele of the VEGF polymorphism rs3025020 [ 14 ], VEGF polymorphism rs3025020 could act as a confounder of the association between VEGF polymorphism rs3025039 and HTLV-1.…”

Association of endometriosis with cardiovascular disease: Genetic aspects (Review)

“…The results of the literature research revealed that the VEGF rs1570360 and rs3025039 SNPs ( 107 - 111 ), ESR1 (or ER-alpha ) rs9340799 ( 112 , 113 ), IL-6 rs1800796 ( 114 , 115 ), IL-10 rs1800871 ( 116 - 118 ), IL-16 rs11556213 ( 9 , 16 , 119 ), 5,10 methylenetetrahydrofolate reductase ( MTHFR ) rs1801133 (Ala222Val) ( 120 , 121 ), C-C motif chemokine ligand 21 ( CCL21 ) rs2812378 ( 122 , 123 ), rs507666 at ABO /9q34.2 ( 124 , 125 ) and tumor protein p53 ( TP53 ) rs1042522 ( 126 , 127 ) are associated with both diseases under investigation ( Table I ).…”