Vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF-2) as potential regulators of seasonal reproductive processes in male European bison (Bison bonasus, Linnaeus 1758)

Tabęcka-Łonczyńska, Anna; Mytych, Jennifer; Sołek, Przemysław; Kulpa-Greszta, Magdalena; Sowa-Kućma, Magdalena; Koziorowski, Marek

doi:10.1016/j.ygcen.2018.04.007

Cited by 12 publications

(10 citation statements)

References 47 publications

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“…Diminishing expression of the VEGF in the spring may serve in the thermoregulation that required for spermatogenesis. VEGFA have a significant role in the regulation of vascular permeability as well as in spermiogenesis and the proliferation of spermatogonia 81,82 .…”

Section: Discussionmentioning

confidence: 99%

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Abdel-Maksoud

Abd‐Elhafeez

Soliman

2019

Sci Rep

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Telocytes (TCs) are a distinct stromal cell type described in many organs. The present study investigated the existence of TCs within the efferent ductules in camel and the changes that occur in their morphology and activity during active and inactive reproductive seasons. TCs in the camel had a cell body and multiple telopodes (TPs), and most TCs had indented nuclei that exhibited prominent intranucleolar chromatin. TCs exhibited seasonal differences which were evaluated by histochemistry, immunohistochemistry (IHC), Transimition electron microscopy (TEM) and scanning electron microscopy (SEM). The presence of TCs in camel efferent ductules has been confirmed by CD34 positive immunostaing. In addition to the expression of the vascular endothelial growth factor (VEGF) which was stronger in the summer season. TCs exhibited stronger immunoreactivity for progesterone and oestrogen alpha receptors (ESR1) in the spring than in the summer. In addition, TCs showed strong positive immunostaining for both vimentin and androgen receptor (AR). Several ultrastructural changes were observed in TCs during the two seasons. TPs in the summer season had delicate ramifications whereas, in the spring, TPs displayed fine arborization and became more corrugated. TCs acquired signs of exaggerated secretory activities in the spring; TPs became expanded and packed with secretory vesicles. Thus, we conclude that, hormonal alterations during the reproductive cycle impact the morphology and secretory behavior of TCs.

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Section: Discussionmentioning

confidence: 99%

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Abdel-Maksoud

Abd‐Elhafeez

Soliman

2019

Sci Rep

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“…In roe deer testes, the highest levels of VEGF mRNA expression were observed during the pre-rut period, with subsequent reduction [23,24]. Testicular variation of VEGF expression were also reported in other seasonal species such as the white-footed mice [25] and the European bison [25]. Regardless of the timing of angiogenesis, the first step before growth factors recruitment and epithelial cells proliferation is the degradation of the epithelial layer of the existing vessel operated by the matrix metalloproteinases (MMPs) [26].…”

Section: Introductionmentioning

confidence: 55%

“…The vascular endothelial growth factor (VEGF) and its receptors are expressed in all testicular cells, both germ line and interstitial components [21], and play a pivotal role in male germ cell differentiation, proliferation, and migration [43,44]. The function of the VEGF/tyrosine receptor interaction within testicular physiology was studied in numerous species [20,25,45,46], including the roe deer [13]. The results of the present study did not show any statistical difference between pre-and post-rut periods in the gene expression of VEGF (isoforms 121 and 165) and its receptors (R1 and R2), confirming what was already reported by literature [23,24].…”

Section: Discussionmentioning

confidence: 99%

Uncovering the Physiological Mechanisms Underlying the Roe Deer (Capreolus capreolus) Testicular Cycle: Analyses of Gelatinases and VEGF Patterns and Correlation with Testes Weight and Testosterone

Elmi

Zannoni

Govoni

et al. 2020

Animals

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The roe deer (Capreolus capreolus) represents a spontaneous model of testicular inactivation: During winter, bucks show a suspension of spermatogenesis that starts again in spring and peaks during the breeding season (July–August). The underlying mechanisms to the regulation of the cyclic testicular changes are still not fully clear but seem to be imputable to the spermatogenic cell line since other testicular cell populations remain stable without apoptotic phenomena. The aim of the study was to investigate apoptosis, gelatinases (MMP2 and 9), their inhibiting factors (TIMP 1-2), and two isoforms of vascular endothelial growth factor (VEGF121 and 165) with its receptors (VEGFR1-2) in testes collected during pre- and post-rut periods, and to correlate them with testicular weight (TW) and testosterone (TEST). Testes from 18 adult sexually mature bucks were collected in Bologna Apennines (Italy). Samples were weighed and parenchyma collected. Radioimmunoassay, real-time PCR, and zymography were performed. The results showed a post-rut decrease in TW and TEST and an increase in proMMP2, also highlighting a correlation between the gelatinases and the testicular functionality. The VEGF pattern did not show modifications nor correlation with TW and TEST. Overall, gelatinases and their inhibitors, described herein for the first time in roe deer testes, seem to play an important role in the testicular cycle.

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“…In patients with testicular tumor or infertility, abnormal activity of signaling pathways was observed, including the Wnt signaling pathway, the PI3k/Akt signaling pathway, etc 56,[132][133][134][135][136][137] . We had discussed of the TGF-β/Smad, AMPK, and MAPK signaling pathways in SCs to regulate normal spermatogenesis.…”

Section: Pathways and Potential Clinical Applications Of Abnormal Spementioning

confidence: 99%

Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

2019

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The functions of Sertoli cells in spermatogenesis have attracted much more attention recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on nutrient supply, maintenance of cell junctions, and support for germ cells’ mitosis and meiosis. Accumulating evidence in the past decade has highlighted the dominant functions of the MAPK, AMPK, and TGF-β/Smad signaling pathways during spermatogenesis. Among these pathways, the MAPK signaling pathway regulates dynamics of tight junctions and adherens junctions, proliferation and meiosis of germ cells, proliferation and lactate production of Sertoli cells; the AMPK and the TGF-β/Smad signaling pathways both affect dynamics of tight junctions and adherens junctions, as well as the proliferation of Sertoli cells. The AMPK signaling pathway also regulates lactate supply. These signaling pathways combine to form a complex regulatory network for spermatogenesis. In testicular tumors or infertile patients, the activities of these signaling pathways in Sertoli cells are abnormal. Clarifying the mechanisms of signaling pathways in Sertoli cells on spermatogenesis provides new insights into the physiological functions of Sertoli cells in male reproduction, and also serves as a pre-requisite to identify potential therapeutic targets in abnormal spermatogenesis including testicular tumor and male infertility.

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Vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF-2) as potential regulators of seasonal reproductive processes in male European bison (Bison bonasus, Linnaeus 1758)

Cited by 12 publications

References 47 publications

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle

Uncovering the Physiological Mechanisms Underlying the Roe Deer (Capreolus capreolus) Testicular Cycle: Analyses of Gelatinases and VEGF Patterns and Correlation with Testes Weight and Testosterone

Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

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