Vascular Endothelial Growth Factor (VEGF): An Important Marker of Cure Progression in Schistosomiasis Mansoni Disease

Abstract

Background: Schistosomiasis is a major health problem infecting about 7.2 million in Egypt. Praziquantel (PZQ) is the only drug effective against Schistosoma mansoni infection without effective available alternatives. VEGF was used to assess the associated schistosomal inflammatory and hepatic histopathological changes. Aim of Study:The aim of this work is to evaluate the expression of VEGF in hepatocytes and sinusoids of experimental infected mice with Schistosomiasis mansoni comparative to treated group with PZQ.