Vascular endothelial growth factor signalling in endothelial cell survival: A role for NFκB

Grosjean, Jérôme; Kiriakidis, Serafim; Reilly, Kerri; Feldmann, Marc; Paleolog, Ewa

doi:10.1016/j.bbrc.2005.12.095

Cited by 72 publications

(52 citation statements)

References 54 publications

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“…IL-1 activates NFB through the PI3K/AKT/mTOR pathway (32), and osteoclast survival occurs through a TGF-␤ induced TAK1/MEK-mediated AKT activation and NFB signaling cascade (33,34). Vascular endothelial growth factor also has been shown to activate PI3K (35), elevate Bcl-2 expression (35,36), and to enhance NFB mediated survival (37). It will be important to determine whether these other prosurvival signal transduction pathways converge on Bit-1 as Bit-1 may act as a key molecular switch at the nexus of cellular life and death.…”

Section: Discussionmentioning

confidence: 99%

Bit-1 Mediates Integrin-dependent Cell Survival through Activation of the NFκB Pathway

Griffiths¹,

Grundl²,

Leychenko³

et al. 2011

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Bit-1 Mediates Integrin-dependent Cell Survival through Activation of the NFκB Pathway

Griffiths¹,

Grundl²,

Leychenko³

et al. 2011

Journal of Biological Chemistry

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“…bFGF can activate EPCs and then initiates neovascularization (Hebda et al 1990). VEGF plays an important role in regulating the proliferation of endothelial cells and inhibiting apoptosis exerted by VEGF activating anti-apoptotic kinase and maintaining survival signals (Grosjean et al 2006;Liu et al 2002). VEGF also could recruit stem cells from surrounding tissue and bone marrow to the ischemic tissue (Wu et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Adipose Stromal Cells Promotes Neovascularization of Random Skin Flaps

Sheng

Yang

et al. 2011

Tohoku J. Exp. Med.

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The delivery of bone marrow-derived mononulear cells (BM-MNCs) has been proved to be effective at promoting neovascularization of ischemic skin flaps. However, the limited source of BM-MNCs restricts their clinical application. Stromal vascular fraction (SVF) contains a group of heterogeneous cells in the adipose tissue, including adipose tissue-derived stem cells, and it has abundant reserve in human body. In this study, we evaluated the therapeutic potential of SVF to promote neovascularization of random skin flaps. Female Wistar rats were randomly devided into three groups with 8 in each group and received allogeneic SVF, BM-MNCs and phosphate-buffered saline (PBS), respectively, before surgery. Two days after cell administration, a 10 × 3 cm random skin flap was elevated. Flap survival, blood flow perfusion and capillary density were examined 7 days after surgery, and the relevant mechanism was also explored. Results showed that SVF group and BM-MNCs group had higher survival percentage (72.2 ± 2.0% and 76.4 ± 3.1%, respectively) as compared with the control group (56.8 ± 4.6%, P < 0.05). Blood flow perfusion and capillary density of flap tissues in SVF and BM-MNCs groups were both improved. The expression levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were increased in flap tissues of SVF and BM-MNCs groups detected by ELISA. These results indicate that SVF could promote vascularization and increase flap survival probably by secreting VEGF and bFGF. The effect of transplantation of SVF on therapeutic angiogenesis of skin flaps is equivalent to that of BM-MNCs.

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“…Protective factors have been described as well: In sickle cell disease endothelial apoptosis is impaired by VEGF. This has also been shown in vitro, where VEGF inhibits apoptosis of unanchored culture cells 43 . Release of proteases by granulocytes is another well-documented cause of endothelial cell detachment 44-45 46 47 .…”

Section: Phenotype and Mechanisms Of Detachment Of Cec In Vasculitismentioning

confidence: 62%

Markers of Vascular Damage and Repair

Erdbruegger¹,

Dhaygude²,

Woywodt³

2011

Advances in the Etiology, Pathogenesis and Pathology of Vasculitis

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Vascular endothelial growth factor signalling in endothelial cell survival: A role for NFκB

Cited by 72 publications

References 54 publications

Bit-1 Mediates Integrin-dependent Cell Survival through Activation of the NFκB Pathway

Bit-1 Mediates Integrin-dependent Cell Survival through Activation of the NFκB Pathway

Transplantation of Adipose Stromal Cells Promotes Neovascularization of Random Skin Flaps

Markers of Vascular Damage and Repair

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