Abstract:Genetically engineered fusion polypeptides
have been
investigated
to introduce unique bio-functionality and improve some therapeutic
activity for anti-angiogenesis. We report herein that stimuli-responsive,
vascular endothelial growth factor receptor 1 (VEGFR1) targeting fusion
polypeptides composed of a VEGFR1 (fms-like tyrosine kinase-1 (Flt1))
antagonist, an anti-Flt1 peptide, and a thermally responsive elastin-based
polypeptide (EBP) were rationally designed at the genetic level, biosynthesized,
and purifi… Show more
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