Vascular endothelial growth factor protein levels and gene expression in peripheral monocytes after stenting: a randomized comparative study of sirolimus: eluting and bare metal stents

Kochiadakis, George E.; Marketou, Maria; Panutsopulos, D.; Arfanakis, Dimitris; Skalidis, Emmanuel I.; Igoumenidis, Nikolaos E.; Hamilos, Michael I.; Sourvinos, George; Chlouverakis, Gregory; Spandidos, Demetrios Α.; Vardas, Panos

doi:10.1093/eurheartj/ehn060

Cited by 8 publications

(5 citation statements)

References 18 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, drug eluting stent apposition produced a negative effect in the VEGF average changes after PCI evidencing a delay to reach control values to 1-year, which was not observed for bare metal stents. Decreases in VEGF levels were also reported on non-ACS patients treated either with statins [22] or with sirolimus eluting stent 1-month after apposition, but not in patients with bare metal stents [19]. By treating stenosis the ischemic trigger of angiogenesis is reduced [25] and this might be explained by the increase of VEGF levels [26].…”

Section: Discussionmentioning

confidence: 96%

“…These studies have also evidenced the importance of the time gap of patient's evaluation on VEGF assessment. To our knowledge few studies have examined VEGF levels in CAD patients longitudinally after PCI [17–19]. None of previous studies reported on changes over 1-year period after stent apposition.…”

Section: Discussionmentioning

confidence: 99%

“…Published data is scarce and only describes short-term changes of VEGF circulating levels after percutaneous coronary intervention (PCI) [17–19] or bypass surgery [13, 20] in small number of patients. Recently, emerging evidence suggests VEGF may have a protective net effect in the vasculature, giving rise to well-developed coronary collateral arteries in patients with CAD after revascularization intervention [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

et al. 2014

View full text Add to dashboard Cite

We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0–264 pg/mL versus 419, 212–758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167–498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173–497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Rapamycin reduces VEGF expression in both tumor and normal cells [12,14,27,28]. Therefore, we measured VEGF levels in RPE-cells treated with rapamycin.…”

Section: Vegf-expression In Rpe Cells Treated With Rapamycinmentioning

confidence: 99%

Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE‐induced sprouting angiogenesis in vitro

et al. 2008

View full text Add to dashboard Cite

Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments.

show abstract

“…Given that the present study focused on patients clinically presented with CCS and DES implantation, we hypothesized that the differences in study population, implanted stents and duration of follow-up might account for the inconsistent findings. Moreover, experimental data has suggested different modes of monocyte trafficking between acute and chronic inflammation and the inflammatory response of monocytes varies in relation to type of stents ( 31 , 32 ). Therefore, the present study might provide preliminary evidence for the associations between HDL-related inflammatory indices and the risk of ISR in patients with CCS undergoing DES stenting.…”

Section: Discussionmentioning

confidence: 99%

Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention

Guo,

Shen,

et al. 2023

Exp Ther Med

View full text Add to dashboard Cite

Inflammation and disorders in lipid metabolism play pivotal roles in the development and progression of in-stent restenosis (ISR). The present study aimed to investigate the association between the high-density lipoprotein (HDL)-related inflammatory indices and the risk of developing ISR among patients undergoing elective percutaneous coronary intervention (PCI). A sum of 1,471 patients undergoing elective PCI were retrospectively included and classified by tertiles of HDL-related inflammatory indices. The study endpoint was ISR. The multivariable Cox proportional hazards regression analysis with restricted cubic splines (RCS) was used to assess the associations. During a median follow-up of 62.27 months, 251 (17.06%) patients experienced ISR. The incidence of ISR increased with the increasing white blood cell-to-HDL ratio (WHR) tertiles (log-rank test, overall P=0.0082). After full adjustment, the highest tertile of WHR was significantly associated with a 1.603-fold risk of ISR (hazard ratio, 1.603; 95% confidence interval, 1.152-2.231; P=0.005) in contrast to the lowest tertile of the WHR. Results of RCS further indicated that the association between WHR and ISR was in a non-linear and dose-dependent manner (non-linear P=0.034; P overall=0.019). The lymphocyte-to-HDL ratio (LHR) and neutrophil-to-HDL ratio (NHR) were also significantly and positively associated with the risk of ISR, of which the third tertiles were at increased risk of 41.2 and 44.7% after full adjustment, respectively. Overall, lipid metabolism disorders and inflammation were interconnected in the development of ISR; therefore, HDL-related inflammatory indices, including WHR, LHR and NHR, might be potential predictors in the prognosis of elective PCI.

show abstract

Vascular endothelial growth factor protein levels and gene expression in peripheral monocytes after stenting: a randomized comparative study of sirolimus: eluting and bare metal stents

Abstract: SES, in comparison with BMS, results in lower VEGF protein levels and gene expression in peripheral monocytes. The latter shows a positive relationship with in-stent late-luminal loss, suggesting an essential role in the reduced in-stent restenosis seen in SES.

Cited by 8 publications

References 18 publications

Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE‐induced sprouting angiogenesis in vitro

Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention

Contact Info

Product

Resources

About