Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons Against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism

Svensson, Birte; Peters, Marvin; K??nig, Hans-Georg; Poppe, Monika; Levkau, Bodo; Rothermundt, Matthias; Arolt, Volker; K??gel, Donat; Prehn, Jochen H M

doi:10.1097/00004647-200210000-00003

Cited by 74 publications

(75 citation statements)

References 28 publications

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“…VEGF-A also protects stressed neurons in culture, for example after serum withdrawal (Jin et al, 2000a), hypoxia (e.g. Jin et al, 2000b;Svensson et al, 2002), mechanical trauma , chemical toxicity (Cui et al, 2011), or excitotoxicity caused by glutamate or the glutamate mimetic AMPA (Bogaert et al, 2010;Matsuzaki et al, 2001;Svensson et al, 2002). As these culture models did not contain blood vessels, it was concluded that the neuronal survival effects of VEGF-A were vessel independent.…”

Section: Vegf-a As a Survival Factor For Developing And Adult Neuronsmentioning

confidence: 99%

Diverse roles for VEGF-A in the nervous system

2012

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Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of neuronal functions, both in vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance. Recent studies have employed mouse models to distinguish the direct effects of VEGF on neurons from its indirect, vessel-mediated effects. Ultimately, refining our knowledge of VEGF signalling pathways in neurons should help us to understand how the current use of therapeutics targeting the VEGF pathway in cancer and eye disease might be expanded to promote neuronal health and nerve repair.

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Section: Vegf-a As a Survival Factor For Developing And Adult Neuronsmentioning

confidence: 99%

Diverse roles for VEGF-A in the nervous system

2012

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“…VEGF enhances neuronal proliferation (Jin et al, 2002;Zhu et al, 2003), neurite outgrowth and maturation (Rosenstein et al, 2003;Khaibullina et al, 2004), and neuronal survival (Jin et al, 2000(Jin et al, , 2001Svensson et al, 2002). A neuroprotective role for VEGF is supported by the demonstration that VEGF reduces excitotoxic damage to cultured hippocampal neurons (Jin et al, 2000;Matsuzaki et al, 2001;Svensson et al, 2002) and reduces damage in vivo after ischemia (Hayashi et al, 1998;Sun et al, 2003) (but see van Bruggen et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures

McCloskey¹,

Croll²,

Scharfman³

2005

J. Neurosci.

115

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In addition to its potent effects on vasculature, it has become clear that vascular endothelial growth factor (VEGF) has effects on both neurons and glia, and recent studies suggest that it can be neuroprotective. To determine potential mechanisms underlying this neuroprotection, recombinant human VEGF was bath applied to adult rat hippocampal slices, and both extracellular and intracellular recordings were used to examine intrinsic properties and synaptic responses of hippocampal principal neurons. Initial studies in area CA1 showed that VEGF significantly reduced the amplitude of responses elicited by Schaffer collateral stimulation, without influencing membrane properties. Similar effects occurred in CA3 pyramidal cells and dentate gyrus granule cells when their major glutamatergic afferents were stimulated. Because VEGF expression is increased after seizures, effects of VEGF were also examined in rats with recurrent spontaneous seizures. VEGF reduced spontaneous discharges in slices from these rats but had surprisingly little effect on epileptiform discharges produced by disinhibition of slices from control rats. These results demonstrate a previously unknown effect of VEGF on neuronal activity and also demonstrate a remarkable potency in the epileptic brain. Based on this, we suggest that VEGF or VEGF-related targets could provide useful endpoints to direct novel therapeutic strategies for epilepsy.

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“…A modern area of research dealing with VEGF as a means of vascular protection and regeneration aims at neuroprotection; VEGF has been reported to protect motor neurons in vitro from hypoxia-induced toxicity, reactive oxygen and other degrading factors 19 . In addition, VEGF seems to be able to stimulate growth and development of neuronal stem cells as well as to recruit neuronal progenitor cells 20 .…”

Section: Discussionmentioning

confidence: 99%

Angiogenesis: the fundament of osseous regeneration

Jung¹,

Kleinheinz²

2013

Hard Tissue

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IntroductionBone formation, osseous regeneration and the associated physiological and pathologically altered angiogenesis are not only of vital importance in fracture repair but also play a constantly growing role in the diagnosis and treatment of chronically infected bone or osteonecrosis. The jaw and especially the mandible with its exceptional vascularization in the human body are prone to these diseases. The understanding of the molecular mechanisms of osteogenicangiogenic coupling is the fundament of a sufficient diagnosis and therapy. The aim of this critical review is to discuss angiogenesis from the description of the angiogenic cascade with its regulative mechanisms to the demands of regenerative medicine. We follow the process of bone formation under the influence of a sufficient angiogenesis with special regard to the key protagonist vascular endothelial growth factor, the osteogenic-angiogenic interface and their interaction. ConclusionThe potential of angiogenesis as a pivotal factor in many areas of tissue maintenance and regeneration is obvious, and angiogenesis will play a significant role in developing therapeutic regenerative concepts.

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Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons Against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism

Cited by 74 publications

References 28 publications

Diverse roles for VEGF-A in the nervous system

Diverse roles for VEGF-A in the nervous system

Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures

Angiogenesis: the fundament of osseous regeneration

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