Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival

Abstract

The present study suggests that VEGF polymorphisms may contribute to gastric tumor characteristics; these observations, however, requiring further confirmation in a larger multi-ethnic study.

Role of +405C>G and +936C>T Polymorphisms of the Vascular Endothelial Growth Factor Gene and Risk of Esophageal Cancer in the Kashmiri Population

“…The +405G allele has been shown to increase transcriptional activity and lipopolysacharide stimulated VEGF production in peripheral blood mononuclear cells (Watson et al, 2000); (Stevens et al, 2003). Contrary to our findings, association of CC genotype has been reported with increased risk for gastric cancer (Tzanakis et al, 2006), pancreatic adenocarcinoma (Talar-Wojnarowska et al, 2010)and breast cancer (Oliveira et al, 2011). Combined +405 CC+CG genotype has been associated with higher susceptibility for Prostate, gastric (Sfar et al, 2006;Guan et al, 2009), and small cell lung carcinoma in males (Zhai et al, 2008).…”

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

“…Renal cell carcinoma patients carrying the A allele presented less lymph node metastases and a better survival rate than patients with the C/C genotype [33]. Conversely to positive reports, VEGF -2578 C/A was not associated to risk of gastric cancer or cutaneous malignant melanoma [34,35]. In addition to differences in ethnic background between populations, the contrasting reports (including ours) might indicate that the involvement of VEGF -2578 C/A polymorphism in carcinogenesis may vary according to the kind of tumor and disease progression.…”

The Role of Vascular Endothelial Growth Factor Genetic Variability in Cancer

“…These studies include those that evaluate cancer risk and prognosis (25,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), retinopathy (20,(37)(38)(39)(40)(41)(42), nephropathy (43)(44)(45)(46), pre-eclampsia (47,48), and vasculopathy (49-51), among many others. Many of these studies show an increased association of disease and/or inferior outcomes in the subgroup with genotype that would predict a higher VEGF expression.…”