Vascular endothelial growth factor polymorphisms (−460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression

Cosín, R.; Gilabert-Estellés, Juan; Ramón, Luis A.; España, Francisco; Gilabert, J.; Romeu, A.; Estellés, Amparo

doi:10.1016/j.fertnstert.2008.08.079

Cited by 44 publications

(60 citation statements)

References 27 publications

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“…Bhanoori et al (44) demonstrated that the -460T/+405C haplotype of VEGF was less frequently identified in females with endometriosis compared to the controls, and VEGF -460 T/T homozygotes and the T allele are associated with a higher risk of endometriosis in Chinese females. There are also studies that demonstrate the association of the VEGF +936 C/T polymorphism in Caucasian and Japanese females with endometriosis (45,46). In addition, several meta-analyses have demonstrated that the VEGF +936 C/T SNP can predispose to endometriosis (47)(48)(49).…”

Section: Discussionmentioning

confidence: 99%

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

et al. 2014

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Abstract. There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) -460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single-nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high-resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis-related infertility and a control group. None of the three VEGF SNPs were associated with endometriosis-related infertility in the dominant and recessive models. The lowest P-values of the trend were observed for the VEGF +936 C/T (rs3025039) SNP in endometriosis-related infertility (P trend =0.149). Similarly, haplotype analyses of VEGF SNPs did not demonstrate any SNP combination as a risk for endometriosis-related infertility, and the lowest overall P-values, P=0.141 and P corr =0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution of

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Section: Discussionmentioning

confidence: 99%

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

et al. 2014

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“…According to the inclusion criteria, 14 studies were included (Hsieh et al, 2004;Bhanoori et al, 2005;Kim et al, 2005;Ikuhashi et al, 2007;Gentilini et al, 2008;Kim et al, 2008;Zhao et al, 2008;Cosin et al, 2009;Kang et al, 2009;Liu et al, 2009a,b;Attar et al, 2010;Lamp et al, 2010;Altinkaya et al, 2011). The flow chart of study selection is shown in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies

Wang²,

Li³

et al. 2013

Genet. Mol. Res.

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“…In recent years, several published articles indicated that the vascular endothelial growth factor (VEGF) is one of the most important candidate genes for the development of endometriosis, and genetic polymorphisms in VEGF gene might be potentially associated with the risk of endometriosis. [3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20] The þ405G>C genetic polymorphism in 5 0 -untranslated region of VEGF gene (rs2010963), one of the most studied genetic variants resulting from G to C mutations, has been reported to affect on the regulation of VEGF gene expression and contributed to the risk of endometriosis in diverse populations. [3][4][5][6][7][9][10][11][12][13][14][15][16][17] However, findings from these published articles were conflicting but not conclusive.…”

Section: Introductionmentioning

confidence: 99%

The association between vascular endothelial growth factor (VEGF) +405G>C genetic polymorphism and endometriosis

Fang

Gong

Wang

2015

Exp Biol Med (Maywood)

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The vascular endothelial growth factor (VEGF) is one of the most important candidate genes for the development of endometriosis, and VEGF genetic polymorphisms might be potentially associated with endometriosis risk. However, the results still remain controversial. The objective of this study aimed to perform a comprehensive meta-analysis to explore a better understanding of the effects of VEGF þ405G>C genetic polymorphism on the risk of endometriosis. A total of eleven eligible studies were eventually identified in this meta-analysis, including 2829 endometriosis cases and 2947 controls. In the overall analysis, no significant association between the VEGF þ405G>C genetic polymorphism and the risk of endometriosis was detected in all genetic models ( In the subgroup analysis by ethnicities, there was no significant association between VEGF þ405G>C genetic polymorphism and endometriosis risk in Asians and/or Caucasians under all genetic models (all P-values >0.05). No publication bias was observed in this study. This meta-analysis supports that the VEGF þ405G>C genetic polymorphism is not significant associated with the risk of endometriosis.

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Vascular endothelial growth factor polymorphisms (−460C/T, +405G/C, and 936C/T) and endometriosis: their influence on vascular endothelial growth factor expression

Cited by 44 publications

References 27 publications

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies

The association between vascular endothelial growth factor (VEGF) +405G>C genetic polymorphism and endometriosis

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