Vascular endothelial growth factor in thyroid cyst fluids

Abstract

Significantly increased VEGF concentrations were found in bloody cyst fluid and in cyst fluid of thyroid adenomatous goiter, compared with VEGF concentrations in degenerative thyroid cysts. Our results suggest that VEGF may play an important role in the pathogenesis of thyroid cyst fluid.

Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts

“…The epithelial expression of VEGF in RCs and RRCs might constitute an additional mechanism for the enlargement of these lesions, maintaining the stimulus for angiogenesis and vascular permeability, a role also proposed by Leonardi et al 18 Results from studies of the expression of VEGF in brain tumor cysts 13,15,17 and cyst fluid of thyroid nodules 14,16 also corroborate this suggestion. According to Vaquero et al, 15 VEGF might enhance accumulation of cyst fluid, together with an increase in oxygen supply boosting the development of the cyst.…”

“…6,18 Therefore, VEGF has been implicated as an important factor in granulation tissue development 7,8,11,12 and cyst enlargement. [13][14][15][16][17] In the present study, we evaluated the expression of VEGF in PGs, RCs, and RRCs. The results revealed that VEGF is expressed in the connective tissue of all of these lesions and in the epithelial lining of RCs and RRCs, corroborating earlier studies.…”

“…It has been speculated that the presence of VEGF in cystic lesions is capable of increasing vascular permeability, leading to accumulation of cystic fluid. [13][14][15][16][17] Leonardi et al 18 proposed a similar function for VEGF in periapical lesions. According to those authors, the expression of VEGF in PGs and RCs has bioactivity to increase vascular permeability, being at a Doctoral student.…”

Correlation of vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in serum and thyroid nodules with histopathological and radiological variables

“…Positive correlations between VEGF in cyst fluid and the recurrence and growth of cystic thyroid nodules have been reported. [161718] These studies showed a correlation between the VEGF concentration and thyroid volume but did not find a correlation between VEGF and cyst volume. In our study, we did not find any correlation between nodule size and sVEGF, nVEGF, sVEGFR-1, or nVEGFR-1 levels.…”

“…VEGF is a glycoprotein; it is 34–42 kDa by weight, and its expression has been shown in various cancer cells. [789131415161718]…”