Vascular endothelial growth factor in minor salivary glands: effect of ageing

Oliveira, Laser Antônio Machado; Vasconcelos, F de Oliveira; Gomez, Ricardo Santiago

doi:10.1046/j.1365-2842.2002.00800.x

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…VEGF is primarily produced by the parotid glands in humans, but is also produced by the submandibular glands in rats [ 11 ]. The expression level of VEGF in salivary glands does not change dramatically with age [ 38 ]. The expression level of VEGF in salivary glands is sufficiently high to induce angiogenesis in salivary glands in an autocrine manner [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model

Yoon

Kim

Lee³

et al. 2022

Head Face Med

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Background 4-Hexylresorcinol (4HR) is a food additive and class I histone deacetylase inhibitor. In this study, we examined the effects of 4HR administration on the submandibular gland in a growing rat model. Methods Four-week-old rats were used in this study. The experimental group (nine males and eight females) received 12.8 mg/kg of 4HR weekly for 12 weeks. Ten rats (five males and five females) were used as controls. The submandibular glands of rats were collected 12 weeks after the first administration of 4HR. The weight of the glands was measured. Histological analysis, immunoprecipitation-high-performance liquid chromatography (IP-HPLC), and western blotting were performed. Results The weights of the rat submandibular glands were higher in the experimental groups than in the control group, especially in male rats (P < 0.05). The vascular endothelial growth factor (VEGF) and testosterone in the submandibular glands were more highly expressed in 4HR-treated male rats than in untreated rats, as detected by both western blotting and immunohistochemistry. The IP-HPLC results demonstrated that the expression levels of Ki67, epidermal growth factor, and testosterone in the submandibular glands were higher in 4HR-treated male rats than in untreated rats. Conclusions This study demonstrated that the systemic administration of 4HR increased the weight of submandibular glands in male rats. In addition, the testosterone and VEGF expression levels in the submandibular glands increased owing to 4HR administration.

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Section: Discussionmentioning

confidence: 99%

Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model

Yoon

Kim

Lee³

et al. 2022

Head Face Med

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“…We hypothesize that this could explain the reduced capacity to produce VEGF in the physiological process of tissue ageing. However, a recent study by de Oliveira et al (46) evaluates the effect of ageing on the immune localization of VEGF in minor labial salivary glands. They found no difference between the immune localization of VEGF in the minor salivary glands of young patients compared with elderly ones, and stated that ageing did not alter the immune localization of VEGF in minor salivary glands.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor Expression (VEGF) in Salivary Glands of Young and Old Hyperoxic Rats

Artese¹,

Perrotti

Giulio

et al. 2006

Eur J Inflamm

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The aim of this study is to evaluate whether hyperoxia and age can influence the expression of vascular endothelial growth factor (VEGF) in the salivary glands of rats. Our study was carried out on four groups of male Wistar rats (total 24 rats). One group was composed of 6 young rats (3 months old); another group by 6 old rats (24 months old). The rats belonging to the first two groups were exposed to hyperoxia (98-100% O 2 ) for a period of 60-65 hours in a large Plexiglas chamber; the other two groups were control groups. The rats were then anaesthetized with Nembutal (30 mg/kg) intraperitoneally and then killed. The submandibular glands were removed and processed for immunohistochemical analysis of VEGF. The exposure to hyperoxia decreased salivary gland VEGF expression in rats. The tissues analyzed (nervous tissue, vascular endothelium, myoepithelial cells, ductal endothelium, mucinous glands) always expressed VEGF, thus demonstrating that not only vascular endothelial cells, but also the other elements evaluated, have a role in the neoangiogenesis. Only in the serous glands, in both normoxic and hyperoxic young and old rats, was the VEGF expression constantly negative and it did not influence the neoangiogenesis. The vascular growth is a fundamental part of normal salivary gland development, so we speculated that strategies aimed at preservation or promotion of salivary gland VEGF expression may mitigate or attenuate hyperoxia-induced gland microvascular injury. Further studies specifically aimed at investigating these prospects are warranted.

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“…De Oliveira et al . demonstrated that VEGF was immunohistochemically observed in the basolateral serous acinar cells, striated ducts and intercalated ducts of the salivary glands 11 . Brozovic et al .…”

Section: Introductionmentioning

confidence: 99%

“…10 De Oliveira et al demonstrated that VEGF was immunohistochemically observed in the basolateral serous acinar cells, striated ducts and intercalated ducts of the salivary glands. 11 Brozovic et al reported that salivary VEGF values decreased in the acute stage of aphthous ulcer with a diameter exceeding 10 mm and recover to normal values after cure. 10 This observation suggests that salivary VEGF values are capable of being a candidate marker to evaluate the degree of oropharyngeal mucosal injury.…”

Section: Introductionmentioning

confidence: 99%

Decreased salivary vascular endothelial growth factor in elderly patients with pneumonia during the course of recovery

Miyaji

Ohwada

Iwabuchi

et al. 2006

Geriatrics Gerontology Int

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Background: Elderly individuals are known for their high risk of acquiring pneumonia. Poor oral hygiene and high incidence of gastro-oesophageal reflux continue to cause persistent oropharyngeal mucosal injuries and results in overgrowth of bacterial population and alteration of bacterial flora to respiratory pathogens in the oropharyngeal cavity. Salivary secretion contributes in maintaining homeostasis of the oropharyngeal mucosal barrier. Vascular endothelial growth factor (VEGF) acts as an angiogenic and permeabilityenhancing cytokine but is normally secreted in saliva. It has been previously demonstrated that VEGF secreted in the airway functions in the restoration or repair of the injured tissue. We hypothesized that salivary VEGF is a candidate as a marker to evaluate the degree of oropharyngeal mucosal injury. Methods:We compared the volumes, protein contents, and the amount of VEGF secreted in the saliva of patients with pneumonia during the course of recovery (P; n = 7) and those without pneumonia (n = 10).Results: Volumes and protein contents within the secreted saliva were similar between the patients with P and the control subjects (0.60 ± 0.28 mL versus 0.41 ± 0.34 mL, P = 0.126, 7.12 ± 5.57 µg/mL versus 3.92 ± 3.58 µg/mL, P = 0.231, respectively). The concentrations of salivary VEGF were significantly lower in patients with P than those of the controls (0.71 ± 0.37 versus 2.66 ± 3.44 µg/µg protein, P = 0.032). Conclusion:Lower concentrations of salivary VEGF in patients with pneumonia during the course of recovery suggested the presence of persistent oropharyngeal mucosal injury even after normalization of systemic C-reactive protein levels. The concentration of salivary VEGF is capable of being a marker for discriminating impaired oral mucosal barrier that precipitates in development of pneumonia in elderly individuals.

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Vascular endothelial growth factor in minor salivary glands: effect of ageing

Cited by 5 publications

References 13 publications

Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model

Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model

Vascular Endothelial Growth Factor Expression (VEGF) in Salivary Glands of Young and Old Hyperoxic Rats

Decreased salivary vascular endothelial growth factor in elderly patients with pneumonia during the course of recovery

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