Vascular endothelial growth factor gene 936 C/T polymorphism in breast cancer patients

Prognostic evaluation of VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic breast cancer

“…With regards to rs1570360 or rs3025039, our results indicate no significant associations with breast cancer characteristics, which appear to corroborate previous reports either for rs1570360 23,42 or rs3025039. 23,26,30,42,45 In relation to rs2010963, however, our lack of significant associations with histopathological features of breast cancer contradicts previous studies, which have indicated that patients with the variant CC 23,35,42 or GC genotypes 44 have larger tumor size (> 20 mm),if compared to those with the major GG genotype. Luo et al 35 also found positive association between the variant homozygous CC genotype of rs2010963 and high histological grade, whereas Sa-Nguanraksa et al 44 found positive associations for the GC genotype with perineural invasion and advanced tumor stage (II-IV).…”

“…22,21,12 VEGFA SNPs were shown to affect VEGFA levels in different cell models, 21,[23][24][25] including breast cancer. 26 VEGFA SNPs have also been associated with breast cancer susceptibility, 11,13,23,[26][27][28][29][30][31][32][33][34][35][36][37][38][39] increased risk of progression 13,[40][41][42][43][44] or poor survival. 13,43 However, most of these works focused on the effects of SNPs evaluated separately, and the results from different authors present great disparity.…”

Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis

“…A study which was included in our meta-analysis told us that the mechanism might be due to linkage disequilibrium between ?936TC and another yet unknown functional polymorphism in the VEGF gene sequence [23]. Some researches suggested that VEGF gene ?936 polymorphism might also be the risk factor of other diseases such as glioma, colorectal adenoma, colon cancer, and breast cancer, but the detailed mechanism was not clear either [33][34][35][36][37].…”

Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Breast Cancer Risk in a Chinese Population

“…The associations between three VEGF gene polymorphisms (-634 G/C, +936 C/T, and +1612 G/A) and breast cancer risk have been extensively studied, and the currently available results are inconclusive (Krippl et al, 2003;Jin et al, 2005;Lu et al, 2005;Jacobs et al, 2006;Kataoka et al, 2006;Eroglu et al, 2008;Jakubowska et al, 2008;Langsenlehner et al, 2008;Schneider et al, 2008;Wehrschuetz et al, 2009;Gu and Wang, 2011;Jin et al, 2011;Liu et al, 2011;Oliveira et al, 2011;Qiu et al, 2011;Wang et al, 2011;Yang et al, 2011;Rodrigues et al, 2012). The aim of this study was to investigate the association between three VEGF gene polymorphisms and breast cancer risk in Chinese Han patients.…”