Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma

Klein, Marc; Picard, Émilie; Jm, Vignaud; Marie, Béatrice; Bresler, L.; Toussaint, Bertrand; Weryha, G.; Duprez, A; Leclère, J

doi:10.1677/joe.0.1610041

Cited by 140 publications

(125 citation statements)

References 33 publications

(30 reference statements)

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“…Yet, VEGF overexpression in thyroid tumours appears to be related to some clinical/pathological data of the patients (6 -10). VEGF overexpression correlated with PTC size in adults and children (9), and higher VEGF expression correlated with tumour metastatic behaviour and recurrence (8). In the present report, VEGF staining was found to be significantly more frequent in PTCs than in FTCs or PDTCs.…”

Section: Discussionsupporting

confidence: 64%

“…Recently, VEGFR expression has been reported in various types of tumour, such as leukaemia (3), pancreatic carcinoma (4) and prostatic carcinoma (5), suggesting a potential autocrine/paracrine VEGF action in these tumours. In thyroid carcinomas, VEGFR expression has been reported mainly in endothelial cells (6,8). However, one study (9) indicated that, besides endothelial cells, VEGFR-1 might also be expressed by PTC cells.…”

Section: Discussionmentioning

confidence: 99%

“…For example, VEGF and VEGFR-1 expression correlate with PTC size in children and adults (9), thyroid tumours that have metastasized have higher levels of VEGF than nonmetastatic disease, correlating with a worse prognosis (8), and lymph-node metastases of thyroid carcinomas showed increased VEGF expression compared with primary tumour (7). Whereas VEGF expression is well documented, much less is known about VEGFR expression in thyroid carcinomas, and some studies obtained contradictory results (6,8,9). For instance, some reports describe VEGFR-1 expression as restricted to endothelial cells of normal thyroid tissue, PTCs and FTCs (6,8).…”

Section: Introductionmentioning

confidence: 99%

“…Whereas VEGF expression is well documented, much less is known about VEGFR expression in thyroid carcinomas, and some studies obtained contradictory results (6,8,9). For instance, some reports describe VEGFR-1 expression as restricted to endothelial cells of normal thyroid tissue, PTCs and FTCs (6,8). However, others (9) reported VEGFR-1 expression also in PTC cells, raising the possibility of an autocrine mechanism for VEGF on thyroid follicular cells.…”

Section: Introductionmentioning

confidence: 99%

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Expression of vascular endothelial growth factor (VEGF) and its receptors in thyroid carcinomas of follicular origin: a potential autocrine loop

Vieira¹,

Santos

Espadinha

et al. 2005

eur j endocrinol

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Objective: The aim of this study was to clarify the role of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) pathways in thyroid tumourigenesis. Methods: We examined VEGF, VEGFR-1 and VEGFR-2 expression on 34 papillary thyroid carcinomas (PTCs), 18 follicular thyroid carcinomas (FTCs), eight poorly differentiated thyroid carcinomas (PDTCs) and on a thyroid tumour-derived cell line (NPA 0 87) by immunohistochemistry, reverse transcriptase PCR, immunofluorescence and Western blotting. Results: We have demonstrated that VEGF expression was significantly (P , 0.05) more prevalent in PTCs (79%) than in FTCs (50%) or PDTCs (37%). Similarly, 76% of PTCs, 83% of FTCs and 25% of PDTCs expressed VEGFR-1, whereas 68% of PTCs, 56% of FTCs and 37% of PDTCs expressed VEGFR-2. Coexpression of VEGF and its receptors was observed in 50% of PTCs, 39% of FTCs and 12% of PDTCs, raising the possibility that VEGF may signal in an autocrine loop in these neoplasias, as observed previously for other types of cancer. In agreement with the idea that autocrine VEGF signalling plays an important role in thyroid carcinogenesis, the blockade of either VEGF or its receptors with neutralizing antibodies significantly reduced cell viability and increased apoptosis levels of the VEGFR-positive thyroid tumour cell line NPA 0 87. Conclusions: Our results highlight a previously undefined VEGF autocrine action in thyroid carcinomas which could play a crucial role in tumour cell survival and could represent a useful therapeutic target for thyroid tumours.European Journal of Endocrinology 153 701-709

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of vascular endothelial growth factor (VEGF) and its receptors in thyroid carcinomas of follicular origin: a potential autocrine loop

Vieira¹,

Santos

Espadinha

et al. 2005

eur j endocrinol

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show abstract

“…A common feature of thyroid cancers is their markedly increased vascularization, with an elevated expression of the vascular endothelial growth factor (VEGF) by immunohistochemistry, compared with normal thyroid tissue (Klein et al, 1999;Bauer et al, 2003). VEGF levels are correlated with stage, tumor size, nodal involvement, extra-thyroidal invasion, and distant metastases (Chaplin et al, 1996).…”

Section: Anti-angiogenetic Agentsmentioning

confidence: 99%