Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

Papazoglou, Dimitrios; Γαλάζιος, Γεώργιος; Koukourakis, Michael I.; Panagopoulos, Ioannis; Kontomanolis, Emmanuel N; Παπαθεοδώρου, Κωνσταντίνος; Maltezos, Efstratios

doi:10.1093/molehr/gah048

Cited by 84 publications

(58 citation statements)

References 32 publications

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“…This is the first study that, apart from the correlation of VEGF to the development of heart failure, provides information concerning the frequencies of such a wide range of this gene’s polymorphisms in the healthy Greek population, which are consistent with polymorphism frequencies in other studies [44,45,46]. Specifically, the aforementioned studies have been conducted in the Greek population and the frequencies of the studied polymorphisms (–634, +936) of their control groups (n = 79 [44], n = 73 [45] and n = 82 [46]) agree with the observed frequencies of our sample.…”

Section: Discussionsupporting

confidence: 88%

Association of VEGF Gene Polymorphisms with the Development of Heart Failure in Patients after Myocardial Infarction

Douvaras¹,

Antonatos

Kekou³

et al. 2009

Cardiology

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Objectives: Vascular endothelial growth factor (VEGF) is upregulated in vivoin the ischemic human myocardium. Since several polymorphisms have been shown to influence VEGF expression, we evaluated the contribution of such polymorphisms to the clinical outcome of patients after an acute myocardial infarction (AMI). Methods: PCR and restriction fragment length polymorphism analysis was performed to genotype 10 VEGF polymorphisms in 102 patients who had suffered an AMI and in 98 age- and sex-matched healthy individuals. Distribution of these polymorphisms was assessed by logistic regression analysis. Results: No significant differences were found between patients and normal individuals. However, when patients were subdivided into 2 groups based on the development of heart failure after their AMI judged by heart ultrasound measurements (ejection fraction <40%), the distribution of the –634 polymorphism differed significantly (p = 0.016). Specifically, patients with a CC genotype had 7 times higher risk of developing heart failure. Additionally, the co-inheritance of –634 with other VEGF polymorphisms was found to be significant for the development of heart failure between these 2 groups. Conclusions: Our data indicate that the –634 polymorphism and its co-inheritance with genotypes of other VEGF polymorphisms might be considered as risk factors playing a role in the clinical outcome of AMI patients.

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Section: Discussionsupporting

confidence: 88%

Association of VEGF Gene Polymorphisms with the Development of Heart Failure in Patients after Myocardial Infarction

Douvaras¹,

Antonatos

Kekou³

et al. 2009

Cardiology

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“…All examinations were performed according to the methods described previously. 33 We selected 553 sex-and age (±5 years)-matched control subjects from patients presenting at our hospitals during the same period for health examinations, including biochemical testing, electrocardiogram, and brain MRI. Control subjects did not have a recent history of cerebrovascular disease or myocardial infarction.…”

Section: Study Populationmentioning

confidence: 99%

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

Jeon

Kim

et al. 2013

ATVB

118

104

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Objective— MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a , miR-149 , miR-196a2 , and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. Methods and Results— Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 patients with ischemic stroke, 373 patients with SBI, and 553 control subjects. The miR-146a C>G polymorphism and miR-146a G/ -149 T/ -196a2 C/ -499 G allele combination was significantly associated with ischemic stroke prevalence. For SBI prevalence, there were no statistically significant genetic markers. However, some allele combinations were associated with increased SBI incidence (C-T-C-G and G-T-T-A of miR-146a / -149 / -196a2 / -499 ). In subgroup analyses, miR-146a C>G increased stroke risk in female, normotensive, and nondiabetic groups. There were significant combined effects between microRNA polymorphisms and homocysteine/folate levels on ischemic stroke and SBI prevalence. Conclusion— The miR-146a G allele and miR-146a G/ -149 T/ -196a2 C/ -499 G allele combination were associated with ischemic stroke pathogenesis. The combined effects between microRNA polymorphisms and homocysteine/folate levels may contribute to stroke and SBI prevalence.

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“…All examinations were performed according to the methods described previously. 27,40 We selected 494 control subjects matched for gender and age within 5 years from patients presenting at our hospitals for health examinations, which included biochemistry testing, an electrocardiogram, and brain MRI during the same period and who were free from a recent history of cerebrovascular disease or myocardial infarction. Exclusion criteria were the same as those used in the patient group, as mentioned previously.…”

Section: Study Populationmentioning

confidence: 99%

“…The primers and polymerase chain reaction conditions for VEGF polymorphism analyses have been previously described. 27,28 …”

Section: Genotype Determination Of Vegf Polymorphismsmentioning

confidence: 99%

Association Between VEGF Polymorphisms and Homocysteine Levels in Patients With Ischemic Stroke and Silent Brain Infarction

Hong

Kim

et al. 2011

Stroke

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Background and Purpose-Vascular endothelial growth factor (VEGF) plays a role in atherosclerosis-related diseases such as cerebrovascular or cardiovascular diseases. However, the effect of VEGF -2578CϾA, -1154GϾA, -634GϾC, and 936CϾT polymorphisms on the susceptibility to stroke and silent brain infarction has not been reported. Methods-Using polymerase chain reaction-amplified DNA, VEGF polymorphisms were analyzed in 615 patients with ischemic stroke, 376 patients with silent brain infarction, and 494 control subjects. Results-The AA and CCϩCA (C allele bearing) genotype frequencies of the -2578CϾA polymorphism and the CTϩTT (T allele-bearing) genotype frequency of the 936CϾT polymorphism were significantly different between the stroke and control groups (false discovery rate-adjusted probability values of 0.016, 0.044, and 0.044, respectively). When stratified by the size of the occluded vessel, the VEGF polymorphisms were associated with patients with multiple small-artery occlusions. Several haplotypes of the VEGF polymorphisms were significantly different between the control and stroke groups. With respect to silent brain infarction, the difference in the frequency of the -634GϾC polymorphism between the GCϩCC (C allele-bearing) genotype and the controls was marginally significant (false discovery rate-adjusted probability value of 0.056). On the other hand, the -634GϾC and 936CϾT polymorphisms were associated with plasma homocysteine levels of patients with multiple or single small-artery occlusions, respectively. Conclusions-This study suggests that VEGF polymorphisms and haplotypes are possible genetic determinants for the risk of ischemic stroke, particularly in patients with multiple small-artery occlusions. However, VEGF polymorphisms had only a weak association with plasma homocysteine levels in the Korean population. (Stroke. 2011;42:2393-2402.)

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Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

Cited by 84 publications

References 32 publications

Association of VEGF Gene Polymorphisms with the Development of Heart Failure in Patients after Myocardial Infarction

Association of VEGF Gene Polymorphisms with the Development of Heart Failure in Patients after Myocardial Infarction

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

Association Between VEGF Polymorphisms and Homocysteine Levels in Patients With Ischemic Stroke and Silent Brain Infarction

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