Vascular Endothelial Growth Factor-C and Its Receptor VEGFR-3 in the Nasal Mucosa and in Nasopharyngeal Tumors

Saaristo, Anne; Partanen, Taina A.; Arola, Johanna; Jussila, Lotta; Hytönen, Maija; Mäkitie, Antti; Vento, Seija; Kaipainen, Arja; Malmberg, Henrik; Alitalo, Kari

doi:10.1016/s0002-9440(10)64510-5

Cited by 40 publications

(32 citation statements)

References 29 publications

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“…The vessel specific protein (VEGFR3 or CD34) is then kept upregulated, whereas the respective other protein ceases. This thesis is in line with results published recently in nasal 36 and breast carcinomas, 32 in which VEGFR3 and PAL-E coexpression has been described in tumor vessels in a similar fashion. Double staining of VEGFR3 and VEGFR2 in HNSCC was rare.…”

Section: Vegf-c Expression In Hnsccsupporting

confidence: 92%

Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck

et al. 2003

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Section: Vegf-c Expression In Hnsccsupporting

confidence: 92%

Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck

et al. 2003

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“…It is known that nasal mucosa typically contains large numbers of lymphatic vessels which play a crucial role in different complaints such as inflammatory diseases [19]. In our study, we found numerous lymphatics labeled by D2-40 in the periphery and in the center of SHP.…”

Section: Discussionsupporting

confidence: 61%

D2-40 staining in sinonasal-type hemangiopericytoma—further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor

Hansen

Katenkamp

2005

Virchows Arch

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D2-40 is a monoclonal antibody, which reacts with a fixative-resistant epitope of lymphatic endothelium. Sinonasal-type hemangiopericytoma (SHP) and tumors of the (conventional) hemangiopericytoma/solitary fibrous tumor family (HP/SFT) are characterized by prominent vasculature. However, data concerning D2-40 labeling of these tumors are very sparse. In the present study, we investigated D2-40 staining in tissue specimens of 17 patients with SHP (male to female ratio of 2.4:1, median age of 63 years) and compared the immunolabeling with 20 cases of HP/SFT, including three SFT cases from nasal mucosa. D2-40 was detected in vascular channels of all SHP patients examined. By contrast, all cases of HP/SFT did not reveal any vascular channel being positive for D2-40, neither in the nasal cases nor in the remaining patients. This study presented for the first time data on D2-40 labeling in a series of SHP, HP/SFT, and supports the distinction of SHP from HP/SFT.

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“…VEGFR-3 expression in tumor cells has been reported in patients with malignant mesothelioma, 35,40 Kaposi sarcoma, 41 vascular tumors, 42 nasopharyngeal tumors, 43 and adenocarcinoma of the lung. 44 These reports evaluated VEGFR-3 expression in vascular endothelial cells but not in tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

Arinaga

Noguchi

Takeno

et al. 2003

Cancer

141

103

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A temperature‐sensitive polymer, poly(N‐isopropylacrylamide) [poly(NIPAM)], was tested to flocculate kaolinite clay suspensions. Settling tests at both room temperature and 40°C were carried out. The results show that settling at 40°C resulted in significantly higher settling rates and smaller sediment volumes. This behavior indicates that the polymer molecules changed from a stretched structure to a coil‐like conformation with increasing temperature. It is the change in conformation that induced more compacted flocs, thus resulting in faster settling. To understand the role of temperature in the flocculation, the long‐range interaction and adhesion forces between kaolinite clay particles in the polymer solutions at both room temperature and 40°C were measured using an atomic force microscope (AFM). The measured adhesion forces correlated well with the settling characteristics: a stronger adhesion led to a higher initial settling rate. The retraction force profiles obtained at different temperatures confirmed the conformational change of the polymer with temperature. © 2006 American Institute of Chemical Engineers AIChE J, 2007.

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Vascular Endothelial Growth Factor-C and Its Receptor VEGFR-3 in the Nasal Mucosa and in Nasopharyngeal Tumors

Cited by 40 publications

References 29 publications

Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck

Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck

D2-40 staining in sinonasal-type hemangiopericytoma—further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

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