Vascular endothelial growth factor C/A 2578 gene polymorphism and umbilical artery Doppler in preeclamptic women

Mowad, Hanan H.; Abougabal, Khadiga; Fahim, Ashraf Samir; Shehata, Nesreen A.A.; Ali, Hamada A.A.; Nasser, Mona

doi:10.1016/j.preghy.2019.09.016

Cited by 3 publications

(2 citation statements)

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“…VEGF is a growth and hypoxia‐induced factor involved in the regulation of proliferation, vascular permeability, function, and differentiation of endothelial cells 29 . VEGF signaling can stimulate endothelial no‐synthase (eNOS) and increase the production of potent vasodilator nitric oxide (NO) 30 . Therefore, the expression pattern of VEGF is closely related to the occurrence of PIH.…”

Section: Genetic Polymorphisms Of Pihmentioning

confidence: 99%

“…29 VEGF signaling can stimulate endothelial no-synthase (eNOS) and increase the production of potent vasodilator nitric oxide (NO). 30 Therefore, the expression pattern of VEGF is closely related to the occurrence of PIH. A metaanalysis by Duan et al found that VEGF gene rs3025039 T and rs2010963 C alleles significantly increased the risk of PE in the study population.…”

Section: Genetic Polymorphisms In the Endothelin Systemmentioning

confidence: 99%

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The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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Section: Genetic Polymorphisms Of Pihmentioning

confidence: 99%

Section: Genetic Polymorphisms In the Endothelin Systemmentioning

confidence: 99%