Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Olofsson, Birgitta; Pajusola, Katri; Kaipainen, Arja; Euler, Gabriel von; Joukov, Vladimir; Saksela, Olli; Orpana, Arto; Pettersson, Ralf F.; Alitalo, Kari; Eriksson, Ulf

doi:10.1073/pnas.93.6.2576

Cited by 667 publications

(400 citation statements)

References 31 publications

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“…However, the family of VEGF genes has expanded with the discovery of other VEGFs, for example, VEGF-B (Olofsson et al, 1996a), VEGF-C (Joukov et al, 1996) and VEGF-D (Achen et al, 1998), which share significant sequence homology with VEGF-A. VEGF-B exists as two splice variants, a heparin binding isoform of 167 amino acids ) and a secreted isoform of 186 amino acids (VEGF-B 186 ) (Olofsson et al, 1996b).…”

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confidence: 99%

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Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer

et al. 2003

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confidence: 99%

“…Whereas VEGF-A binds to both the VEGFR-1 and VEGFR-2 receptors, VEGF-B binds only to the VEGFR-1 receptor (flt-1) (Olofsson et al, 1998). Vascular endothelial growth factor-B forms homodimers and can heterodimerise with VEGF-A (Olofsson et al, 1996a) to promote endothelial cell proliferation in vitro (Olofsson et al, 1996a).…”

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confidence: 99%

Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer

et al. 2003

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“…Discovered in 1996, 8 VEGF-B has approximate 47% and 37% amino acids sequence identical with VEGF-A and PlGF. 9 Owing to alternative splicing event, the VEGF-B gene generates two isoforms: VEGF-B 167 and VEGF-B 186 , 42/60 KDa homodimers, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…VEGF-B 167 has a heparin-binding domain, thus upon exudation it binds to cell surface heparin sulfate proteoglycans to anchor this isoform in extracellular matrix. 8 Unlike VEGF-B 167 , VEGF-B 186 does not connect the heparin, hence more diffusible. 11 The ratio of VEGF-B 167 /VEGF-B 186 varies significantly among species.…”

Section: Introductionmentioning

confidence: 99%

“…82 Potentially, the exogenous VEGF-B expression can touch off the endogenous expression of co-expressed mitochondrial genes, given endogenous VEGF-B levels are highest in the heart. 8 The antiapoptotic impact was accounted to the antiapoptotic gene expression profile in cardiomyocytes and the metabolic change. To summarize, the effect of VEGF-B overexpression reflected in three aspects, cardiac growth promoting effect therefore displayed a compensatory hypertrophy; angiogenic effect and its related metabolic effects to modulate metabolism of ECs 82 and cardiomyocytes; 70 the protection of cardiomyocytes; from apoptosis; the manipulation of cardiac stem cell to protect against short- and long-term ischemia-reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor-B: Impact on physiology and pathology

Zhu

Gao

et al. 2017

Cell Adhesion & Migration

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Angiogenesis plays an important role in controlling tissue development and maintaining normal tissue function. Dysregulated angiogenesis is implicated in the pathogenesis of a variety of diseases, particularly diabetes, cancers, and neurodegenerative disorders. As the major regulator of angiogenesis, the vascular endothelial growth factor (VEGF) family is composed of a group of crucial members including VEGF-B. While the physiological roles of VEGF-B remain debatable, increasing evidence suggests that this protein is able to protect certain type of cells from apoptosis under pathological conditions. More importantly, recent studies reveal that VEGF-B is involved in lipid transport and energy metabolism, implicating this protein in obesity, diabetes and related metabolic complications. This article summarizes the current knowledge and understanding of VEGF-B in physiology and pathology, and shed light on the therapeutic potential of this crucial protein.

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Expression and localization of placenta growth factor and PlGF receptors in human meningiomas

Donnini¹,

Machein

Plate

et al. 1999

J. Pathol.

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It has previously been suggested that in human brain tumours, endothelial cell proliferation during angiogenesis is regulated by a paracrine mechanism involving vascular endothelial growth factor (VEGF) and its receptors (VEGF receptor 1 and VEGF receptor 2). The mechanism of growth factor up‐regulation is based on hypoxic activation of mRNA expression and mRNA stabilization and genetic events, leading to an increase of growth factor gene expression. The role of the other newly discovered VEGF family members with a high specificity for endothelial cells in the pathogenesis of glial neoplasms is unknown. To investigate which other members of the VEGF family are overexpressed in human brain tumours, the mRNA levels of placenta growth factor (PlGF), VEGF‐A, and VEGF‐B genes were determined by northern blot analysis in surgically obtained human meningiomas. In the 16 meningiomas examined, the mRNA for PlGF was highly expressed in four tumours and VEGF‐A mRNA was highly abundant in three tumour samples. There was no close correlation between PlGF mRNA levels and VEGF‐A expression levels. VEGF‐B mRNA was abundantly expressed in all tumour samples at uniform levels. In a PlGF‐positive tumour sample, immunoreactive VEGFR‐1 and VEGFR‐2 were detected in endothelial cells of the blood vessels. PlGF protein was detectable in most but not all capillaries of the tumour. PlGF is thus highly up‐regulated in a subset of human meningiomas and may therefore have functions, in some tumour vessels, connected to endothelial cell maturation and tube formation. These findings suggest that PlGF, in addition to VEGF‐A, may be another positive factor in tumour angiogenesis in human meningiomas. Copyright © 1999 John Wiley & Sons, Ltd.

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Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Abstract: We have isolated and characterized a novel growth factor for endothelial cells,

Cited by 667 publications

References 31 publications

Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer

Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer

Vascular endothelial growth factor-B: Impact on physiology and pathology

Expression and localization of placenta growth factor and PlGF receptors in human meningiomas

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