Vascular endothelial growth factor and inhibin A in follicular fluid of infertile patients who underwent in vitro fertilization with a gonadotropin-releasing hormone antagonist

Cunha-Filho, João Sabino; Lemos, Nadiane Albuquerque; Stein, Nina Rodrigues; Laranjeira, Andréia Ferreira; Passos, Eduardo Pandolfi

doi:10.1016/j.fertnstert.2004.11.027

Cited by 17 publications

(19 citation statements)

References 28 publications

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“…Recently, we demonstrate there were no differences in inhibin A and VEGF in the follicular fluid of patients submitted to IVF with GnRH antagonist, comparing with natural cycles [15]. These results confirm the safety and effectiveness of the medication.…”

Section: Discussionsupporting

confidence: 67%

Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol

Cunha-Filho

Terres

Holanda

et al. 2007

J Assist Reprod Genet

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Section: Discussionsupporting

confidence: 67%

Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol

Cunha-Filho

Terres

Holanda

et al. 2007

J Assist Reprod Genet

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“…These results are not in complete agreement with the statistically lower follicular VEGF concentrations in the GnRH antagonist group but in agreement with our result. Contrary to the results of the present study and the above-mentioned studies (30,31) , Ferrari et al (2006) (32) found higher follicular VEGF concentrations with GnRH antagonists than with GnRH agonists. This opposite finding might be explained by the fact that in the study by Ferrari et al the indications for IVF were various (tubal factor, unexplained infertility and endometriosis), whereas in this study the indications were PCOS and male factor infertility.…”

contrasting

confidence: 99%

“…Cunha-Filho et al, 2005 (30) and Asimakopoulos et al, 2006 (31) investigated the role of GnRH antagonists on VEGF production during minimally stimulated IVF cycles with monofollicular developments compared with the natural-cycle IVF. According to their results, follicular VEGF concentrations were also lower using GnRH antagonists, but the difference was not statistically significant.…”

mentioning

confidence: 99%

The Effect of Different Ovarian Stimulation Protocols on Vascular Endothelial Growth Factor (Vegf) Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

Aboudy¹,

RedaAlKawaz²,

Ani³

2017

IJAR

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Objective:To measure the concentration of vascular endothelial growth factor (VEGF) in serum and follicular fluid of patients with PCOS at day of ova pick up after using of different IVF/ICSI protocols and to assess the pregnancy outcome. Study design: A total of 90 infertile women (55 women with Polycystic ovary syndrome and the other 35 women as a control (non PCOS) undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility Diagnosis and Assisted Reproductive Technology / AL-Nahrian University and Kamal ALSamarai Hospital, center of fertility and IVF (Baghdad/Iraq) during the period from December 2015 to the end of April 2017.The fifty five PCOS women were divided into three groups: twenty five (25) infertile women have had PCOS undergoing long Agonist protocol for ICSI cycle, fifteen (15) infertile women have had PCOS undergoing Antagonist protocol for ICSI and fifteen (15) infertile women have had PCOS undergoing short Agonist protocol for ICSI. The controlled group included 35 women were free of signs and symptoms of PCOS with regular cycles and no endocrine abnormalities undergoing ICSI cycle (15 infertile women underwent long agonist protocol, 10 women underwent short agonist and 10 women underwent antagonist protocol). In all patients, serum and follicular fluid VEGF levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay.

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“…So far, reports show there are no differences between GnRH agonist and antagonist protocols in the FF levels of AMH and inhibin B [54], estradiol (E 2 ) and progesterone (P 4 ) [54, 55], IGF-1 and EGF [55] and vascular endothelial growth factor (VEGF) and cytokines [56,57]. However, differences were reported in the levels of IGF-2 and IGF-BP4 [58].…”

Section: Hormonal Stimulationmentioning

confidence: 99%

“…However, it has long been established that ovarian gonadotrophin stimulation results in deleterious reproductive effects such as decreased fertilization and embryonic rates A GnRH antagonist or agonist, or both, is part of the COH protocol. So far, reports show there are no differences between GnRH agonist and antagonist protocols in the FF levels of AMH and inhibin B [54], estradiol (E 2 ) and progesterone (P 4 ) [54, 55], IGF-1 and EGF [55] and vascular endothelial growth factor (VEGF) and cytokines [56,57]. However, differences were reported in the levels of IGF-2 and IGF-BP4 [58].…”

Section: Hormonal Stimulationmentioning

confidence: 99%

Factors Influencing the Biochemical Markers for Predicting Mammalian Oocyte Quality

Ola

Sun

2012

Journal of Reproduction and Development

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Abstract. The need for accurate selection of the best oocytes for in vitro fertilization protocols and thus, production of embryos has driven the search for oocyte quality markers from morphological criteria to biochemical parameters. Current studies are focused on the biochemical constituents of the follicular fluid and gene expression profiling of the cumulus cells. These parameters are, however, affected by factors that must be considered before making a judgment of the oocyte's quality. These includes factors such as the type of hormonal stimulation protocol, age of oocyte donor and heat stress on the donor, all of which have been reported to influence the concentrations of many hormones, apolipoproteins, metabolites, fatty acids and growth factors in the follicular fluid and the expression of several genes in the cumulus cells. Another important point to note is species variation in the response to these extraneous influences, which thus calls for species targeted investigations. As reports are still scanty and investigations assumed to be very keen, we employed this review paper to bring attention of researchers and clinicians to those factors that may come to bear on the outcome of their investigations on oocyte and embryo quality. Key words: Cumulus cells, Follicular fluid, Mammalian oocytes, Quality prediction (J. Reprod. Dev. 58: [385][386][387][388][389][390][391][392] 2012) I t is well known that only part of the in vivo ovulated oocytes and in vitro matured oocytes are capable of developing to viable embryos after fertilization. This led to the search for a reliable indicator of oocyte quality. Thus, one of the important puzzles for reproductive biologists today is the search for a reliable noninvasive marker of the quality of oocytes for both human and animal assisted reproduction.Initial attempts at evaluating the quality of oocytes meant for in vitro fertilization (IVF) focused on the physical/morphological characteristics of the Cumulus-oocyte-complexes (COCs) [1,2]. These criteria are both noninvasive and rapid and are still generally in use today. However, recent reports on the inadequacies of a simple morphological appearance as a measure of quality suggest that morphological markers cannot be completely relied upon [3,4]. This has led to intensification of the search for alternative or complementary criteria with focus on the follicular fluid (FF) and the cumulus cells (CCs) around the oocyte.The preovulatory oocyte communicates intimately and directly with the surrounding cumulus granulosa cells through specialized transzonal cytoplasmic projections [5] and with the more distant mural granulosa cells through the follicular fluid [6]. Many biochemical substances found in these close associates of the oocyte have been studied and correlated with the developmental competence of the oocyte. Very recent attempts are even looking beyond a single substance to the totality of the biochemical constituents of the follicular fluid. This area of research is referred to as metabolomics [7]. Revelli e...

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Vascular endothelial growth factor and inhibin A in follicular fluid of infertile patients who underwent in vitro fertilization with a gonadotropin-releasing hormone antagonist

Cited by 17 publications

References 28 publications

Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol

Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol

The Effect of Different Ovarian Stimulation Protocols on Vascular Endothelial Growth Factor (Vegf) Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

Factors Influencing the Biochemical Markers for Predicting Mammalian Oocyte Quality

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