Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions

Momi, Hiroaki; Matsuyama, Wataru; Inoue, Koji; Kawabata, Masaharu; Arimura, Kimiyoshi; Fukunaga, Hideaki; Osame, Mitsuhiro

doi:10.1053/rmed.2002.1364

Cited by 44 publications

(32 citation statements)

References 15 publications

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“…Similar findings are known from pro-inflammatory cytokines, which correlate with VEGF, especially in TB pleurisy [10,23]. The current finding that the mean VEGF level in exudates was significantly higher than mean VEGF level in serum indicates local VEGF accumulation within the pleural cavity, as described in a previous study [24].…”

Section: Vegf In Pleural Effusions U Sack Et Alsupporting

confidence: 90%

Vascular endothelial growth factor in pleural effusions of different origin

Sack

Hoffmann²,

Zhao³

et al. 2005

Eur Respir J

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This study aimed to determine the diagnostic relevance of vascular endothelial growth factor (VEGF) in the pleural fluid and serum of patients with pleural effusions of different aetiology.VEGF was quantified in the pleural effusion fluid and serum of 96 patients with malignancies (58 lung cancers (CA) and 38 tumours with secondaries to the lung (TM)), 45 with congestive heart failure (CHF), 28 with tuberculosis (TB), 45 with acute infections (INF), and in the serum of 20 healthy controls.VEGF pleural effusion concentrations were significantly different in the main diagnostic groups. VEGF was higher in effusions of patients with malignancies (CA as well as TM) in comparison with INF, TB or CHF. In serum, however, high VEGF concentrations indicated CA, TM or INF, but not TB or CHF. Despite significant differences of VEGF levels in different patient groups, receiver-operating characteristic analysis revealed insufficient diagnostic value of VEGF for differential diagnosis of pleural effusions.In conclusion, vascular endothelial growth factor serum concentration is highly suggestive of the presence of lung disease in general, except for tuberculosis. In effusion fluid, the presence of vascular endothelial growth factor clearly indicates inflammatory or malignant origin. However, for diagnostic use, additional parameters besides vascular endothelial growth factor are mandatory.

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Section: Vegf In Pleural Effusions U Sack Et Alsupporting

confidence: 90%

Vascular endothelial growth factor in pleural effusions of different origin

Sack

Hoffmann²,

Zhao³

et al. 2005

Eur Respir J

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“…VEGF is an angiogenesis and inflammatory mediator, which has been associated with TB infection activity,[13,20] and levels decline after successful TB treatment [21]. In our study, we found that VEGF levels in BALF from patients with TPE without pulmonary tuberculosis were 31-fold higher than that in the controls.…”

Section: Discussionsupporting

confidence: 50%

“…VEGF is a potent multifunctional cytokine that contributes to angiogenesis and inflammation. TNF-α, VEGF, and IFN-γ levels are increased at pleural effusions in patients with TPE, suggesting a role for these cytokines in the immune response to mycobacterium infection [12,13]. …”

Section: Introductionmentioning

confidence: 99%

Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis

2012

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BackgroundTuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients without pulmonary tuberculosis.MethodsPatients with any evidence of pulmonary tuberculosis, either from radiologic or bacteriologic evaluation, were excluded. Bronchoalveolar lavage fluid (BALF) was collected from 10 newly diagnosed, untreated, HIV-negative TPE patients and 10 healthy controls. We analyzed T-lymphocyte subpopulations and measured 10 cytokines in BALF. Cytokine levels in BALF were standardised using urea.ResultsThe concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and the CD4+/CD8+ ratio of T-lymphocytes were significantly higher in TPE patients without pulmonary tuberculosis than in the controls. Of the cytokines measured in BALF, VEGF showed the highest concentration. No difference was observed in T-helper type 2 cytokines between the 2 groups.ConclusionThere were significant immune responses and increases in IFN-γ, TNF-α, and VEGF in the lung parenchyma of TPE patients without pulmonary tuberculosis. This result suggests that TPE may induce a significant immune response in lung parenchyma.

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“…Combination with other markers may be a reliable way to improve the diagnostic accuracy. Momi et al [33] found that combined sensitivity and specificity of TNF-α plus VEGF is better than testing TNF-α alone, with a higher sensitivity of 88.9%. Wong et al [35] reported that the combination of TNF-α with IFN-γ gained a high-diagnostic performance.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy

Li¹,

Luo²,

Zhu

et al. 2016

Medicine

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Background:The diagnosis of tuberculous pleurisy is difficult and traditional methods are not always helpful. Many studies have focused on the tumor necrosis factor-alpha (TNF-α) assay in pleural effusion for the diagnosis of tuberculous pleurisy, but the results remain controversial. This meta-analysis was conducted to determine the overall diagnostic accuracy of TNF-α.Methods:Relevant studies were searched from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wangfang, and Weipu. We pooled the published results and computed the accuracy measures, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Receiver operating characteristic curves (SROC) and the area under the curve (AUC) were used to summarize the overall test performance.Results:Twelve studies with 1022 patients met the inclusion criteria. The pooled sensitivity and specificity were 0.85 (95%CI, 0.81–0.89) and 0.80 (95% CI, 0.77–0.83) respectively. The area under the SROC curve was 0.89.Conclusions:The results of meta-analysis suggested that the TNF-α assay plays a vital role in the diagnosis of tuberculous pleurisy, whereas other test results or clinical findings should be interpreted together with the TNF-α assay to improve the overall diagnostic accuracy.

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Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions

Cited by 44 publications

References 15 publications

Vascular endothelial growth factor in pleural effusions of different origin

Vascular endothelial growth factor in pleural effusions of different origin

Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis

Diagnostic accuracy of tumor necrosis factor-alpha assay for tuberculous pleurisy

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