Vascular endothelial growth factor and apelin in plasma of patients with retinopathy of prematurity

Feng, Jing; Zhou, Ying; Zhang, Xiaorui; Jiang, Yanrong

doi:10.1111/aos.13297

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…These two studies were also single-center studies with small-sample sizes; therefore, further research is needed. Feng et al [3], also from our institution, reported results that are opposite to ours. They found that the VEGF levels in the ROP group were lower than those in the control group, while the apelin-13 levels were higher in the ROP group than in the control group.…”

Section: Discussioncontrasting

confidence: 86%

“…Several clinical studies have analyzed the relationship between ROP and systemic VEGF concentrations; however, the reported findings have been inconsistent. Some studies have shown that the level of VEGF in venous blood is not related to the occurrence of ROP; whereas, others have reported contradictory findings that preterm infants with ROP have lower blood VEGF levels [3] and that circulatory concentrations of VEGF were elevated in infants with ROP [4].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

et al. 2022

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Background Although several clinical studies have analysed the relationship between the levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood and retinopathy of prematurity (ROP), no definitive conclusions have been reached. This study aimed to investigate the relationship between apelin-13 levels and VEGF levels and ROP. Methods Differences in plasma apelin-13 and VEGF levels were analysed in two groups of infants born with birth weight < 1500 g and gestational age < 32 weeks at Peking University People’ s Hospital. One group comprised infants diagnosed with ROP and the other group was a control group comprising infants without ROP. Results Apelin-13 levels were significantly lower in the ROP group than in the control group, while VEGF levels showed the opposite result (both P < 0.001). Infants with severe ROP had lower apelin-13 levels and higher VEGF levels than with mild ROP (both P < 0.05).The receiver operating characteristic curve for apelin-13 level as the indicator of ROP showed that a cut-off value of 119.6 pg/mL yielded a sensitivity of 84.8% and a specificity of 63.6%, while for VEGF level, the cut-off value of 84.3 pg/mL exhibited a sensitivity of 84.8% and a specificity of 66.7%. Conclusions Plasma apelin-13 and VEGF levels at 4–6 weeks of age may play a role in assisting the diagnosis of ROP.

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Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

et al. 2022

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“…With the rapid development of perinatal medicine and continuous improvements in treatment facilities, the survival rate for premature and low-birth weight infants has substantially improved, and the incidence of ROP has also significantly increased in China. Many studies have suggested that the up-regulated expression of VEGF plays an important role in the development of ROP [ 39 ], and anti-VEGF drugs can inhibit the over-expression of VEGF and thereby control intraocular angiogenesis and provide a good drug treatment for ROP [ 7 , 40 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anti-VEGF drugs may reduce complications when treating ROP. At the same time, anti-VEGF drugs can maintain the balance of VEGF and promote the continued development of retinal blood vessels in children with ROP [ 7 , 40 – 42 ]. Many studies are currently ongoing to evaluate the use of anti-VEGF drugs in children with ROP [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units

et al. 2018

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BackgroundRetinopathy of prematurity (ROP) is a vascular proliferative disorder of the developing retina and a significant cause of childhood blindness around the world. The incidence of ROP is affected by many factors, and the incidence rate varies from country to country. The purpose of this study is to report the incidence and risk factors of ROP in neonatal intensive care unit (NICU) of Guangzhou First People’s Hospital in China.MethodsA retrospective review was performed on 436 premature infants who were consecutive ROP screened in the NICU of Guangzhou First People’s Hospital from March 2013 to October 2017. The single-factor analysis and the logistic multivariate regression analysis were used to detect risk factors of ROP.ResultsTotal 436 premature infants were consecutive ROP screened, 138 (31.65%) were found ROP, and 61(13.99%) were treated. The single-factor analysis revealed that the incidence of ROP was associated with multiple births, gestational age, birth weight, mechanical ventilation, intravascular hemolysis, the number of operations and blood culture results. The logistic multivariate regression analysis revealed that gestational age; birth weight, mechanical ventilation, minimum SaO2 and daily weight gain were independent risk factors for ROP onset. Forty-nine patients underwent retinal laser photocoagulation with recurrence 20 patients. Twelve patients underwent anti-VEGF drug (Ranibizumab) via intraocular injection with 5 patients of recurrence.ConclusionsThe incidence of ROP in NICU of Guangzhou China will match those in middle-income countries, but higher than high-income countries. Anti-VEGF drugs could be preferred as a good treatment method for zone 1 ROP and aggressive posterior ROP.

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“… 9 In our previous study, we examined the expression of apelin and APJ in clinical samples from infants. 10 We also reported that apelin and APJ express in the fibrovascular membranes of infants with ROP; meanwhile, anti-VEGF treatment cannot inhibit apelin expression and cannot completely suppress retinal neovascularization, which infers that apelin may play an important role in neovascularization and cannot be replaced by VEGF. 11 Moreover, apelin siRNA suppressed the proliferation of endothelial cells, which was independent of the VEGF/VEGF receptor 2 signaling pathway.…”

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confidence: 80%

The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy

Feng

Chen

Jiang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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The aim of this study was to investigate apelin and its potential neovascularization role in retinopathy of prematurity (ROP) along with the inhibitory effects of its antagonist. METHODS. We used an oxygen-induced retinopathy (OIR) mouse model to explore the progress of ROP. Apelin and angiotensin receptor-like 1 APJ expressions were examined in the retina using immunohistochemistry, quantitative polymerase chain reaction, and Western blot analysis. Additionally, the retina was examined by whole-mount staining to evaluate the retinal vessel area, vessel density, capillary width, and the number and length of tip cells. The expression of the phosphorylated mTOR (p-mTOR), p-PI3K/Akt, and pErk signaling pathway was also evaluated using Western blot analysis. RESULTS. Apelin promoted the development of superficial and deep retinal blood vessels, especially for tip cells during the physical development of retinal vessels. Additionally, apelin stimulated the density of the peripheral retinal zone vessels in OIR mice. The apelin and APJ expression levels significantly increased for the OIR model during their hypoxic phase. Next, we found that apelin mRNA levels in the OIR mice peaked at six hours after return to ambient conditions at P12, whereas the APJ mRNA levels peaked later at P17. Furthermore, the expression of p-mTOR, p-Akt, and pErk were all upregulated in OIR mice whereas F13A suppressed them instead. CONCLUSIONS. Our results suggest that apelin/APJ signaling pathway is a key factor for hypoxia-induced pathologic angiogenesis, which is a very promising new target for the treatment of ROP.

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Vascular endothelial growth factor and apelin in plasma of patients with retinopathy of prematurity

Cited by 10 publications

References 4 publications

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case–control study

The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units

The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy

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