Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner

Poimenidi, Evangelia; Theodoropoulou, Christina; Κουτσιούμπα, Μαρίνα; Skondra, Lamprini; Droggiti, Eirini; Broek, Marloes van den; Koolwijk, Pieter; Papadimitriou, Evangelia

doi:10.1016/j.vph.2016.02.008

Cited by 13 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter was further supported by data showing that VEGFA competes with PTN for binding to PTPRZ1 (Koutsioumpa et al, 2015). Binding of VEGFA to PTPRZ1 inhibits endogenous PTN levels (Poimenidi et al, 2016) that limit the angiogenic effects of VEGFA, thus enhancing VEGA-induced endothelial cell migration (Koutsioumpa et al, 2015;Poimenidi et al, 2016). More recently, we have shown that PTN selectively binds VEGFR2 and inhibits its activation by VEGFA, highlighting another mechanism through which PTN limits the angiogenic effect of VEGFA (Lamprou et al, 2020).…”

Section: Ptn and Angiogenesismentioning

confidence: 80%

On the role of pleiotrophin and its receptors in development and angiogenesis

Papadimitriou¹,

Mourkogianni²,

Ntenekou³

et al. 2022

Int. J. Dev. Biol.

Self Cite

View full text Add to dashboard Cite

The secreted growth factor pleiotrophin (PTN) is expressed in all species and is evolutionary highly conserved, suggesting that it is significant for the regulation of important processes. The observation that it is highly expressed at early stages during development and at embryonic progenitor cells, highlights a potential important contribution to development. There is ample evidence for the role of PTN in the development of the nervous system and hematopoiesis, some but still not conclusive evidence for its role in the skeletomuscular system and limited evidence for its role in the development of other organs. Studies on its role in the cardiovascular system and angiogenesis suggest that PTN has a significant regulatory effect by acting on endothelial cells, while its role in smooth or cardiac muscle cells’ functions has not been studied. This review highlights what is known up to date on the role of PTN in the development of various organs and in angiogenesis. Wherever known, evidence on the crosstalk among the receptors that mediate PTN’s functions is also quoted, highlighting the complex regulatory pathways that affect development and angiogenesis.

show abstract

Section: Ptn and Angiogenesismentioning

confidence: 80%

On the role of pleiotrophin and its receptors in development and angiogenesis

Papadimitriou¹,

Mourkogianni²,

Ntenekou³

et al. 2022

Int. J. Dev. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…This results in the release of VEGF and HGF by fibroblasts and it has been reported that enhanced synthesis of type I collagen and hyaluronic acid (HA) can be accomplished in these experimental conditions [ 125 ]. In addition, recently it has been shown that VEGFR are involved in cell migration [ 101 , 126 ]. PDGF signaling and its receptor is involved in hair follicle morphogenesis [ 127 ].…”

Section: Signaling Pathways Of Cellular Interactions Within Skinmentioning

confidence: 99%

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

Gaur

Dobke

Lunyak

2017

IJMS

156

124

View full text Add to dashboard Cite

Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.

show abstract

“…Of the nonimmune-affiliated cytokines, MK and PTN are positively regulated by epidermal growth factor (EGF) [75,77] and FGF-10 [77]. PTN is also up-regulated by FGF2 or basic FGF [78] and platelet-derived growth factor [79,80] and is downregulated by VEGF-A [81].…”

Section: Regulation Of Mk/ptn Expressionmentioning

confidence: 99%

“…The effect of the MK/PTN family on angiogenesis is thought to be through the promotion of endothelial cell proliferation and tube formation [10]. However, there are conflicting reports about the angiogenic capacity of MK/PTN on primary endothelial cells in vitro, particularly in the context of how MK/PTN affect the principal angiogenic growth factor VEGF-A [10,62,81,118]. Concomitant with the absence of vascular anomalies in PTN-null embryos [7], this suggests that the mechanisms behind PTN-mediated tumor angiogenesis may, in part, be due to its effects on other cell types in the tumor microenvironment.…”

Section: Mk/ptn Inflammation and Cancer: Sculpting The Phenotype Of Myeloid Cellsmentioning

confidence: 99%

From top to bottom: midkine and pleiotrophin as emerging players in immune regulation

Sorrelle

Dominguez

Brekken

2017

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.

show abstract

Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner

Cited by 13 publications

References 30 publications

On the role of pleiotrophin and its receptors in development and angiogenesis

On the role of pleiotrophin and its receptors in development and angiogenesis

Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

From top to bottom: midkine and pleiotrophin as emerging players in immune regulation

Contact Info

Product

Resources

About