Vascular endothelial growth factor +936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population

Abstract

The VEGF +936 T allele is associated with an increased risk of stage III-IV endometriosis in a Japanese population.

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

“…Bhanoori et al (44) demonstrated that the -460T/+405C haplotype of VEGF was less frequently identified in females with endometriosis compared to the controls, and VEGF -460 T/T homozygotes and the T allele are associated with a higher risk of endometriosis in Chinese females. There are also studies that demonstrate the association of the VEGF +936 C/T polymorphism in Caucasian and Japanese females with endometriosis (45,46). In addition, several meta-analyses have demonstrated that the VEGF +936 C/T SNP can predispose to endometriosis (47)(48)(49).…”

The association between vascular endothelial growth factor (VEGF) +405G>C genetic polymorphism and endometriosis

“…[3][4][5][6][7][9][10][11][12][13][14] The general characteristics of included eligible studies in the meta-analysis are presented in Table 1. Among the enrolled literatures, there were three studies of Asians decent 3,5,9 and eight studies of Caucasians decent.…”

“…[3][4][5][6][7][9][10][11][12][13][14] The general characteristics of included eligible studies in the meta-analysis are presented in Table 1. Among the enrolled literatures, there were three studies of Asians decent 3,5,9 and eight studies of Caucasians decent. 4,6,7,[10][11][12][13][14] These subjects were carried out in Korean, Japanese, Indian, Spanish, Turkish, Austrians, Italians, and Iranians.…”

“…In recent years, several published articles indicated that the vascular endothelial growth factor (VEGF) is one of the most important candidate genes for the development of endometriosis, and genetic polymorphisms in VEGF gene might be potentially associated with the risk of endometriosis. [3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20] The þ405G>C genetic polymorphism in 5 0 -untranslated region of VEGF gene (rs2010963), one of the most studied genetic variants resulting from G to C mutations, has been reported to affect on the regulation of VEGF gene expression and contributed to the risk of endometriosis in diverse populations. [3][4][5][6][7][9][10][11][12][13][14][15][16][17] However, findings from these published articles were conflicting but not conclusive.…”

VEGF 936C>T is predictive of threshold retinopathy of prematurity in Japanese infants with a 30-week gestational age or less

“…Using the public National Center for Biotechnology Information Single Nucleotide Polymorphism database and available literature, we selected six VEGF candidate polymorphisms, ie, −1498T.C (rs833061) and −1154G.A (rs1570360) in the promoter region, −634C.G (rs2010963) and −7C.T (rs25648) in the 5' UTR, and 936C.T (rs3025039) and 1612G.A (rs10434) in the 3' UTR. Each polymorphism showed a minor allele frequency of at least 0.10 in the Japanese population, 23,[32][33][34][35] and all polymorphisms were investigated in terms of their association with various types of diseases or clinical situations. 22,[36][37][38][39] The six VEGF genotypes were evaluated using TaqMan R minor groove binding probe-based polymerase chain reaction, and confirmed by direct sequencing, as described previously.…”