Vascular Dysfunction in Chronic Obstructive Pulmonary Disease

Maclay, John D.; McAllister, David; Mills, Nicholas L; Paterson, Finny; Ludlam, Christopher A.; Drost, Ellen; Newby, David E.; MacNee, William

doi:10.1164/rccm.200903-0414oc

Cited by 162 publications

(149 citation statements)

References 60 publications

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“…Specifically, a study that used the gold standard method to assess endothelial function (invasive measurement of forearm vasoreactivity to intraarterial infusion of vasodilators) did not identify an association between airflow limitation and endothelial function (30). In contrast, others have reported statistically significant associations between airflow limitation and endothelial function, although with large differences in effect size (6)(7)(8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 98%

“…Prior studies that have investigated the relationship between airflow limitation and endothelial function, however, have produced inconsistent results (6)(7)(8)(9)(10)(11)30). Specifically, a study that used the gold standard method to assess endothelial function (invasive measurement of forearm vasoreactivity to intraarterial infusion of vasodilators) did not identify an association between airflow limitation and endothelial function (30).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies excluded women (8); current smokers (9,11); those treated with statins or antihypertensive medication (6,10); and those with a history of coronary, cerebrovascular, or peripheral artery disease (30) or heart failure (8). In one study only 13% of eligible participants met inclusion criteria (6).…”

Section: Discussionmentioning

confidence: 99%

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Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis

Chandra¹,

Gupta²,

Strollo³

et al. 2016

Am J Respir Crit Care Med

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Rationale: Lower FEV 1 is associated with increased prevalence of atherosclerosis; however, causal mechanisms remain elusive.Objectives: To determine if systemic endothelial dysfunction mediates the association between reduced FEV 1 and increased atherosclerosis.Methods: Brachial artery endothelial function, pulmonary function, coronary artery calcium, and carotid plaque were assessed in 231 Pittsburgh SCCOR (Specialized Centers for Clinically Oriented Research) study participants; peripheral arterial endothelial function, pulmonary function, and coronary artery calcium were assessed in 328 HeartSCORE (Heart Strategies Concentrating on Risk Evaluation) study participants.Measurements and Main Results: Lower FEV 1 was independently associated with increased atherosclerosis in both cohorts (per 25% lower % predicted FEV 1 : odds ratio [OR], 1.76; 95% confidence interval [CI], 1.30-2.40; P , 0.001 for carotid plaque in SCCOR participants) (per 25% lower % predicted FEV 1 : OR, 1.35; 95% CI, 1.02-1.77; P = 0.03 for coronary artery calcium in HeartSCORE participants). Similarly, reduced endothelial function was independently associated with increased atherosclerosis in both cohorts (per SD lower endothelial function: OR, 1.30; 95% CI, 1.01-1.67; P = 0.04 for carotid plaque in SCCOR participants) (per SD lower endothelial function: OR, 1.38; 95% CI, 1.09-1.76; P = 0.008 and OR, 1.41; 95% CI, 1.07-1.86; P = 0.01 for coronary artery calcium in SCCOR and HeartSCORE participants, respectively). However, there was no association between endothelial dysfunction and FEV 1 , FEV 1 /FVC, low-attenuation area/visual emphysema, and diffusing capacity in SCCOR participants, and between endothelial dysfunction and FEV 1 or FEV 1 /FVC in HeartSCORE participants (all P . 0.05). Adjusting the association between FEV 1 and atherosclerosis for endothelial dysfunction had no impact.Conclusions: Endothelial dysfunction does not mediate the association between airflow limitation and atherosclerosis. Instead, airflow limitation and endothelial dysfunction seem to be unrelated and mutually independent predictors of atherosclerosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis

Chandra¹,

Gupta²,

Strollo³

et al. 2016

Am J Respir Crit Care Med

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show abstract

“…Patients with COPD present vessels with increased arterial stiffness [96]; the vessels are less elastic and correlate with disease severity [120], probably due to altered ECM structure [121]. The systemic inflammation may affect elasticity in the pulmonary vessels and C -reactive protein (CRP; high levels indicate infection or inflammation) in serum correlate positively with arterial stiffness [122].…”

Section: Vascular Changes and Growth Factors In Copdmentioning

confidence: 99%

Pulmonary vascular changes in asthma and COPD

Harkness

Kanabar

Sharma

et al. 2014

Pulmonary Pharmacology & Therapeutics

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In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

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“…Показано, що в групі пацієнтів, що переносять більше двох загострень у рік, значно зростає рівень запальних маркерів у мокротинні і крові, збільшується ризик повторних загострень, знижується якість життя, швидше від-бувається прогресування бронхіальній обструкції, достовірно збільшується смертність [1]. Еластич-ність судин розглядається, як самостійний патоге-нетичний фактор при кардіоваскулярній патології у пацієнтів з ХОЗЛ [9]. Актуальність проблеми коморбідності ГХ та ХОЗЛ, потребує більш де-тального вивчення проблеми причино наслідкових зв'язків.…”

Section: вступunclassified

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

Yatsenko¹

2017

ScienceRise: Medical Science

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Vascular Dysfunction in Chronic Obstructive Pulmonary Disease

Cited by 162 publications

References 60 publications

Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis

Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis

Pulmonary vascular changes in asthma and COPD

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

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