Vascular diseases

Calonje, Eduardo; Brenn, Thomas; Lazar, Alexander J.

doi:10.1016/b978-1-4160-5649-2.00016-0

Cited by 6 publications

(5 citation statements)

References 763 publications

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“…The reservoir is badgers, hedgehogs, rodents and cats; scratches and bites from the latter two are the the most common causes of human infection 1–3. Following an incubation period of 7–10 days, infected humans develop inflamed macules on the hands or face that progress to painful, ulcerating vesiculopustular lesions that form black deep-seated eschars 1. Cowpox is usually self-limiting and lesions heal and scar within 3–4 weeks1; this was the outcome in the current case, and the patient gave birth to a healthy baby.…”

Section: Discussionmentioning

confidence: 61%

“…Following an incubation period of 7–10 days, infected humans develop inflamed macules on the hands or face that progress to painful, ulcerating vesiculopustular lesions that form black deep-seated eschars 1. Cowpox is usually self-limiting and lesions heal and scar within 3–4 weeks1; this was the outcome in the current case, and the patient gave birth to a healthy baby. The infection may cause general malaise, fever, vomiting, sore throat, conjunctivitis, lymphangitis and persistent local lymphadenopathy.…”

Section: Discussionmentioning

confidence: 61%

“…Occasional eosinophilic intranuclear inclusions may be present but large eosinophilic homogeneous intracytoplasmic inclusions (Guarnieri bodies), in a distinctly crowded array within the follicles, are paradigmatic of cowpox infection 1. Immunohistochemistry was negative for Herpes simplex virus (HSV)-1, HSV-2 and varicella zoster virus.…”

Section: Discussionmentioning

confidence: 99%

“…Cowpox virus is a double-stranded DNA virus of the Orthopoxvirus genus 1. The reservoir is badgers, hedgehogs, rodents and cats; scratches and bites from the latter two are the the most common causes of human infection 1–3.…”

Section: Discussionmentioning

confidence: 99%

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Rare necrotic lesion in a pregnant woman

Wiggins¹,

Hayes²,

Heymann³

et al. 2018

J Clin Pathol

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Rare necrotic lesion in a pregnant woman

Wiggins¹,

Hayes²,

Heymann³

et al. 2018

J Clin Pathol

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“…In early stages, cytotoxic T lymphocytes attack the hair bulb, eventually leading to hair loss. In later stages, inflammation decreases and follicle atrophy increases 21,32,37 . AIGA and AA are both mediated by inflammatory cells, have an interferon‐driven inflammatory response, and a postinflammatory atrophic phase.…”

Section: Discussionmentioning

confidence: 99%

Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis

Sano¹,

Asahina

Araki

et al. 2023

Acad Dermatol Venereol

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BackgroundAcquired idiopathic generalized anhidrosis (AIGA) leads to heat intolerance due to the loss or reduction in thermoregulatory sweating over an extensive area of the body. The pathomechanism of AIGA is still unclear but is believed to be autoimmune.ObjectivesWe investigated the clinical and pathological features of inflammatory AIGA (InfAIGA) and noninflammatory AIGA (non‐InfAIGA) within the skin.MethodsWe compared anhidrotic and normohidrotic skin samples from 30 patients with InfAIGA and non‐InfAIGA, as well as skin samples of melanocytic nevus as a negative control. We conducted morphometric analysis and immunohistochemical analysis of cell types and expression of inflammatory molecules (TIA1, CXCR3 and MxA). MxA expression was used as a proxy for type 1 interferon activity.ResultsWe found that tissue samples from patients with InfAIGA exhibited inflammation within the sweat duct and atrophy of the sweat coil, whereas patients with non‐InfAIGA exhibited only atrophy of the sweat coil. Cytotoxic T lymphocyte infiltration and MxA expression were only observed in the sweat ducts of patients with InfAIGA.ConclusionsInfAIGA is associated with increased sweat duct inflammation and sweat coil atrophy, whereas non‐InfAIGA is only associated with sweat coil atrophy. These data suggest that inflammation leads to epithelial destruction of sweat ducts associated with the sweat coil atrophy and subsequent loss of function. Non‐InfAIGA may be regarded as a postinflammatory state of InfAIGA. These observations indicate the contribution of both type 1 and type 2 interferons to sweat gland injury. The mechanism involved is similar to the pathomechanism of alopecia areata (AA).

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Testicular lymphocytic vasculitis treated with prednisolone and azathioprine

Kanzawa

Imai

Mizuno

et al. 2015

Modern Rheumatology

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Testicular vasculitis is a rare condition and little is known about its morphological features. Herein, we report a case of testicular lymphocytic vasculitis, which is rarely documented, in an elderly man. He presented with left testicular swelling and fever, but without any signs of other organ involvement. He was effectively treated with prednisolone and azathioprine. This case report offers information related to the disease course and the importance of biopsy.

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Vascular diseases

Cited by 6 publications

References 763 publications

Rare necrotic lesion in a pregnant woman

Rare necrotic lesion in a pregnant woman

Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis

Testicular lymphocytic vasculitis treated with prednisolone and azathioprine

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