Vascular development in the mouse embryonic pancreas and lung

Colen, Kari L.; Crisera, Christopher A.; Rose, Michael I.; Connelly, Patrick R.; Longaker, Michael T.; Gittes, George K.

doi:10.1016/s0022-3468(99)90373-1

Cited by 34 publications

(20 citation statements)

References 20 publications

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“…In mice, Ang 1 is produced by lung mesenchyme and smooth muscle, whereas Tie-2 expression is restricted to endothelium (545,553). The expression of Ang 1 and Tie-2 in mouse lung is measureable early on (E9.5) and increases throughout gestation (116,236), although the spatial expression was not determined in these studies.…”

Section: Factors Regulating Vascular Development Growth Factorsmentioning

confidence: 85%

Lung Circulation

Suresh

Shimoda

2016

Comprehensive Physiology

104

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The circulation of the lung is unique both in volume and function. For example, it is the only organ with two circulations: the pulmonary circulation, the main function of which is gas exchange, and the bronchial circulation, a systemic vascular supply that provides oxygenated blood to the walls of the conducting airways, pulmonary arteries and veins. The pulmonary circulation accommodates the entire cardiac output, maintaining high blood flow at low intravascular arterial pressure. As compared with the systemic circulation, pulmonary arteries have thinner walls with much less vascular smooth muscle and a relative lack of basal tone. Factors controlling pulmonary blood flow include vascular structure, gravity, mechanical effects of breathing, and the influence of neural and humoral factors. Pulmonary vascular tone is also altered by hypoxia, which causes pulmonary vasoconstriction. If the hypoxic stimulus persists for a prolonged period, contraction is accompanied by remodeling of the vasculature, resulting in pulmonary hypertension. In addition, genetic and environmental factors can also confer susceptibility to development of pulmonary hypertension. Under normal conditions, the endothelium forms a tight barrier, actively regulating interstitial fluid homeostasis. Infection and inflammation compromise normal barrier homeostasis, resulting in increased permeability and edema formation. This article focuses on reviewing the basics of the lung circulation (pulmonary and bronchial), normal development and transition at birth and vasoregulation. Mechanisms contributing to pathological conditions in the pulmonary circulation, in particular when barrier function is disrupted and during development of pulmonary hypertension, will also be discussed.

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Section: Factors Regulating Vascular Development Growth Factorsmentioning

confidence: 85%

Lung Circulation

Suresh

Shimoda

2016

Comprehensive Physiology

104

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“…In the developing lung VEGF-R1 and -R2 (Breier et al, 1995), Tie-1 (Partanen et al, 1996) and Tie-2 (Sato et al, 1995) are expressed within the mesenchyme by endothelial cells and their presumptive precursors. In addition, the Tie-2 ligands Ang-1 and Ang-2 have been detected in developing lung as early as E9.5 (Colin, 1999). The general function and developmental role of these receptors and ligands have been deduced from studies of transgenic knockout mice.…”

Section: Discussionmentioning

confidence: 99%

Embryonic vasculogenesis by endothelial precursor cells derived from lung mesenchyme

et al. 2000

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“…Their role in embryonic development in general (Maisonpierre et al, 1997;Suri et al, 1996Suri et al, , 1998 or in the organogenesis of various organs such as the heart (Tomanek and Zheng, 2002), kidneys (Woolf and Yuan, 2001), lungs, and pancreas (Colen et al, 1999) has been described.…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional reconstruction of the remodeling of the systemic vasculature in early pig embryos

Cornillie

Broeck

Simoens

2007

Microscopy Res & Technique

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Current research on angiogenesis and vascular regression is mainly focused on pathological conditions such as tumor growth and diabetic retinopathy, while a suitable physiological model to study the controlling factors in these processes is still lacking. The remodeling pattern of the embryonic vasculature into the adult configuration, such as the branchial arch arterial system developing into the aorta or the early embryonic veins building the caudal vena cava can potentially serve as a model. However, practical applications of the embryonic vascular patterning are impeded by the current controversy over the exact development of the caudal vena cava in mammals. To elucidate these ambiguities, specific developmental stages of vascular development in pig embryos were mapped by means of computer-assisted 3D reconstructions starting from histological serial sections of Bouin's fixed embryos. Special attention was given to venous segments in the lumbar region, as their origin and fate are equivocally described in literature. Here we demonstrate that these venous segments originate from the caudal cardinal veins which are forced to migrate during development into a more dorsal position due to the expansion of the developing metanephroi and the more dorsal relocation of the umbilical arteries. These findings are in contrast with the generally accepted theory that the venous segments in the lumbar region arise from newly formed veins that are located dorsal to the early caudal cardinal system.

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Vascular development in the mouse embryonic pancreas and lung

Cited by 34 publications

References 20 publications

Lung Circulation

Lung Circulation

Embryonic vasculogenesis by endothelial precursor cells derived from lung mesenchyme

Three‐dimensional reconstruction of the remodeling of the systemic vasculature in early pig embryos

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