Vascular Density Does Not Predict Future Metastatic Disease in Clinical Stage 1 Non-Seminomatous Germ Cell Tumours of the Testis

Maher, TM; Lee, A.H.S.

doi:10.1016/s0022-5347(01)61843-3

Cited by 4 publications

(10 citation statements)

References 20 publications

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“…One advantage of central review is that the interpretation should be more consistent. Our interpretation of vascular invasion in stage 1 NSGCT is predictive of relapse in men treated with a policy of surveillance [ 8].…”

Section: Discussionmentioning

confidence: 99%

The value of central histopathological review of testicular tumours before treatment

Lee¹,

Mead²,

Theaker³

1999

BJU International

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Objective To assess the value of central histopathological review of testicular tumours. Materials and methods The histopathology reports of the referring hospital and central review were compared for all referred testicular specimens (201 orchidectomies and seven testicular biopsies) from 11 hospitals in one region, between 1992 and 1997. Results There were two main findings: First, there was a major discrepancy of tumour type in 12 specimens (6%). The most frequent change (in five cases) was from seminoma to nonseminomatous germ cell tumour (NSGCT). There were also difficulties with uncommon tumours such as spermatocytic seminoma, lymphoma and adenocarcinoma. Treatment was changed as result of the altered diagnosis in eight of these 12 patients. Second, there were discrepancies of interpretation of vascular invasion in 12 of 59 NSGCTs (20%). Differences of tumour elements recognized in NSGCTs were frequent. Conclusions The errors discovered on central histopathological review of testicular tumours were significant, though small in number. This supports the idea of central review and is consistent with the specialization recommended in the Calman–Hine cancer arrangements.

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Section: Discussionmentioning

confidence: 99%

The value of central histopathological review of testicular tumours before treatment

Lee¹,

Mead²,

Theaker³

1999

BJU International

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“…A total of 21 studies reported the univariable analysis of LVI [10,[15][16][17][18]21,[23][24][25][26][27]29,30,33,35,[39][40][41][42][43]47], and this was statistically significant in 18 studies [10,[15][16][17][23][24][25][26][27]30,33,35,[39][40][41][42][43]47].…”

Section: As a Risk Factor For Recurrencementioning

confidence: 99%

“…A total of 27 studies analysed the association between EC and relapse (Table 3) [10,[15][16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][33][34][35][40][41][42][43][45][46][47]. In 12 studies, EC was analysed as present vs absent.…”

Section: Ec As a Risk Factor For Recurrencementioning

confidence: 99%

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Lymphovascular invasion and presence of embryonal carcinoma as risk factors for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour: a systematic review and meta‐analysis

et al. 2020

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Objective To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour (CS I NSGCT). Materials and methods The PubMed, Embase (OVID) and SCOPUS databases were searched up to March 2019. Studies reporting on the association between LVI and/or EC and occult metastatic disease were considered for inclusion. The quality and risk of bias were evaluated by the Quality in Prognosis Studies tool. Results We screened 5287 abstracts and 207 full‐text articles. We included 35 studies in the narrative synthesis and 24 studies in a meta‐analysis. LVI showed the strongest effect. Pooled rates of occult metastasis were 47.5% and 16.9% for LVI‐positive and LVI‐negative patients, respectively (odds ratio [OR] 4.33, 95% confidence interval [CI] 3.55–5.30; P < 0.001). Pooled rates of occult metastasis were 33.2% for EC presence and 16.2% for EC absence (OR 2.49, 95% CI 1.64–3.77; P < 0.001). Pooled rates of occult metastasis were 40.0% for EC >50% and 20.0% for EC <50% (OR 2.62, 95% CI 1.93–3.56; P < 0.001). Conclusions LVI is the strongest risk factor for relapse. The prognostic value of EC is high, but there is no common agreement on how to define this risk factor. Both EC presence and EC >50% have similar ORs for occult metastasis. This shows that the assessment of EC presence is sufficient for the classification of EC.

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“…In this regard, microvascular density counts (MVD) have been extensively employed to assess the aggressiveness of malignant disease [9]. However, recent confounding reports demonstrate a perplexing lack of correlation between vascular density indices and tumor aggressiveness in a variety of cancers [10,11]. Also, metastasis in breast cancer has been reported to occur via angiogenic and nonangiogenic pathways [12], which suggests alternative mechanisms for tumor dissemination and possibly perfusion.…”

Section: Introductionmentioning

confidence: 99%

Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: Role in vasculogenic mimicry

et al. 2002

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A multidisciplinary approach to assess vasculogenic mimicry by prostatic tumor cells has revealed supportive evidence that it occurs in invasive, heterogeneous prostate cancer cell lines, and circumstantially in aggressive rat and human tumors. These results reflect the plasticity of aggressive prostatic tumor cells and may provide new prognostic markers for clinical diagnosis and new therapeutic intervention strategies.

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Vascular Density Does Not Predict Future Metastatic Disease in Clinical Stage 1 Non-Seminomatous Germ Cell Tumours of the Testis

Cited by 4 publications

References 20 publications

The value of central histopathological review of testicular tumours before treatment

The value of central histopathological review of testicular tumours before treatment

Lymphovascular invasion and presence of embryonal carcinoma as risk factors for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour: a systematic review and meta‐analysis

Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: Role in vasculogenic mimicry

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