Vascular Dementia Prevention: A Risk Factor Analysis

Román, Gustavo C.

doi:10.1159/000089361

Cited by 130 publications

(102 citation statements)

References 202 publications

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“…First, hypoperfusion of the brain has been associated with increased cerebrovascular damage (29)(30)(31), cortical atrophy (32), and risk of cognitive impairment (33). Definition of abbreviations: CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; ICU = intensive care unit; IPF = idiopathic pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium

et al. 2016

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Rationale: Delirium is common following lung transplant and is associated with poorer clinical outcomes. The extent to which intraoperative hemodynamic alterations may contribute to postoperative delirium among lung transplant recipients has not been examined. Objectives:To examine the impact of intraoperative hemodynamic changes on neurobehavioral outcomes among lung transplant recipients.Methods: Intraoperative hemodynamic function during lung transplant was assessed in a consecutive series of patients between March and November 2013. Intraoperative cerebral perfusion pressure was assessed every minute in all patients. Following lung transplant, patients were monitored for the presence and severity of delirium using the Confusion Assessment Method and the Delirium Rating Scale until hospital discharge.Measurements and Main Results: Sixty-three patients received lung transplants, of whom 23 (37%) subsequently developed delirium. Lower cerebral perfusion pressure was associated with increased risk of delirium (odds ratio [OR], 2.08 per 10-mm Hg decrease; 95% confidence interval [CI], 1.02-4.24; P = 0.043), longer duration of delirium (OR, 1.7 d longer per 10-mm Hg decrease; 95% CI, 1.1-2.7; P = 0.022), and greater delirium severity (b = 20.81; 95% CI, 21.47 to 20.15; P = 0.017).Conclusions: Poorer cerebral perfusion pressure during lung transplant is associated with greater risk for delirium following transplant, as well as greater duration and severity of delirium, independent of demographic and medical predictors. Author Contributions: Concept and design, J.A.B., S.K.R., R.D.D., S.M.P., J.P.M., and P.J.S. Data collection, P.J.S., J.P.M., B.M.H., and S.K.R. Analysis and interpretation of the data, P.J.S., J.P.M., and J.A.B. Drafting of the manuscript, P.J.S., J.P.M., S.M.P., and J.A.B. Critical revision of the article for important intellectual content, P

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Section: Discussionmentioning

confidence: 99%

Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium

et al. 2016

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“…Additionally, functional levels of MSRA in selected tissues are reported to decrease with age and are lower in patients with Alzheimer's disease [44,45]. Both of these conditions are associated with an increased risk of cardiac arrhythmia [46,47]. hERG channels are also expressed in neuronal cells where they are postulated to be involved in regulation of neuronal excitability [8].…”

Section: Discussionmentioning

confidence: 99%

Functional consequences of methionine oxidation of hERG potassium channels

Limberis

Martin

et al. 2007

Biochemical Pharmacology

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Reactive species oxidatively modify numerous proteins including ion channels. Oxidative sensitivity of ion channels is often conferred by amino acids containing sulfur atoms, such as cysteine and methionine. Functional consequences of oxidative modification of methionine in hERG1 (human ether à go-go related gene 1), which encodes cardiac I Kr channels, are unknown. Here we used chloramine-T (ChT), which preferentially oxidizes methionine, to examine the functional consequences of methionine oxidation of hERG channels stably expressed in a human embryonic kidney cell line (HEK 293) and native hERG channels in a human neuroblastoma cell line (SH-SY5Y). ChT (300 µM) significantly decreased whole-cell hERG current in both HEK 293 and SH-SY5Y cells. In HEK 293 cells, the effects of ChT on hERG current were time-and concentration-dependent, and were markedly attenuated in the presence of enzyme methionine sulfoxide reductase A that specifically repairs oxidized methionine. After treatment with ChT, the channel deactivation upon repolarization to −60 or −100 mV was significantly accelerated. The effect of ChT on channel activation kinetics was voltage-dependent; activation slowed during depolarization to +30 mV but accelerated during depolarization to 0 or −10 mV. In contrast, the reversal potential, inactivation kinetics, and voltage-dependence of steady-state inactivation remained unaltered. Our results demonstrate that the redox status of methionine is an important modulator of hERG channel.

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“…Sources: All [3], except vascular dementia [4], macular degeneration [5], low back pain [6], tuberculosis [7], diabetes [8] and smokeless tobacco [9]. Reproduced from [2] with permission from the publisher.…”

Section: Smokeless Tobacco Usementioning

confidence: 99%

“…The range of fatal and nonfatal diseases caused or exacerbated by smoking is extensive (table 1) [2][3][4][5][6][7][8][9]. The present article discusses why treatments to aid smoking cessation are a crucial element of tobacco control policy and the importance of efforts to encourage as many smokers as possible to use them.…”

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confidence: 99%

Clinical and public health significance of treatments to aid smoking cessation

West¹,

Stapleton²

2008

European Respiratory Review

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There is good epidemiological evidence to show that for every continued year of smoking over the age of 40 yrs, the average smoker loses 3 months of life expectancy.Treatments to aid smoking cessation have the potential to save tens of thousands of lives annually if they: 1) lead users of those treatments to stop significantly earlier than they would otherwise have done; 2) do not undermine quitting in nonusers; and 3) are used by a significant proportion of smokers. There is strong evidence from high-quality randomised controlled trials to show that currently available treatments improve the chances of a cessation attempt succeeding permanently by between 2.5 and 10% points. For each success this brings forward quitting by an average of 25-30 yrs. Failure of a cessation attempt at 40 yrs of age costs an estimated 6-7 yrs of life expectancy.There is no evidence that introducing and publicising treatments undermines quitting in nonusers. The major factor limiting the public health benefit of treatments to aid cessation is the numbers of smokers that use them. At present, the most effective treatment combination of behavioural support plus medication is used by a very small minority of smokers.It is estimated that for every 100,000 smokers who use proven treatments to aid cessation, between 7,500 and 30,000 life-years will be saved in the future depending on the treatment. In England (UK), the use of smoking cessation treatment in 2008 is expected to save 270,000 lifeyears. A major priority for tobacco control should be finding ways of encouraging more smokers to use the most effective treatments.

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Vascular Dementia Prevention: A Risk Factor Analysis

Cited by 130 publications

References 202 publications

Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium

Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium

Functional consequences of methionine oxidation of hERG potassium channels

Clinical and public health significance of treatments to aid smoking cessation

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