Vascular damage in obese female rats with hypoestrogenism

Lima-Mendoza, Luis Angel; Colado-Velázquez, Juventino Iii; Mailloux-Salinas, Patrick; Espinosa-Juárez, Josué Vidal; Gómez-Viquez, Norma Leticia; Molina-Muñoz, Tzindilú; Huang, Fengyang; Bravo, Gerardo Ferrando

doi:10.1007/s13105-013-0283-2

Cited by 6 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under this condition, there is an increase in food intake, body weight, and visceral adipose tissue. This, in turn, leads to other alterations, such as oxidative stress, inflammation, glucose intolerance, insulin resistance, dyslipidemia, hypertension, and hepatic and pancreatic damage, which can be exacerbated by hypercaloric food intake and aging . Accordingly, our data showed that HEOb rats exhibited a higher increase in caloric intake, body weight, adipose tissue, and oxidative stress than HE rats; indeed, Cap, Ex, and Cap + Ex treatments have higher effects in HEOb rats.…”

Section: Discussionmentioning

confidence: 55%

See 1 more Smart Citation

Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats

et al. 2020

Self Cite

View full text Add to dashboard Cite

BACKGROUND The aim of this study was to evaluate the effects of capsaicin (Cap), moderate exercise (Ex), and their combination on arterial blood pressure (BP) and metabolic complications in hypoestrogenic (HE) obese (HEOb) rats. Female Wistar rats were ovariectomized and given 300 g L−1 sucrose solution (HEOb), or purified water (HE) ad libitum, for 28 weeks. After shaving the abdominal skin, cold cream vehicle was applied to sedentary (Sed) and exercise (Ex) groups, and 0.75 g kg−1 Cap cream was applied to Ex groups. Ex groups ran on a treadmill every day for 20 min at speeds from 0.15 to 0.3 m s−1. For combination groups (Cap + Ex), topical Cap was applied 90 min before Ex. The treatments were performed for 6 weeks, and BP was recorded before and at the end of the experimental protocol. The animals were killed by decapitation, and blood and tissues were obtained to perform oxidative profile, as well as to undertake biochemical and histologic studies. RESULTS Compared with individual treatments, the combined therapy (Cap + Ex) in HEOb rats caused a higher reduction in the caloric intake, body weight, abdominal fat percentage, oxidative stress, and hepatic steatosis. In HEOb groups, Cap was the only treatment that reduced BP and prevented dyslipidemia and oxidative stress. CONCLUSION The present data show that Cap improves the metabolic alterations induced by obesity and hypoestrogenism, suggesting that Cap can be considered as an excellent candidate for therapy of these clinical conditions. © 2020 Society of Chemical Industry

show abstract

Section: Discussionmentioning

confidence: 55%

“…At 1 week after surgery, animals received a carbohydrate‐based hypercaloric diet to induce obesity, as previously reported . Briefly, during a 28 week period, HEOb rats were given 300 g L −1 refined sucrose (Ingenio Azucarero el Potrero, Veracruz, Mexico) in their drinking water ad libitum , whereas HE rats were given tap water.…”

Section: Methodsmentioning

confidence: 99%

Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The ovariectomized female rat model has been commonly used to study the underlying mechanisms of pain perception associated with obesity [Stubbins et al, 2012;Da Silva et al, 2014] where a high sucrose (30%) diet can induce obesity [Kawasaki et al, 2005;Lima-Mendoza et al, 2014]. The aim of the present study was to analyse pain sensitivity using thermal stimuli (plantar test) over a 24 week period using a high sucrose diet in ovariectomized and na€ ıve Wistar rats to clarify the behavioural response to a nociceptive stimuli at various stages of weight gain.…”

Section: Introductionmentioning

confidence: 99%

Nociceptive Alteration by High Sucrose Diet in Hypoestrogenic Wistar Rats

Jaramillo-Morales

Espinosa-Juárez

Corona-Ramos

et al. 2016

Drug Development Research

View full text Add to dashboard Cite

Preclinical Research Obesity is a risk factor associated with alterations in pain perception. The aim of this study was to analyse a time-course of nociceptive responses (plantar test) in hypoestrogenic rats after the induction of obesity. Animals (hypoestrogenic and naïve) received either a hypercaloric or regular diet for 24 weeks. Thermal nociception and body weight were measured during this period. At the 4th and 17th weeks after treatment, oral glucose tolerance, blood insulin levels, abdominal fat weight, and uric acid levels were measured. The hypoestrogenic rats on a high sucrose diet had higher body weight and abdominal fat weight than control rats. A biphasic response was observed in the ovariectomized group fed with sucrose with thermal latency being decreased in the fourth week. During weeks 12-18, thermal latency increased compared to that of the hypoestrogenic control. There were no differences in basal blood glucose levels at the 4th and 17th weeks; however, oral glucose tolerance, insulin, and uric acid levels were altered. This indicated that increased body weight and fat as well as alteration sin glucose tolerance, hyperinsulinemia and hyperuricemia, may be associated with the biphasic nociceptive response. Drug Dev Res 77 : 258-266, 2016. © 2016 Wiley Periodicals, Inc.

show abstract