Vascular control of ovarian function: ovulation, corpus luteum formation and regression

Acosta, Tomás J.; Miyamoto, Akio

doi:10.1016/j.anireprosci.2004.04.022

Cited by 147 publications

(99 citation statements)

References 62 publications

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“…However, there is little information about the role played by the neural factors in NO release in cyclic rats. Considering the increasingly recognized influence of the ovary innervation in the control of the diverse organ functions in different reproductive states (Aguado & Ojeda 1984, Sosa et al 2000, Casais et al 2001, Garraza et al 2004, and the participation of NO in steroidogenesis, as observed in prepubertal rats , and also in the biochemical and vascular changes that occur in the ovulating period, development and regression of the corpus luteum (Acosta & Miyamoto 2004), we also thought it could be interesting to study the neural influence of the superior mesenteric ganglion on the NO ovarian liberation during oestrus. The oestrus is the stage of the oestrous cycle when there is more ovarian irrigation (Acosta & Miyamoto 2004), and the nervous plexus is related with the blood flow (Lawrence & Burden 1980).…”

Section: Introductionmentioning

confidence: 99%

“…Considering the increasingly recognized influence of the ovary innervation in the control of the diverse organ functions in different reproductive states (Aguado & Ojeda 1984, Sosa et al 2000, Casais et al 2001, Garraza et al 2004, and the participation of NO in steroidogenesis, as observed in prepubertal rats , and also in the biochemical and vascular changes that occur in the ovulating period, development and regression of the corpus luteum (Acosta & Miyamoto 2004), we also thought it could be interesting to study the neural influence of the superior mesenteric ganglion on the NO ovarian liberation during oestrus. The oestrus is the stage of the oestrous cycle when there is more ovarian irrigation (Acosta & Miyamoto 2004), and the nervous plexus is related with the blood flow (Lawrence & Burden 1980). With this purpose in mind, this work intends (1) to standardize an integrated ex vivo superior mesenteric ganglion-ONP-ovary system in oestrus day rats; (2) to determine if the ganglion cholinergic stimulus modifies the release of nitric oxide and steroids in the ovary compartment in the absence of humoral factors; and (3) to investigate if there are differences in the responses between the left and right ovaries caused by the neural stimulus.…”

Section: Introductionmentioning

confidence: 99%

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The cholinergic influence on the mesenteric ganglion affects the liberation of ovarian steroids and nitric oxide in oestrus day rats: characterization of an ex vivo system

Orozco¹,

Sosa²,

Fillipa³

et al. 2006

Journal of Endocrinology

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The axons that constitute the ovarian nervous plexus originate mostly in the principal neurons of the superior mesenteric ganglion (SMG) that is part of the sympathetic ganglionic chain and exhibits cholinergic receptors. In order to observe the effect of acetylcholine, the main neurotransmitter in the ganglionic transmission, the purpose of the present work was: first, to standardize an integrated ex vivo superior mesenteric ganglion-ovarian nervous plexus-ovary (SMG-ONP-O) system in oestrus day rats; secondly, to determine if the ganglionic cholinergic stimulus modifies the release of nitric oxide and steroids in the ovary compartment in the absence of humoral factors; and thirdly, to investigate if there are differences in the responses between the left and right ovaries caused by the neural stimulus. The ex vivo experimental left and right systems were developed and standardized. The systems were incubated in Krebs-Ringer phosphate buffer in a Dubnoff metabolic shaker. The progesterone release was determined to standardize the incubation times, obtaining different responses between the left and right systems, which shows that both systems have their own autonomic tone. Non-specific stimulation with KCl in the ganglion compartment provoked different responses in terms of release of progesterone and oestradiol. Progesterone decreased in the left and right systems.However, oestradiol diminished at short times and increased at 60 and 120 min in the left ovary, whereas it increases at 30 and 60 min in the right ovary. These different responses show the sensitivity and viability of both systems. When acetylcholine was used in the ganglion compartment, the release of nitric oxide, progesterone, androstenedione and oestradiol was evaluated. The liberation of nitrite increased at 15, 30 and 60 min in the left system and decreased in the right system at 120 min. Progesterone showed a decrease in its release at 15, 30 and 120 min and androstenedione at 15 min in the left ovary compartment. In the right ovary, only progesterone decreased in relation to the control at 120 min while androstenedione did not show significant changes. Oestradiol showed an increase in the left ovary compartment at all the studied times, while in the right ovary it did not show any changes. These results indicate that the neural stimulus from the superior mesenteric ganglion through the ovarian nervous plexus is one of the factors modulating the secretory activity of the ovarian steroids and nitric oxide. The system is viable and also shows a different sensitivity of the left ovary in relation to the right one at least in this cycle stage, characterized by marked irrigation and profound structural changes in the ovary.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The cholinergic influence on the mesenteric ganglion affects the liberation of ovarian steroids and nitric oxide in oestrus day rats: characterization of an ex vivo system

Orozco¹,

Sosa²,

Fillipa³

et al. 2006

Journal of Endocrinology

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“…Measurement of CL vascularity was suggested as a diagnosis technique for early pregnancy, but the early detection of pregnancy by evaluation of CL vascularity did not appeared to be a specific and sensitive method (Utt et al 2009). The physiologic aspects of CL vascularity by ultrasonography during formation and lysis were previously described in cows (Acosta et al 2003, Acosta & Miyamoto 2004, Miyamoto et al 2005, Ginther et al 2007), using objective and subjective analyses (Ginther et al 2007). The corpus luteum vascularity is immediately constituted after ovulation (Reynolds et al 2000), and CL vascularity is associated with its functionality (Bollwein et al 2002b).…”

Section: Introductionmentioning

confidence: 99%

Follicle and corpus luteum size and vascularity as predictors of fertility at the time of artificial insemination and embryo transfer in beef cattle

et al. 2015

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Abstract:Two ultrasound based fertility prediction methods were tested prior to embryo transfer (ET) and artificial insemination (AI) in cattle. Female bovines were submitted to estrous synchronization prior to ET and AI. Animals were scanned immediately before ET and AI procedure to target follicle and corpus luteum (CL) size and vascularity. In addition, inseminated animals were also scanned eleven days after insemination to target CL size and vascularity. All data was compared with fertility by using gestational diagnosis 35 days after ovulation. Prior to ET, CL vascularity showed a positive correlation with fertility, and no pregnancy occurred in animals with less than 40% of CL vascularity. Prior to AI and also eleven days after AI, no relationship with fertility was seen in all parameters analyzed (follicle and CL size and vascularity), and contrary, cows with CL vascularity greater than 70% exhibit lower fertility. In inseminated animals, follicle size and vascularity was positive related with CL size and vascularity, as shown by the presence of greater CL size and vascularity originated from follicle with also greater size and vascularity. This is the first time that ultrasound based fertility prediction methods were tested prior to ET and AI and showed an application in ET, but not in AI programs. Further studies are needed including hormone profile evaluation to improve conclusion.

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“…Since the development of ultrasound machines with color-Doppler mode for use in human and veterinary medicine, several studies have been produced to elucidate the interactions between blood flow and function of organs (Blasco et al, 1975;Brannstorm et al, 1998;Bollwein et al, 2000;Acosta and Miyamoto, 2004;Acosta, 2007;Herzog and Bollwein, 2007;Adams et al, 2008;Viana et al, 2013). In reproduction, vascular events in the preovulatory follicle (POF) and subsequent corpus luteum (CL) formation are crucial for proper functioning of reproductive events (Bollwein et al, 2002;Acosta et al, 2003;Acosta and Miyamoto, 2004;de Tarso et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In reproduction, vascular events in the preovulatory follicle (POF) and subsequent corpus luteum (CL) formation are crucial for proper functioning of reproductive events (Bollwein et al, 2002;Acosta et al, 2003;Acosta and Miyamoto, 2004;de Tarso et al, 2015). Follicle blood flow has been shown to be predictive of the following: subsequent CL blood flow and plasma progesterone concentrations (de Tarso et al, 2015), developmental and ovulatory status of follicles (Brannstorm et al, 1998;Acosta and Miyamoto, 2004;Gastal et al, 2006;Acosta, 2007;Siddiqui et al, 2010;Gastal and Gastal, 2011), establishment of pregnancy and/or fertility (Dickey, 1997;Silva et al, 2006;Siddiqui et al, 2009a), and maturity of oocytes and success of in vitro fertilization and embryo development (Bhal et al, 1999;Coulam et al, 1999;Huey et al, 1999;Ginther et al, 2007b;Siddiqui et al, 2009b) in several species such as cattle, horses, and women.…”

Section: Introductionmentioning

confidence: 99%

Novel prospects for evaluation of follicle wall blood flow using color-Doppler ultrasonography

et al. 2016

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The goal of this study was to develop an objective method for evaluation of ovarian follicle wall blood flow in cattle. Two subjective methods were used: (I) real-time ultrasound evaluations performed by one operator in the barn and (II) video clip evaluations performed by four operators in the laboratory. The following objective methods evaluated in the laboratory were used for comparison: (I) percentage of follicle wall circumference under blood flow (WUF) and (II) pixel area of color-Doppler signals. Cows (n = 21) were submitted to a synchronization protocol, follicles ≥7 mm were measured, and blood flow was evaluated every 12 h until ovulation using color-Doppler ultrasonography. No difference (P > 0.05) was observed among laboratory operators from day 2 of training onwards. Therefore, an average score of all operators was used for comparisons among different methods. Both subjective and objective methods of evaluation showed an increase (P < 0.0001) in follicle blood flow over time. Higher (P < 0.001) correlations were obtained between WUF and subjective laboratory evaluation than between WUF and pixel area or WUF and subjective barn data. Higher (P < 0.0003) correlation coefficients were observed for WUF than for the pixel area when compared with the barn (r = 0.70 vs. r = 0.42) or laboratory (r = 0.84 vs. r = 0.62) data. Subjective evaluations at the laboratory and barn produced stronger correlations with WUF (P < 0.0008) than with pixel area (P < 0.01). In conclusion, WUF is an effective and reliable method for objective evaluation of follicle wall blood flow in cows.

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Vascular control of ovarian function: ovulation, corpus luteum formation and regression

Cited by 147 publications

References 62 publications

The cholinergic influence on the mesenteric ganglion affects the liberation of ovarian steroids and nitric oxide in oestrus day rats: characterization of an ex vivo system

The cholinergic influence on the mesenteric ganglion affects the liberation of ovarian steroids and nitric oxide in oestrus day rats: characterization of an ex vivo system

Follicle and corpus luteum size and vascularity as predictors of fertility at the time of artificial insemination and embryo transfer in beef cattle

Novel prospects for evaluation of follicle wall blood flow using color-Doppler ultrasonography

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