Vascular components of cerebrospinal fluid compensation

Abstract

Cerebrovascular parameters have a limited but significant impact on CSF infusion studies. The vascular component of ICP may be identified as a significant factor contributing to this phenomenon. During infusion studies, physiological parameters influencing vascular conditions should be maintained as stable as possible.

Functional changes in CSF volume estimated using measurement of water T2 relaxation

“…This observation might arise in the case of visual stimulation from the relative ease of relocation of CSF volume between neighboring sulci, without affecting global cerebrospinal volume reserve to produce observable effects (6,7). This is in contrast to the more widespread effects of CO 2 , with its larger potential to affect the total intracranial volume and intracranial pressure (27). Figure 5c indicates that equalization of the ER c2b ϭ 0.5 can be achieved for both types of stimulation if the change in CBV under CO 2 challenge is only 10% and the change in CBV for visual stimulation is close to 30%.…”

Critical Closing Pressure Determined with a Model of Cerebrovascular Impedance

“…28 PaCO 2 affects both CCP and arterial pressure The observed changes in CCPm and WTm during intracranial hypertension and arterial hypotension are not different from those previously described. 20,22 CCPm was found to increase with increasing ICP, while it decreased with a decrease in ABP. 22 However, in contrast to previous studies 20,22 during transition from hypocapnia/normocapnia to hypercapnia, we did not observe significant changes in CCPm and WTm.…”

“…20,22 CCPm was found to increase with increasing ICP, while it decreased with a decrease in ABP. 22 However, in contrast to previous studies 20,22 during transition from hypocapnia/normocapnia to hypercapnia, we did not observe significant changes in CCPm and WTm. This finding is counterintuitive, as hypercapnia is known to lead to vasodilatation and a decrease in both WT and CCP.…”

“…Recordings from 29 experiments of male New Zealand White rabbits (weighting from 2.7 to 3.7 kg) were performed 15,19,20 including high-resolution sampling of ABP, ICP, and basilar artery FV. The experimental protocols have been described in detail [19][20][21][22] and are briefly recapitulated here. Rabbits were produced using methods described previously.…”

“…The data have been acquired in rely 1990 by HKR (Physiologist) and MC (Brain Physicist) in the same laboratory in Cambridge, in uniform manner previously described in multiple scientific publications. 15,19,20,31 In our opinion, it was rather unlikely that manipulations might interfere with each other. After each of the manipulation was completed, there was some time given in order for all the physiological parameters to stabilize to their previous unaffected level.…”