Vascular Complications of Varicella

Driesen, Yentl; Verweij, Marjoke; Maeseneer, M. De; Dooy, Jozef De; Wojciechowski, Marek; Akker, Machiel van den

doi:10.1097/inf.0000000000000855

Cited by 5 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can involve different kind of vessels: central or peripheral, and arteries or veins of different caliber. For example, deep venous thrombosis can lead to pulmonary embolism or purpura fulminans, as well as arterial complications, such as giant cells arteritis affecting extracranial circulation or granulomatous aortitis ( 19 , 22 ). VZV can affect intracerebral arteries, producing changes in arterial caliber and contractility and leading to stroke.…”

Section: Discussionmentioning

confidence: 99%

Acute Hemichorea Can Be the Only Clinical Manifestation of Post-Varicella Vasculopathy: Two Pediatric Clinical Cases

et al. 2018

View full text Add to dashboard Cite

Acute hemichorea can occur in the context of infectious, autoimmune, metabolic, toxic, and vascular neuropathologies. Primary infection by varicella zoster virus (VZV) can result in vasculopathy with neurological manifestations, such as hemiparesis, at times accompanied by hemichorea. Isolated hemichorea, however, had not been reported. We here describe two cases of VZV-induced vasculopathy whose sole clinical manifestation was acute hemichorea. Both cases involved young boys of 3 years of age, who presented with acute hemichorea 4–6 months after initial VZV infection. All hematological, immunological, and toxicological tests were normal, except for the presence of VZV IgG. Brain structural magnetic resonance imaging (MRI) and magnetic resonance angiography revealed specific signs of vasculitis and ischemic lesions in the basal ganglia region (lentiform nucleus, thalamus, and internal capsule). Following corticosteroid and acetylsalicylic acid treatment, full symptomatic recovery was achieved within 3 weeks. Repeated MRI documented full neurostructural recovery, which was confirmed at extended follow-up for more than 1 year. These cases indicate that VZV-induced vasculopathy should be considered in the case of pediatric isolated acute hemichorea.

show abstract

Section: Discussionmentioning

confidence: 99%